Online CBT may slow memory loss in depressed ICU seniors

NCT ID NCT06627894

Recruiting now Symptom relief Sponsor: Indiana University Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether internet-based cognitive behavioral therapy (CBT) can reduce depression and slow cognitive decline in older adults who survived an ICU stay. About 300 participants aged 50+ with depressive symptoms will receive either online CBT or standard depression education. The goal is to see if treating depression can help protect memory and thinking skills.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Internet-based cognitive behavioral therapy (Good Days Ahead)
What this could lead to: If successful, this could provide a practical, home-based treatment to improve mood and potentially slow memory decline in older adults after a serious illness.
What could go wrong: This is an early-stage trial testing a behavioral intervention, not a drug. The effect on cognitive decline is uncertain, and results may not apply to all ICU survivors.

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Conditions

The condition(s) this trial relates to.

Cognitive Dysfunction Depression depressive disorder subjective cognitive decline

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COGNITIVE DECLINE DEPRESSION

Contacts and locations

Locations

Eskenazi Hospital
RECRUITING

Indianapolis, Indiana, 46202, United States
IU Health Methodist Hospital
RECRUITING

Indianapolis, Indiana, 46202, United States

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