Can a single injection numb the chest or belly? a nerve block under the microscope

NCT ID NCT04401007

Completed Knowledge-focused Sponsor: University Health Network, Toronto Source: ClinicalTrials.gov ↗

First seen Jul 31, 2026 · Last updated Jul 31, 2026

Summary

This study tests a newer nerve block technique called the erector spinae plane (ESP) block, which involves injecting local anesthetic near the spine to numb the chest or abdominal wall. Healthy volunteers will receive the block with two different doses of lidocaine on separate visits to see how long and how completely it blocks sensation. The goal is to understand how well the block works and whether the dose affects its coverage, which could improve pain management after surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Erector spinae plane (ESP) block with lidocaine and epinephrine
What this could lead to: If successful, this could help refine the ESP block technique, leading to more consistent and effective pain relief after surgery.
What could go wrong: This is a small, early-stage study in healthy volunteers, so results may not apply to patients. The block may not provide consistent coverage, and there are risks like infection or nerve damage.

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Conditions

The condition(s) this trial relates to.

agnosia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PAIN MANAGEMENT

Contacts and locations

Locations

University Health Network

Toronto, Ontario, M5T 2S8, Canada

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Other studies related to the condition(s) this trial covers.