New nerve block could reduce opioid use after knee surgery

NCT ID NCT07629388

Not yet recruiting Symptom relief Sponsor: Ramsay Générale de Santé Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This trial tests whether a combined nerve block can improve pain relief after total knee replacement while preserving leg strength. 240 adults scheduled for knee surgery will receive either the combined block or a standard saphenous nerve block. Researchers will measure opioid use, pain levels, and how quickly patients can stand and walk after surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Ropivacaine with clonidine and dexamethasone
What this could lead to: If it works, this could offer a better way to manage pain after knee replacement, reducing opioid use and helping patients recover leg strength faster.
What could go wrong: This is a small, early-stage trial comparing two nerve block techniques. The combined block may not provide better pain relief or could cause unexpected side effects. Results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

agnosia Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PAIN AFTER TOTAL KNEE ARTHROPLASTY PAIN MANAGEMENT

Contacts and locations

Locations

Hôpital privé Dijon Bourgogne

Dijon, 21000, France

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