Nasal fentanyl spray could ease painful eye exams for premature babies
NCT ID NCT07112430
First seen Jun 30, 2026 · Last updated Jul 01, 2026 · Updated 1 time
Summary
This trial tests whether a fentanyl nasal spray can reduce pain during eye exams for retinopathy of prematurity (ROP) in preterm infants. About 58 babies born at or before 31 weeks will receive either fentanyl or a saltwater placebo before their routine exam, along with standard comfort measures like sugar water and swaddling. Researchers will measure pain scores and monitor heart rate, oxygen levels, and side effects to see if the spray is safe and effective.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- fentanyl citrate (intranasal spray)
- What this could lead to
- If effective, this could provide a safe, non-invasive way to ease pain during routine eye exams for premature babies.
- What could go wrong
- This is an early-phase trial with only 58 infants, so results may not apply broadly. Fentanyl carries risks like breathing problems in newborns.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
IWK Health
Halifax, Nova Scotia, Canada
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