Can a common antidepressant calm burn damage? early study investigates
NCT ID NCT07640061
First seen Jun 27, 2026 · Last updated Jul 17, 2026 · Updated 1 time
Summary
This pilot study tests whether a single 75mg dose of amitriptyline can reduce the release of microvesicle particles (tiny substances) from skin after a very small, controlled burn. Twenty healthy adults will receive either amitriptyline or a placebo, then a small heated rod creates a minor burn on their forearm. Skin samples will be taken to measure particle release. The study aims to understand the body's response to injury, not to treat burns directly.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- amitriptyline
- What this could lead to
- If it works, this could point toward a way to reduce harmful particles released after burns, potentially improving healing.
- What could go wrong
- This is a very early, small pilot study with only 20 people. It tests a tiny controlled burn, not real-world injuries, and may not translate to actual burn care.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
Locations
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Wright State University - Pharmacology Translational Unit
Fairborn, Ohio, 45324, United States
Contact Email: •••••@•••••
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