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Can a common steroid save lives after severe burns?

NCT ID NCT06968559

Recruiting now Disease control Sponsor: Nantes University Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This Phase 3 trial tests whether giving the steroid dexamethasone early after a severe burn can prevent major complications like lung or kidney failure and reduce death. About 478 adults with burns covering at least 20% of their body and on a breathing machine will receive either dexamethasone or a placebo for five days. The study aims to see if calming the body's overwhelming inflammation can improve outcomes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Dexamethasone (a corticosteroid drug)
What this could lead to
If it works, this could provide a simple, low-cost treatment to reduce organ failure and death after severe burns.
What could go wrong
This is a single Phase 3 trial; previous studies were small or retrospective. Dexamethasone may not reduce complications and could increase infections or blood sugar issues.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

burn

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SEVERE BURNS

Contacts and locations

Locations

  • Aphm Hopital La Timone

    NOT_YET_RECRUITING

    Marseille, 13005, France

  • CHR Metz

    NOT_YET_RECRUITING

    Metz, 57085, France

  • CHU Bordeaux

    NOT_YET_RECRUITING

    Pessac, 33604, France

  • CHU Lille

    NOT_YET_RECRUITING

    Lille, 59037, France

  • CHU Montpellier

    NOT_YET_RECRUITING

    Montpellier, 34295, France

  • CHU Toulouse

    NOT_YET_RECRUITING

    Toulouse, 31059, France

  • CHU Tours

    NOT_YET_RECRUITING

    Chambray-lès-Tours, 37170, France

  • CHU de Lyon

    NOT_YET_RECRUITING

    Lyon, 69437, France

  • Chu Nantes

    RECRUITING

    Nantes, 44093, France

  • HU Saint-Louis Lariboisière

    NOT_YET_RECRUITING

    Paris, 75475, France

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