Lab-Grown skin could transform burn care for children
NCT ID NCT03229564
First seen Aug 06, 2026 · Last updated Aug 07, 2026 · Updated 1 time
Summary
This trial is testing a lab-grown skin substitute called denovoSkin in children with deep burns. The engineered skin is made from the child's own cells and is compared to the standard treatment of using a split-thickness skin graft. The goal is to see if denovoSkin can cover burns more effectively and safely, potentially reducing the amount of healthy skin needed for grafting. The study involves 12 children under 12 years old who have deep partial or full-thickness burns requiring surgical coverage.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- an autologous bio-engineered dermo-epidermal skin substitute called denovoSkin (EHSG-KF)
- What this could lead to
- If successful, this could offer a more effective and safer way to cover deep burns in children, potentially reducing the need for multiple surgeries and improving healing outcomes.
- What could go wrong
- This is an early-stage trial with only 12 children, so results may not apply broadly. The engineered skin might not integrate as well as standard grafts, and there is a risk of infection or rejection.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Dipartimento di Chirurgia Pediatrica Ospedale dei bambini Vittorio Buzzi
Milan, Italy
-
Rode Kruis Ziekenhuis
Beverwijk, 1940, Netherlands
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Unità di Chirurgia Plastica e Ustioni Ospedale Santobono
Naples, Italy
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University Children's Hospital Zurich
Zurich, 8032, Switzerland
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a dissolvable dressing get burn patients to skin grafts faster?
- Could a special dressing make skin grafts unnecessary for burns?
- Can tiny skin grafts heal wounds without leaving a second scar?
- Lab-Grown skin could transform burn healing
- Can Lab-Grown skin permanently replace severe burn wounds?
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