COGNITIVE CHANGE

This study tests a culturally tailored program that uses motivational interviewing and text messages to help Native American elders use their sleep apnea machines consistently. About 300 participants aged 50 and older from three Northern Plains Reservations will either receive st…

This study looks at how different types of exercise affect brain health and Alzheimer's risk in older African Americans. About 280 people aged 60 and older who are not very active will either take cardio-dance classes or strength, flexibility, and balance classes for 6 months. Re…

This study tests whether a gentle, non-invasive brain stimulation technique called high-definition transcranial direct current stimulation (HD-tDCS) can improve word-finding difficulties in people who have had a traumatic brain injury (TBI) at least one year ago. Researchers will…

This study tests whether combining the drug memantine with a structured exercise program can improve memory and thinking problems (often called 'chemo brain') in women undergoing chemotherapy for early-stage breast cancer. About 90 participants will be split into three groups: on…

This study looks at whether a 16-week high-intensity interval training (HIIT) program can help women with breast cancer maintain their thinking and memory skills while undergoing chemotherapy. About 30 women will be enrolled and will have their brain function, heart fitness, and …

This study tests whether customizing the electrical dose of ECT (electroconvulsive therapy) can better treat depression while protecting memory and thinking skills. About 50 older adults with depression will receive either a standard or personalized ECT amplitude. Researchers wil…

This study tests whether a 14-day mobile daily diary is a practical way to measure daily stress and thinking (cognitive) performance in breast cancer survivors from different racial backgrounds. Researchers will enroll 30 women aged 40 and older who are at least five years past t…

This study aims to find out if cognitive training (like brain games) can improve memory, attention, and problem-solving. It will enroll 1,600 healthy adults ages 18-30 or 60-85. Participants will complete up to 15 hours of computer-based tasks over 4-8 weeks. This is a research s…

This study looks at how being in a hot room affects the body, thinking, and mood of people with schizophrenia. Ten adults with or without schizophrenia will sit in a warm or hot room for six hours, doing light activity. The goal is to learn how heat impacts them, so better advice…

This study looks at how chemotherapy for ovarian cancer may change thinking and memory. Researchers will test 18 patients before, during, and after treatment using simple mental exercises. The goal is to better understand these side effects, not to test a new treatment.

This study looks at how practicing certain tasks can change the way you see, hear, and think. Researchers will test up to 1,140 healthy adults in two age groups (18-30 and 60-85) over 8 weeks. The goal is to understand how training improves skills like vision, reading, and attent…

This study looks at 65 adults with obstructive sleep apnea to see how three weeks of breathing therapy (ventilotherapy) changes their thinking skills, blood markers linked to brain health, and overall well-being. Participants will take thinking tests, give blood samples, and answ…

This study looks at how aging affects the ability to learn who to trust. Researchers will use real-time brain scans to train 68 older adults to improve trust-related learning. The goal is to see if this training can help older adults make smarter decisions about whom to trust.

This study looks at whether a 15-minute Shoonya meditation practice can help protect your thinking and focus after a night of poor sleep. Researchers will compare regular meditators with people who nap regularly. The goal is to see if meditation changes sleep patterns, heart rate…

This study looks at how different types of executive function training (like adding game features or coaching) improve thinking skills in teens with and without ADHD. About 780 adolescents aged 12-17 will complete 40 training sessions over 4 weeks, plus tests before, after, and 6…

This study checks if keeping indoor temperatures at 26°C (the recommended limit for older adults) can prevent dangerous heat strain and thinking problems in children aged 10 to 15 during a simulated school day. Ten kids will be exposed to both 26°C and 36°C conditions while doing…

This study looks at whether improving deep sleep can help protect the brain in older adults at risk for Alzheimer's disease. Researchers will ask 116 people aged 65-85 with mild sleep issues to spend less time in bed to naturally deepen their sleep. They will measure changes in m…

This study aims to find out if the recommended indoor temperature limit of 26°C (79°F) is safe for healthy, active young adults. Researchers will measure body temperature, heart strain, and thinking skills in 10 young volunteers during an 8-hour day in a warm room. Participants w…