COGNITIVE CHANGE
Clinical trials for COGNITIVE CHANGE explained in plain language.
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New supplement aims to shield menopausal brains from cognitive decline
Prevention OngoingThis study tests a plant-based supplement called PhytoSERM in 100 women aged 45-60 who are in or just past menopause. The goal is to see if it can prevent changes in brain activity and thinking skills that often happen during this time. Participants take either the supplement or …
Matched conditions: COGNITIVE CHANGE
Phase: PHASE2 • Sponsor: Roberta Brinton • Aim: Prevention
Last updated Jun 27, 2026 11:01 UTC
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Honey and nuts may beat sugar for blood sugar control
Symptom relief OngoingThis study compares how honey versus table sugar, each paired with almonds, affects blood sugar levels, hunger, and fullness in 58 healthy premenopausal women. Participants will eat snacks containing honey or sugar with or without almonds, and their glucose will be tracked with a…
Matched conditions: COGNITIVE CHANGE
Phase: NA • Sponsor: USDA, Western Human Nutrition Research Center • Aim: Symptom relief
Last updated Jun 27, 2026 13:00 UTC
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Hands-On therapy may clear Pain-Fueled brain fog
Symptom relief OngoingThis study looks at whether osteopathic manipulation, a type of hands-on treatment, can help adults aged 40 and older who have both pain and thinking problems like trouble with memory or focus. The researchers will measure changes in pain, thinking skills, and stress-related mark…
Matched conditions: COGNITIVE CHANGE
Phase: NA • Sponsor: Midwestern University • Aim: Symptom relief
Last updated Jun 27, 2026 07:53 UTC
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Brain scans reveal Stress's toll on aging minds
Knowledge-focused OngoingThis study looks at how stress influences long-term mood and thinking in 75 older adults with depression. Participants receive standard antidepressant treatment while researchers track their depression severity, memory, and brain activity using MRI scans. The goal is to understan…
Matched conditions: COGNITIVE CHANGE
Phase: PHASE4 • Sponsor: David Steffens • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:36 UTC
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Parkinson's study probes blood Pressure's role in brain function
Knowledge-focused TerminatedThis study aimed to understand how blood pressure changes when standing up affect thinking abilities and brain blood flow in people with Parkinson's disease. Researchers planned to compare participants with and without orthostatic hypotension (low blood pressure upon standing) us…
Matched conditions: COGNITIVE CHANGE
Phase: NA • Sponsor: University of California, San Diego • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:24 UTC
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Stanford launches study to predict brain fog after surgery in seniors
Knowledge-focused OngoingResearchers at Stanford are creating a database to better understand why some older adults experience memory or thinking problems after surgery with anesthesia. They will collect information from 250 patients aged 65 and older, including blood samples, brain wave recordings, and …
Matched conditions: COGNITIVE CHANGE
Sponsor: Stanford University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC
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100,000 volunteers join digital brain health study to catch dementia early
Knowledge-focused ENROLLING_BY_INVITATIONThis observational study will enroll 100,000 people over age 45 to track early signs of Alzheimer's and Parkinson's using smartphone-based tests, genetic data, and brain scans. Researchers aim to develop better ways to identify who is at risk before symptoms worsen. Participants …
Matched conditions: COGNITIVE CHANGE
Sponsor: Greece 2021 Committee • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:02 UTC
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Heart rhythm hiccups may fog your brain, study suggests
Knowledge-focused OngoingThis study looks at whether people with atrial fibrillation (AF) have temporary drops in thinking skills during an AF episode. Researchers will test 600 patients using tablet-based games that measure memory, attention, and decision-making while in AF and again after their heart r…
Matched conditions: COGNITIVE CHANGE
Sponsor: David Brunk, PA-C, MMS • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:54 UTC
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Brain fog after hip or knee replacement: how common and how long?
Knowledge-focused OngoingThis study follows 505 adults aged 50 and older who are having hip or knee replacement surgery. Researchers use a simple online card-game test to measure changes in memory, attention, and thinking before and up to 4.5 months after surgery. The goal is to find out how many people …
Matched conditions: COGNITIVE CHANGE
Sponsor: Dr. Stephen Choi • Aim: Knowledge-focused
Last updated Jun 26, 2026 14:02 UTC