COGNITIVE IMPAIRMENT, MILD

This study tests whether siponimod, a drug already used for multiple sclerosis, can safely slow brain shrinkage in people with mild Alzheimer's disease. About 105 participants will receive either the drug or a placebo for 12 months, then be monitored for 6 more months. The main g…

This study is testing whether taking atorvastatin (a statin) can prevent dementia, disability, and death in healthy adults aged 75 and older who do not have heart disease or dementia. About 20,000 participants will receive either the drug or a placebo. The goal is to see if this …

This study tests a 12-week program called ENACT that combines hearing exercises with memory training for people with mild cognitive impairment and hearing loss. Researchers want to see if this approach improves thinking, hearing, and quality of life. The program includes counseli…

This study tests whether a smartphone app that delivers personalized memory sessions can improve symptoms like low mood and lack of motivation in older adults with mild neurocognitive disorders. About 80 participants over age 60 will use the app daily for 25 days. Researchers wil…

This study looks at whether a simple, music-based dance program can help older adults with mild memory or thinking problems improve their mental focus and physical abilities. The dance combines music, rhythm, and partner cues to challenge both the brain and body at the same time.…

This study tests a simple, non-invasive device that plays soft sounds during sleep to boost deep sleep and improve memory. Sixty older adults with mild memory problems will use the device at home for four weeks. Researchers will measure memory, brain activity, and blood markers t…

This study tests a 16-week partner exercise program for people with mild dementia and their family caregivers. The goal is to improve thinking, mood, and the relationship between the pair. About 236 dyads will be recruited from community centers in Hong Kong.

This study looks at how scopolamine, a drug that can cause memory problems, changes brain activity during memory tasks. About 60 adults with epilepsy who are already having brain surgery for seizure monitoring will take part. They will receive either scopolamine or a saltwater pl…

This study looks at how common depressive symptoms and mild cognitive impairment are in adults hospitalized for chronic heart failure, and whether these issues lead to worse health outcomes. Researchers will follow 300 participants for 12 months after their hospital stay, trackin…