Can tailoring ECT strength boost mood and spare memory?

NCT ID NCT05699226

Recruiting now Symptom relief Sponsor: University of New Mexico Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether adjusting the electrical amplitude of ECT (electroconvulsive therapy) to each person can better treat depression and reduce memory problems. Researchers will compare a personalized amplitude approach to the standard fixed 800 mA setting in 50 older adults with depression. Participants will have their depression severity and cognitive function measured before and after treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Soterix Medical Incorporated 4x1 adapter (device) and traditional ECT device
What this could lead to: If successful, this could lead to a more personalized ECT approach that reduces memory side effects while still treating depression effectively.
What could go wrong: This is a small early-stage study with only 50 participants, so results may not apply to everyone. The individualized amplitude approach may not show clear benefits over standard ECT.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

bipolar II disorder cognitive disorder Depression depressive disorder major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COGNITIVE CHANGE DEPRESSION ECT

Contacts and locations

Locations

University of New Mexico Health Science Center
RECRUITING

Albuquerque, New Mexico, 87110, United States

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