Can an enzyme gel dissolve burned tissue without surgery?
NCT ID NCT06628037
First seen Aug 07, 2026 · Last updated Aug 07, 2026
Summary
This trial tests a gel made from the enzyme SN514 to see if it can safely and effectively remove dead tissue from deep partial-thickness burns. Adults with suitable burns will receive daily applications of the gel for up to seven days, with different concentrations tested in small groups. The goal is to find the highest dose that is well-tolerated and to measure how much dead tissue is removed over time.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- SN514-066b, an enzyme gel applied to burn wounds to remove dead tissue
- What this could lead to
- If successful, this could provide a less painful, non-surgical way to clean deep burn wounds, potentially improving healing and reducing scarring.
- What could go wrong
- This is an early-phase dose-finding study with a small number of participants. The enzyme may not work as hoped, or it could cause significant side effects like pain or irritation.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
USAISR Burn Center
San Antonio, Texas, 78234, United States
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