PAIN MANAGEMENT

This study tests whether watching a calming 360-degree nature video through a VR headset during a Pap smear can lower pain and anxiety. About 60 women will be randomly assigned to either use VR or receive standard care. The goal is to find a simple, non-drug way to make this impo…

This study tests whether two common antioxidants, N-Acetylcysteine (NAC) and Alpha-Lipoic Acid (ALA), can improve pain control after laparoscopic appendectomy. 180 adults undergoing this surgery will receive either NAC, ALA, or a placebo alongside standard painkillers. The goal i…

This study tests a special marker that contains numbing medicine. When applied to the skin, it may reduce pain from needle pricks. Twenty adults will have the marker applied to their forearm and then receive light pricks every 10 minutes for 40 minutes to see how well and how fas…

This study compares three physical therapy approaches for adults aged 20-60 with shoulder pain lasting at least four weeks. Participants are randomly assigned to routine therapy, tendon-specific exercises, or therapy that also addresses emotional factors. The goal is to see which…

This study tests whether a vaginal injection of ketorolac (an anti-inflammatory) plus lidocaine (a numbing drug) can reduce pain when placing osmotic dilators for second-trimester abortion. About 76 adults will receive either the combined injection or standard care. The goal is t…

This study compares three types of anesthesia for people having ankle arthroscopy (a minimally invasive surgery). The goal is to find which method helps patients wake up and go home the fastest. Two hundred adults aged 18 to 65 will be randomly assigned to receive either total in…

This study tests a new device called Medstrom that monitors pain, sedation, and muscle relaxation all in one during laparoscopic colon cancer surgery. It aims to replace multiple separate monitors, reduce delays, and lower costs. About 30 adults having elective surgery will be ra…

This study tests whether gentle electrical stimulation to nerves near the uterus can reduce pelvic pain after a procedure to treat uterine fibroids. About 60 women will receive either active stimulation, a sham device, or standard care. The goal is to see if this approach lowers …

This study compares two non-drug methods—a device called ShotBlocker and a tapping technique called Helfer—against standard care for reducing pain and fear during hormone injections in breast cancer patients. 99 women will be randomly assigned to one of three groups. The goal is …

This study tests whether listening to music during a prostate biopsy can lower pain and anxiety. About 78 men over 50 who need a first-time biopsy will be randomly assigned to either listen to music or not during the procedure. Researchers will compare pain scores, stress levels,…

This study will test two different ways to numb the belly wall after gallbladder removal surgery. The goal is to see which method better controls pain and reduces the need for strong painkillers. About 60 adults having planned gallbladder surgery will take part.

This study will test whether using virtual reality (VR) can help reduce anxiety before knee replacement surgery and manage pain afterward. About 64 adults scheduled for knee replacement will use VR for relaxation and distraction. Researchers will measure pain levels and anxiety t…

This study looks at whether giving a local anesthetic to the abdominal wall at the start of robotic prostate surgery, rather than at the end, can reduce the amount of strong painkillers (opioids) needed during the operation. About 50 adults with prostate cancer or benign prostate…

This study tests whether a special way for nurses to talk with patients during burn dressing changes can lower pain and anxiety. About 62 adults with second- or third-degree burns will take part. The nurse will use a structured communication model during three dressing sessions, …

This study looks at whether using a cold spray or a vibrating Buzzy device can help reduce pain and fear during penicillin injections. About 90 adults getting the shot will be randomly placed into one of three groups: cold spray, Buzzy device, or no extra help. Their pain and fea…

This study tests two brief, non-drug mental techniques—body-scan mindfulness and guided imagery—to see if they can quickly reduce acute pain in adults staying in short-stay hospital wards or emergency observation units in Boyacá, Colombia. About 160 participants will be randomly …

This study tests whether injecting a numbing medicine (bupivacaine) into the chest can reduce pain from chest tubes after lung surgery. About 249 adults having minimally invasive lung surgery will receive either a low or high dose of bupivacaine or a placebo. The goal is to find …

This study tests whether avoiding opioid drugs during anesthesia can lead to less pain and fewer side effects after laparoscopic pancreatic surgery. About 200 adults will be randomly assigned to receive either opioid-free or standard opioid anesthesia. The goal is to see if the o…

This study tests two different nasal sprays (sufentanil and ketamine) to see which works better for severe pain from injuries like broken bones in children aged 6 to 17. Both sprays are given in the emergency room along with standard care. The goal is to find a fast, needle-free …

This study will test if a continuous numbing medicine (regional anesthesia) works better than standard painkillers for people with war-related leg injuries. About 150 adults will take part, and researchers will measure pain levels and how much opioid medication they need. The goa…

This study compares two ultrasound-guided nerve blocks (RIFPB and TAPB) for pain control after laparoscopic gallbladder removal. 90 adults scheduled for surgery will receive one of the two blocks, and their pain levels and opioid use will be tracked for 24 hours. The goal is to s…

This study tests whether watching fun virtual reality videos (like an aquarium or kaleidoscope) can lower pain and fear in children aged 7 to 12 when they get an IV. About 150 kids having day surgery will be split into three groups: two that watch different VR videos during the p…

This study will test whether a 16-week Pilates program done at home via video calls can improve walking, balance, fatigue, and pain in people with multiple sclerosis (MS). About 50 adults with mild to moderate MS will be assigned to either the Pilates group or a waitlist. Researc…

This study will test whether a video game that guides children through breathing exercises can reduce pain, fear, and anxiety during routine blood draws. About 60 children aged 7 to 12 will be randomly assigned to either use the BREATHING+ system during the procedure or receive s…

This study tests if a special light therapy (photobiomodulation) can reduce pain in the jaw and face muscles caused by temporomandibular disorder (TMD). About 140 adults with this condition will receive either light therapy alone, light therapy plus exercises, or a fake light the…

This study tests whether using virtual reality (VR) goggles during needle insertion can lower pain and anxiety in people on hemodialysis. About 150 adults with end-stage kidney disease will be randomly assigned to receive standard care or VR distraction. The goal is to see if a s…

This study looks at whether giving local anesthesia (a numbing medicine) before a hysteroscopy can lower the pain women feel during the procedure. About 70 women who have never had a hysteroscopy will be randomly assigned to receive either the numbing medicine or a placebo (salt …

This study compares two ultrasound-guided nerve block techniques—Quadro-iliac Plane Block and Transversus Abdominis Plane Block—to see which provides better pain relief after inguinal hernia repair. About 60 adults aged 18 to 65 will take part. The goal is to reduce pain and impr…

This study compares opioid-free anesthesia to standard opioid-based anesthesia in 200 adults undergoing pancreatic surgery. The goal is to see if avoiding opioids during surgery still controls pain well and reduces the need for painkillers afterward. Participants will have their …

This early-stage trial will test whether a single dose of psilocybin (the active ingredient in magic mushrooms) is safe and practical for adults with opioid use disorder who are recovering from trauma surgery. Seventy participants will receive the drug during their hospital stay …

This study tests different numbing gels and techniques to see which one works best to reduce pain during and after cavity treatment. About 204 healthy adults with tooth decay will be randomly assigned to receive one of the numbing methods before their dental procedure. Participan…

This study tests if a small device that gently stimulates a nerve in the ear can help people use fewer strong painkillers (opioids) after major abdominal surgery. About 108 adults will be randomly assigned to receive either the real stimulation or a fake version. Researchers will…

This study tests if listening to a short audio-guided mindfulness exercise can help reduce pain for people waiting to see an orthopedic doctor. About 300 adults will be randomly assigned to different lengths of mindfulness practice. The goal is to see if even a brief session can …

This study tests whether using a risk-stratification calculator to choose pain medications before in-office gynecologic procedures (like IUD insertion or biopsy) can lower pain and improve satisfaction. About 200 adults will either get pain meds based on the calculator or their d…

This study looks at whether watching cartoons and getting foot reflexology can help children aged 4 to 6 feel less anxious, nauseous, and in pain after planned surgery. About 105 kids will be involved. The goal is to find simple, drug-free ways to improve recovery.

This study compares two injections—botulinum toxin (Botox) and local anesthetic—to see which better relieves pain from neuromas (painful nerve endings) after limb trauma or amputation. About 100 adults with moderate to severe pain will receive one injection and be followed for 8 …

This study compares a computer-controlled anesthesia device (SleeperOne® 5) with a traditional syringe for numbing children's mouths before tooth extraction. About 28 children aged 3-5 will take part, and their pain, anxiety, and heart rate will be measured. The goal is to see if…

This study tests whether watching a guided imagery video about acupuncture can help adults feel less pain after spinal surgery. 120 participants will watch a 30-minute video daily for a week after their operation. Researchers will compare their pain levels and painkiller use to t…

This study will test if Su Jok therapy, a gentle hand stimulation technique, can reduce pain in newborns during a routine heel lance blood draw. About 66 full-term babies will be randomly assigned to receive Su Jok therapy or standard care. Pain will be measured using a validated…

This study aims to find out which of two common nerve-blocking techniques works better for pain relief after an abdominal hysterectomy. Researchers will observe 30 patients having this surgery to see how well each method numbs the surgical area and reduces pain. The goal is to he…

This study looks at whether a gentle, non-invasive low power LASER can change heart rate and the body's automatic nervous system. Researchers will monitor 45 healthy volunteers aged 20-45 using ECG and pulse sensors before, during, and after LASER exposure. They will also use a n…

This study asks children aged 6-16, their parents, and healthcare workers to vote on the most important research topics in pediatric anesthesia and surgery care. The goal is to create a shared list of top 10 priorities to guide future studies. No treatments or medications are tes…

This study looks at how low body temperature during lung cancer surgery (using a tiny camera) affects pain and complications after the operation. About 144 people having this surgery will be watched closely. The goal is to understand if staying warm during surgery can lead to bet…

This study looks at whether using ChatGPT alongside regular bedside training can improve how nursing students understand and manage pain. About 156 nursing students will be split into two groups: one using ChatGPT-assisted sessions and the other using traditional methods. Researc…

This study looks at how opioid painkillers influence the effectiveness of immunotherapy in people with advanced lung cancer and moderate to severe pain. Researchers will track 100 participants to see if better pain control leads to better cancer outcomes. The goal is to understan…

This study looks at a new way to assess pain in intensive care unit (ICU) patients who are on breathing machines and cannot speak. It uses a special tool (AlgiScan) and a behavioral checklist to better measure pain and adjust painkillers. The goal is to see if this approach reduc…

This study follows 120 people with laryngeal cancer to see how their quality of life, voice, swallowing, pain, and mood change over a year after treatment. Participants fill out questionnaires before treatment and at 3, 6, and 12 months after. The goal is to better understand rec…