Could the immune system hold clues to brain diseases?

NCT ID NCT04239079

Recruiting now Knowledge-focused Sponsor: Columbia University Source: ClinicalTrials.gov ↗

First seen Aug 04, 2026 · Last updated Aug 05, 2026 · Updated 1 time

Summary

This study looks at whether the immune system's T-cells react differently in people with Parkinson's disease or Alzheimer's disease compared to healthy older adults. Researchers will collect blood samples from 120 participants—30 with Parkinson's, 30 with Alzheimer's or mild cognitive impairment, and 60 healthy controls—to measure T-cell responses to certain antigens. The goal is to better understand how inflammation and immune responses may be involved in these neurodegenerative conditions.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If immune responses are found to differ, it could point toward new ways to understand or treat these brain diseases.
What could go wrong: This is an observational study, so it won't directly test a treatment. It may only show associations, not cause and effect.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease Cognitive Dysfunction Parkinson disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALZHEIMER DISEASE MILD COGNITIVE IMPAIRMENT PARKINSON DISEASE

Contacts and locations

Locations

Columbia University Medical Center
RECRUITING

New York, New York, 10032, United States

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