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Virtual reality plus exercise may sharpen aging brains

NCT ID NCT06124339

Disease control Sponsor: University of California, San Diego Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 15, 2026 · Last updated Jul 16, 2026 · Updated 1 time

Summary

This study tests whether combining virtual reality cognitive training with physical activity can improve memory and brain health in adults aged 50 to 85. Participants are randomly assigned to 16 weeks of physical activity, VR cognitive activity, or both. The main goal is to see if the combined approach improves performance on a memory task that relies on the hippocampus, a brain region key for memory.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
a combination of physical activity (stationary biking) and virtual reality cognitive training
What this could lead to
If successful, this approach could offer a non-drug way to boost memory and slow age-related cognitive decline in older adults.
What could go wrong
This is a small, early-stage trial with 150 participants, so results may not apply to everyone. The interventions require regular attendance and may not be feasible for all older adults.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 150 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2023

Expected to finish

Feb 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

50 to 85 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. 50-85 years of age 2. Fluent in English 3. Can safely ride a stationary bike Exclusion Criteria: 1. Dementia 2. History of a neurological disorder 3. Severe sensory deficits 4. Inability to perform intervention (e.g., inability to cycle safely) 5. Contraindications to MRI scan (e.g., pacemaker) 6. Fear of needles/ blood 7. Prior history of fainting due to sight of needles of blood

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Conditions

The condition(s) this trial relates to.

cognitive disorder Cognitive Dysfunction Memory Disorders Motor Activity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Aging Aging problems Cognition disorders in old age Cognitive change Cognitive decline Memory disorder, spatial Memory disorders Memory disorders in old age Memory impairment Memory loss Mild cognitive impairment

Contacts and locations

Locations

  • University of California, San Diego

    San Diego, California, 92122, United States

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