COGNITIVE IMPAIRMENT, MILD

This Phase II trial tests whether siponimod, a drug already approved for multiple sclerosis, can safely slow brain atrophy in people with mild Alzheimer's disease. Over 18 months, 105 participants will receive either the drug or a placebo. Researchers will measure brain volume ch…

This large study is testing whether taking atorvastatin (a statin) can help healthy adults aged 75 and older avoid dementia, disability, and death. Participants are randomly assigned to take either the drug or a placebo for several years. The goal is to see if this simple pill ca…

This study explores whether playing popular, easy-to-use video games can improve thinking skills, mood, and engagement in older adults with mild cognitive impairment. About 60 participants will play selected PlayStation games in small groups at day centers, two to three times per…

This pilot study explores whether a music-based dance program can improve thinking skills and physical function in adults aged 55 and older with mild cognitive impairment. The dance routines combine music, partner guidance, and spatial coordination to challenge memory and attenti…

This study tests a 16-week partner exercise program called BUDPA for people with mild dementia and their family caregivers. The program involves group workouts and at-home practice, aiming to improve thinking, mood, and the relationship between the pair. Researchers will track 23…

This study tests a portable device that plays soft sounds during deep sleep to improve memory and slow cognitive decline in older adults. Sixty participants aged 60-85 with mild memory problems will use the device at home for two 4-week periods. The goal is to see if enhancing sl…

This study tests whether daily 10-15 minute personalized reminiscence sessions delivered by a digital app can improve symptoms like apathy and depression in older adults with mild neurocognitive disorders. Eighty participants over 60 will use the app for 25 days, with a caregiver…

This study tests a 12-week program called ENACT that combines hearing exercises, memory training, and family support for people with mild cognitive impairment and hearing loss. Researchers want to see if it improves thinking, hearing, and quality of life compared to usual care. T…

This study from Stanford University is looking at how a 6-week math training program changes brain activity and thinking skills in children with math learning disabilities (dyscalculia). About 180 children aged 6-12 will do math problems on a tablet at home and get weekly one-on-…

This study looks at how common depression and mild memory problems are in people hospitalized for chronic heart failure, and whether these issues lead to worse health outcomes. About 300 adults aged 18 to 85 will answer questionnaires about their mood and thinking skills. The goa…

This early-phase study investigates how scopolamine, a drug known to affect memory, changes brain activity in people with epilepsy who are already undergoing brain monitoring for seizures. Sixty participants will receive either scopolamine or a placebo and perform memory tasks wh…