Brain scans reveal Stress's toll on aging minds
NCT ID NCT05273996
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looks at how stress influences long-term mood and thinking in 75 older adults with depression. Participants receive standard antidepressant treatment while researchers track their depression severity, memory, and brain activity using MRI scans. The goal is to understand the links between stress, brain changes, and cognitive outcomes to inform future prevention strategies.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
antidepressants (sertraline, bupropion, desvenlafaxine)
What this could lead to
If successful, this study could reveal how stress impacts long-term mood and thinking in older adults with depression, pointing toward new ways to prevent cognitive decline.
What could go wrong
This is an observational analysis within a treatment study, not a test of a new drug. Results may not apply to all older adults with depression, and the small size (75 people) limits generalizability.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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UConn Health
Farmington, Connecticut, 06030, United States