DELIRIUM - POSTOPERATIVE

This study compares light versus deep general anesthesia in older adults (65+ or Indigenous 55+) having major surgery. The goal is to see if lighter anesthesia reduces delirium—a common, serious complication that can cause confusion and long-term brain decline. About 2,766 partic…

This study tests a program of sleep improvement, brain exercises, and extended pain relief for older adults having heart surgery. The goal is to reduce confusion and delirium after surgery and improve long-term recovery. About 406 people aged 60 and older will take part, with hal…

This study tests a simple, family-led program called "Delirium Zero" to prevent confusion (delirium) in older adults after hip fracture surgery. About 140 patients over 65 will be randomly assigned to either standard care or the Delirium Zero protocol, which includes a wall clock…

This pilot study tests whether playing short, personalized audio messages to elderly patients after hip fracture surgery can help prevent confusion (delirium). About 30 participants aged 60 and older will listen to 2-minute recordings three times daily for three days. Researchers…

This study tests whether early occupational therapy—including motivating activities and sleep-promoting routines—can reduce delirium (sudden confusion) in patients after coronary artery bypass surgery. About 300 adults will be randomly assigned to receive either the special thera…

This study is testing different doses of a sedative drug called dexmedetomidine to see if it can help prevent or reduce confusion and memory problems in older adults after major hip or knee surgery. Researchers will compare the drug's effects against a standard pain medication in…

This study watches sleep and body rhythms in 150 older adults (70+) before major orthopedic surgery. Researchers collect blood samples and use a wrist monitor to see if sleep problems link to postoperative delirium. No treatment is given—the goal is to find early warning signs.

This study looks at whether a simple ultrasound of the brain (transcranial Doppler) can predict confusion or memory issues after heart bypass surgery. About 106 adults having planned bypass will have their brain blood flow measured during surgery. Researchers will then check for …

This study watches 80 adults aged 65 and older having planned laparoscopic surgery. It uses a non-invasive forehead sensor to measure brain oxygen use during surgery. The goal is to see if a reduced ability to use oxygen is linked to postoperative delirium (sudden confusion) in t…

This study looks at whether a special analysis of brain wave (EEG) recordings can tell the difference between older surgery patients who develop confusion (delirium) after their operation and those who do not. Researchers will enroll 90 patients aged 65 and older undergoing gener…

This study is for adults aged 65 and older having major surgery. Researchers want to see if certain substances in the blood, measured right after surgery, can predict whether a patient will experience postoperative delirium—a state of sudden confusion. The goal is to find a relia…