Sleep drug may shield Seniors' brains after heart surgery
NCT ID NCT06192615
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether a drug called dexmedetomidine, which promotes sleep, can prevent delirium (sudden confusion) in patients aged 60 and older after heart surgery. Delirium is common in the ICU and can lead to longer hospital stays and worse recovery. The trial will compare the drug to a placebo in 1800 participants to see if it helps protect brain function.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Dexmedetomidine (Precedex)
What this could lead to
If it works, this could provide a way to prevent delirium and improve recovery in older adults after heart surgery.
What could go wrong
This is a large phase 3 trial, but delirium is complex and the drug may not work for everyone. Side effects like low blood pressure or slow heart rate are possible.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Beth Israel Deaconess Medical Center
RECRUITINGBoston, Massachusetts, 02215, United States
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Brigham and Women's Hospital
RECRUITINGBoston, Massachusetts, 02215, United States
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Cedars-Sinai Medical Center
NOT_YET_RECRUITINGLos Angeles, California, 90048, United States
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Columbia University Medical Center
RECRUITINGNew York, New York, 10032, United States
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Duke University Hospital
RECRUITINGDurham, North Carolina, 27710, United States
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Massachusetts General Hospital
RECRUITINGBoston, Massachusetts, 02114, United States
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Montefiore Medical Center
NOT_YET_RECRUITINGThe Bronx, New York, 10467, United States
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Northwestern University Feinberg School of Medicine
RECRUITINGChicago, Illinois, 60611, United States
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University of California San Francisco
NOT_YET_RECRUITINGSan Francisco, California, 94117, United States
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University of Iowa Carver College of Medicine
RECRUITINGIowa City, Iowa, 522421320, United States
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University of Maryland School of Medicine
RECRUITINGBaltimore, Maryland, 21201, United States
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University of Nebraska Medical Center
RECRUITINGOmaha, Nebraska, 68198, United States
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Vanderbilt University Medical Center
RECRUITINGNashville, Tennessee, 37232, United States
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Washington University School of Medicine
NOT_YET_RECRUITINGSt Louis, Missouri, 63110, United States
Contact