COGNITIVE IMPAIRMENT, MILD

This study is testing whether a drug called siponimod, already approved for multiple sclerosis, can slow the progression of mild Alzheimer's disease. About 105 participants will take either the drug or a placebo for one year, followed by a six-month observation period. The main g…

This study is testing a 12-week program called ENACT that combines hearing exercises with memory training. It aims to help older adults who have both mild memory problems and hearing loss. Researchers want to see if this combined approach can improve communication, thinking skill…

This large study aims to see if taking a daily cholesterol-lowering statin pill (atorvastatin) can help prevent dementia, disability, and death in healthy adults aged 75 and older. About 20,000 participants will be randomly assigned to take either the statin or a placebo (inactiv…

This study is testing whether a daily digital app that helps people reminisce about personal memories can improve symptoms like low mood, lack of motivation, and poor sleep in older adults with mild cognitive impairment or early-stage dementia. Participants will use the app for a…

This study aims to understand how common depression and memory problems are in people hospitalized for chronic heart failure, and whether these conditions lead to worse recovery outcomes. Researchers will follow 300 patients, asking them survey questions during and after their ho…

This study aims to understand how a drug called scopolamine affects brain activity during memory tasks. Researchers will work with 60 adults who have epilepsy and already have electrodes implanted in their brains for medical monitoring. Participants will complete memory games on …