DELIRIUM - POSTOPERATIVE

This trial investigates whether playing a virtual reality (VR) cognitive stimulation game can help older adults with mild memory problems stay mentally sharp and avoid delirium after major surgery. Participants, aged 65 and older, will use an Oculus Quest 2 headset for 20 minutes…

This study tests whether giving blood transfusions quickly when hemoglobin drops can prevent delirium (sudden confusion) in patients 75 and older after hip fracture surgery. About 198 participants will be randomly assigned to either early transfusion or standard care. Researchers…

This study compares light versus deep general anesthesia in older adults (65+ or Indigenous 55+) having major surgery. The goal is to see if lighter anesthesia reduces delirium—sudden confusion—and long-term memory problems. About 2,766 participants will be randomly assigned to o…

This study tests a simple program for people aged 60+ having heart surgery. Before surgery, participants will get help improving sleep and do brain exercises. After surgery, they receive extra pain relief. The goal is to see if this bundle reduces delirium (sudden confusion and a…

This study tests a simple, family-led protocol called 'Delirium Zero' to prevent delirium (sudden confusion) in older adults after hip fracture surgery. About 140 patients over 65 will be randomly assigned to either standard care or the Delirium Zero protocol, which includes an o…

This study tests whether early occupational therapy—focused on motivating activities and sleep routines—can reduce delirium (sudden confusion) in patients after heart bypass surgery. Researchers will compare the therapy to standard care in 300 adults. The goal is to see if this a…

This study looks at whether a drug called dexmedetomidine can help prevent confusion and memory loss in older adults after major leg surgery. Researchers will compare different doses of the drug to standard pain medicine in 75 patients. The goal is to find the best dose to protec…

This pilot study tests whether personalized audio-recorded messages, played three times daily for the first three days after hip fracture surgery, can help prevent delirium in patients aged 60 and older. The study will enroll 30 participants and focus on whether the intervention …

This study looks at how sleep problems before heart surgery might impact recovery in 144 adults. Researchers will collect blood and stool samples before and after surgery to measure changes in metabolism, inflammation, and gut bacteria. The goal is to understand why poor sleep le…

This study looks at whether analyzing brain-wave patterns (EEG) can help predict postoperative delirium—a state of confusion—in older adults after surgery. Researchers will collect EEG data before and during surgery from 90 patients aged 65 and older. The goal is to find a way to…

This observational study is looking at whether the brain's ability to use oxygen during surgery is linked to postoperative delirium in adults aged 65 and older. Researchers will use a non-invasive forehead sensor to measure brain oxygen levels during routine laparoscopic surgery …

This study is testing whether a simple brain ultrasound, called transcranial Doppler, can predict confusion or memory loss after heart bypass surgery. Researchers will measure blood flow in the brain during surgery and check patients for delirium and cognitive changes afterward. …

This study is looking at whether certain substances in the blood can help predict postoperative delirium—a state of confusion that can occur after surgery in older adults. Researchers will measure specific biomarkers before and after surgery in 1,170 patients aged 65 and older un…

This study looks at whether sleep patterns in the two weeks before major orthopedic surgery can help predict delirium (sudden confusion) after the operation. Researchers will ask 150 older adults (70+) to wear a watch that tracks sleep and to give blood samples. The goal is to fi…