PAIN MANAGEMENT

This trial tests whether a fentanyl nasal spray can reduce pain during eye exams for retinopathy of prematurity (ROP) in preterm infants. About 58 babies born at or before 31 weeks will receive either fentanyl or a saltwater placebo before their routine exam, along with standard …

This pilot study will test whether oral ketamine can control pain as well as oxycodone in emergency department patients who need extra pain medication. Sixty adults with certain types of pain will be randomly assigned to receive either drug. Researchers will measure changes in pa…

This study compares two types of nerve blocks—quadro-iliac plane block and supra-inguinal fascia iliaca compartment block—for pain after total hip replacement. Sixty adults scheduled for hip surgery will receive one of the blocks along with spinal anesthesia. Researchers will mea…

This study tests a device called BreEStim that uses electrical stimulation timed with your breathing to reduce nerve pain after spinal cord injury. About 66 adults with long-term spinal cord injury and stable pain will receive either active or sham treatment. The goal is to see i…

This study compares two types of nerve blocks used to manage pain after total hip replacement. Sixty adults having hip replacement will receive either a quadro-iliac plane block or a PENG block combined with a lateral femoral cutaneous nerve block. Researchers will measure pain s…

This study tests whether a numbing injection called a superficial parasternal intercostal plane block (SPIPB) can widen the internal thoracic artery, making it easier for surgeons to harvest during coronary artery bypass grafting (CABG). The trial involves 50 adults aged 22 to 65…

This study tests whether a paracervical block (an injection near the cervix) containing ketorolac and lidocaine can reduce pain during placement of osmotic dilators, which are used to prepare the cervix for a second-trimester abortion. About 76 participants will be randomly assig…

This study tests a special anesthesia method that uses fewer opioids during spine surgery in people aged 65 and older. The goal is to see if it lowers pain and the need for strong painkillers after surgery. Half the participants will get this opioid-sparing anesthesia, and the ot…

This study tests whether a long-acting form of the numbing drug bupivacaine (liposomal bupivacaine) can reduce pain and the need for strong opioid painkillers after lung transplant surgery. 88 adults receiving a double lung transplant will get an intercostal nerve block either wi…

This study will develop and test a new digital pain rehabilitation program for people with spinal cord injury (SCI) who have chronic pain. The program is based on a biopsychosocial model, which looks at physical, emotional, and social factors. The study will enroll 32 adults who …

This trial tests whether a combined nerve block can improve pain relief after total knee replacement while preserving leg strength. 240 adults scheduled for knee surgery will receive either the combined block or a standard saphenous nerve block. Researchers will measure opioid us…

This study compares three pain management approaches for 120 adults undergoing coronary artery bypass surgery: standard painkillers alone, standard plus a parasternal nerve block, or standard plus both parasternal and adductor canal blocks. The goal is to see if adding these nerv…

This study tests whether listening to a 1- or 2-minute guided mindfulness audio can reduce pain in people waiting for orthopedic care. 300 adults will be randomly assigned to one of two mindfulness exercises or a control. The goal is to see if a brief, easy-to-use technique can m…

This study will test whether a video game that guides children through breathing exercises can reduce pain, fear, and anxiety during a routine blood draw. About 60 children aged 7 to 12 will be randomly assigned to either play the breathing game during the procedure or receive st…

This study compares different numbing methods to reduce pain during dental cavity treatment. About 204 adults with tooth decay will receive either a light-based device, a numbing gel, or a placebo before local anesthesia. Researchers will measure pain during and after the procedu…

This study will test whether doing Pilates exercises at home via video calls for 16 weeks can help people with multiple sclerosis (MS) walk farther and faster, improve balance, reduce fatigue and pain, and boost mood and thinking. About 50 adults with mild to moderate MS who can …

This study tests a device called TUNES, which delivers gentle electrical stimulation through a menstrual disc to nerves near the uterus. The goal is to see if it can reduce pain and the need for pain medication in 60 women after uterine fibroid embolization. Participants will be …

This study compares continuous regional anaesthesia (a numbing medicine delivered through a tiny tube near the nerves) with standard pain management for people who have war-related leg injuries. About 150 adults will take part, and researchers will measure pain levels and opioid …

This study tests whether watching a 360° relaxing nature video through a VR headset during a Pap smear can lower pain and anxiety. Sixty women aged 18–65 will be randomly assigned to either the VR group or standard care. Researchers will measure pain and anxiety levels to see if …

This study tests whether a special light therapy (photobiomodulation) can reduce pain and improve jaw function in people with myofascial temporomandibular disorder (TMD), a condition causing muscle pain in the face and jaw. About 140 adults will be split into three groups: light …

This study will compare three types of anesthesia for people having ankle surgery: total intravenous anesthesia with a nerve block, general anesthesia with a nerve block, and spinal anesthesia. The goal is to see which method allows patients to recover and leave the hospital the …

This study tests whether a special way of talking by nurses can help adults with burns feel less pain and worry during dressing changes. About 62 people will be split into two groups: one gets the special comfort talk, the other gets usual care. The goal is to see if simple, supp…

This study looks at whether giving a local anesthetic to the abdominal wall at the start of robotic prostate surgery, rather than at the end, can reduce the amount of strong painkillers (opioids) needed during the operation. About 50 adults with prostate cancer or benign prostate…

This study compares two injections—botulinum toxin (Botox) and local anesthetic—to see which better relieves pain from nerve damage (neuroma) after limb injury or amputation. About 100 adults with moderate to severe pain will receive one injection and be followed for 8 weeks. The…

This study tests whether using a cold spray or a Buzzy device (a vibrating cold pack) can reduce pain and fear during penicillin injections. Ninety adults receiving intramuscular penicillin will be randomly assigned to one of three groups: cold spray, Buzzy device, or standard ca…

This early-stage trial will give a single 10 mg dose of psilocybin to 70 adults recovering from trauma surgery who also have opioid use disorder. Researchers want to see if it's safe and practical to give psilocybin in the hospital, and how it affects pain, mood, and opioid use o…

This study tests two non-drug methods—a device called ShotBlocker and a tapping technique called Helfer—to see if they can reduce pain and fear during hormone injections in breast cancer patients. 99 women will be randomly assigned to one of three groups. The goal is to find a si…

This study tests if giving the numbing drug bupivacaine through a chest tube can reduce pain after minimally invasive lung surgery. About 249 adults having video-assisted thoracoscopic surgery will receive either a low or high dose of bupivacaine, or a placebo. The main goal is t…

This trial tests two different nerve block methods to control pain after laparoscopic gallbladder removal. Sixty adults undergoing elective surgery will receive either a newer single-puncture block or an external oblique intercostal plane block, while a control group gets only st…

This study compares opioid-free anesthesia to standard opioid-based anesthesia for people having laparoscopic pancreatic surgery. The goal is to see if avoiding opioids leads to less pain and lower opioid use after surgery. Two hundred adults aged 18-80 will take part, and resear…

This study tests two nasal sprays, sufentanil and ketamine, to see which works better for severe pain from injuries like broken bones in children aged 6 to 17. Both sprays are given in the emergency room along with standard care. The goal is to find a fast, needle-free way to eas…

This study tests a new device called Medstrom that monitors pain, sedation, and muscle relaxation all in one during laparoscopic colon cancer surgery. Thirty patients will be randomly assigned to either the Medstrom device or standard monitoring. The goal is to see if the device …

This study compares opioid-free anesthesia to standard opioid anesthesia in 200 adults undergoing pancreatic surgery. The goal is to see if avoiding opioids during surgery can still control pain well and reduce the need for painkillers afterward. Participants will have their pain…

This study tests whether two common antioxidants, N-Acetylcysteine (NAC) and Alpha-Lipoic Acid (ALA), can improve pain control and reduce the need for strong painkillers after laparoscopic appendix removal. 180 adults aged 18-65 undergoing this surgery will receive either NAC, AL…

This study tests whether wearing virtual reality (VR) glasses during needle insertion can reduce pain and anxiety in hemodialysis patients. 150 adults with end-stage kidney disease will either receive standard care or watch a calming 360-degree underwater video through VR goggles…

This study tests whether a simple questionnaire-based pain calculator can help doctors choose the right pain medication for women undergoing in-office gynecologic procedures like IUD insertion or biopsy. About 200 participants will either get pain meds based on the calculator or …

This study tests whether a device that gently stimulates a nerve in the ear can help reduce the amount of strong painkillers (opioids) needed after major abdominal surgery. About 108 adults will receive either the real stimulation or a sham version while in the intensive care uni…

This Phase 2 trial tests a topical anesthetic marker applied to the skin to reduce pain from needle pricks. Twenty adults will have the marker applied to their forearm, and pain will be measured every 10 minutes for 40 minutes compared to untreated skin. The goal is to see how we…

This study tests two quick, drug-free mental techniques—body-scan mindfulness and guided imagery—to see if they can lower acute pain in adults staying in short-stay hospital wards. 160 participants will be randomly assigned to one of these techniques or a brief educational sessio…

This study tests whether listening to music during a transperineal prostate biopsy can lower pain and anxiety. About 78 men over age 50 with suspected prostate cancer will be randomly assigned to have music or no music during the procedure. The goal is to see if music helps patie…

This study compares three types of physical therapy for adults aged 20-60 with prolonged shoulder pain. Participants are randomly assigned to routine therapy, tendon-specific exercises, or therapy that also addresses psychological factors. The goal is to see which approach best h…

This study looks at whether watching a virtual reality (VR) video can help children aged 7 to 12 feel less pain and fear when getting an IV. About 150 kids having day surgery will be randomly placed into one of three groups: watching an aquarium video, a kaleidoscope video, or ge…

This study tests whether using a virtual reality (VR) headset can reduce anxiety before total knee replacement surgery and lessen pain afterward. 64 patients will watch educational videos about the operating room before surgery and relaxing nature videos after surgery. The goal i…

This study tests whether injecting a local anesthetic (mepivacaine) into the ligaments around the cervix can reduce pain during an outpatient hysteroscopy. About 70 women who have never had a hysteroscopy will be randomly assigned to receive either the anesthetic or a placebo. Th…

This study tests whether Su Jok therapy—a technique using hand massage and seeds on specific points—can lower pain in newborns during a heel lance blood test. Sixty-six full-term babies will be randomly assigned to receive the therapy or standard care. Pain will be measured using…

This study compares a computer-controlled anesthetic device (SleeperOne) to a traditional syringe for numbing kids' teeth before extraction. 28 children aged 3-5 will be randomly assigned to one method. Pain, anxiety, and heart rate will be measured to see if the device makes the…

This study tests whether letting children watch cartoons or giving them a gentle foot massage before surgery can reduce their nausea, pain, and anxiety. About 105 children aged 4 to 6 will be assigned to one of three groups: watching a cartoon, receiving reflexology, or standard …

This study tests whether using ChatGPT alongside traditional bedside training helps nursing students learn pain management better. 156 students will be randomly assigned to either AI-assisted or standard teaching. Researchers will measure changes in knowledge, attitudes, competen…

This study follows 120 people with laryngeal cancer to see how their quality of life, voice, swallowing, pain, and mood change before treatment and at 3, 6, and 12 months after. Researchers will use questionnaires to track these changes. The goal is to better understand recovery …

This study asks children aged 6-16, their parents, and clinicians to vote on the most important research topics in pediatric anesthesia and perioperative medicine. Over 1,000 participants in Switzerland will complete online surveys to create a ranked list of the top 10 priorities…

This study looks at a new way to assess pain in intensive care patients who are on breathing machines and cannot speak. It uses a special tool (AlgiScan) and a behavioral checklist to adjust pain medicine more safely. Researchers will compare data from 400 adults to see if the ne…

This study will test whether a low power LASER, used for pain relief, can also change heart rate and the body's automatic nervous system. Researchers will monitor 45 healthy volunteers before, during, and after LASER treatment. They will also use a numbing gel to see if the effec…

This study looks at two types of nerve blocks—TAP and rectus sheath—used to manage pain after a hysterectomy through a bikini-line cut. Researchers will measure how much of the incision each block numbs and compare pain scores and morphine use. About 30 women having planned surge…

This study looks at how low body temperature during lung cancer surgery (using a tiny camera) affects pain and complications after the operation. About 144 adults having this surgery will have their temperature tracked continuously. The goal is to understand if getting cold durin…

This study looks at how opioid painkillers affect the success of immunotherapy in 100 people with advanced lung cancer who have moderate to severe pain. Researchers want to see if better pain control helps immunotherapy work better, and whether opioids themselves change the treat…