PAIN MANAGEMENT

This study is testing if adding a low dose of the anesthetic drug ketamine during surgery can help reduce shoulder pain, a common side effect after laparoscopic gastric sleeve surgery. Researchers will compare pain levels in about 50 patients who receive ketamine as part of their…

This study compares two pain management approaches for adults recovering from rotator cuff repair surgery. Researchers want to see if a combination of non-narcotic medications works as well as or better than the current standard, which relies more on opioid painkillers. The goal …

This study aims to find out which of two common nerve-blocking techniques is better at managing pain after gallbladder removal surgery. Sixty adult patients will be randomly assigned to receive one of the two ultrasound-guided injections before their operation. Researchers will t…

This study aims to find out which non-surgical treatment works better for a painful wrist condition called De Quervain's tenosynovitis. It will compare wearing a supportive wrist splint to doing a set of hand exercises at home. Forty adults with recent wrist pain will be randomly…

This study is testing whether a special heat wrap worn on the knee for 7 days can safely reduce pain for people with moderate osteoarthritis. About 80 adults with knee pain will use the wrap for 8 hours a day. Researchers will measure changes in pain levels and how satisfied peop…

This study compares two different approaches to managing pain during early labor. Researchers are testing whether a combination of two common pain medications (tramadol and paracetamol given through an IV) works better and causes fewer side effects than the standard pethidine inj…

This study is testing if adding a short course of a steroid pill (methylprednisolone) to standard pain medication can better control pain and reduce the need for opioid pills after ACL knee surgery. About 90 patients aged 13-50 having ACL repair will be randomly assigned to get e…

This study aims to find out which of two common steroid injections is better at reducing pain and swelling after surgery for a broken jaw. It will involve 72 adults with a specific type of jaw fracture. Researchers will directly compare the drugs dexamethasone and methylprednisol…

This study is testing if playing music during a colonoscopy can help reduce the pain and discomfort many patients feel. Over 1,000 people will be randomly assigned to have their procedure with or without background music. The goal is to see if this simple, low-cost method can mak…

This study is testing two minimally invasive procedures to control severe chest pain in adults who have suffered combat-related chest injuries in Ukraine. It aims to see if using extreme cold (cryoablation) or controlled heat (radiofrequency ablation) on specific nerves is better…

This study is testing a new, long-acting numbing medicine to better manage pain after hemorrhoid surgery. Researchers will compare this new medicine against a standard one by measuring how much pain patients feel and how much extra pain medication they need after their operation.…

This study compares two different pain control methods for patients having robotic kidney removal surgery. Researchers want to see if a new combination of four common pain medications (called R.E.C.K.) works as well as the more expensive standard medication (Exparel) at reducing …

This study compares two different nerve block techniques to see which one better helps patients with hip fractures get into position for spinal anesthesia. Researchers want to know if a newer block method works better than a more established one at reducing pain during this criti…

This study is testing a new pain management strategy for people having minimally invasive colon surgery. Researchers will compare a combination of two targeted nerve blocks against standard pain medication to see if it better reduces pain and the need for opioid drugs in the firs…

This study is comparing two different ways to perform a nerve block for patients having forearm or hand surgery. The goal is to see which method works better for controlling pain during and after the operation, specifically for patients with obesity. Researchers will measure how …

This study is testing if a new, long-acting numbing medicine (liposomal bupivacaine) works better than the standard numbing medicine when injected into the surgical cuts after minimally invasive lung surgery. Researchers want to see if it reduces pain and the need for strong pain…

This study aims to find the best way to manage pain for children aged 1 to 8 years after a common hernia repair surgery. Researchers will compare two different nerve-blocking techniques given during the operation to see which provides more effective and longer-lasting pain relief…

This study is testing if a numbing injection (nerve block) given during facial fracture surgery can reduce the need for strong opioid painkillers right after the operation. It will involve 70 adults having surgery for a broken jaw or cheekbone. Participants will be randomly assig…

This study is testing whether psilocybin, the active compound in 'magic mushrooms,' combined with therapy can help reduce severe pain in people with advanced cancer when standard opioid painkillers are not effective enough. About 15 participants will receive one dose of psilocybi…

This study is testing a new 'smart' pain pump that adjusts medication based on a patient's needs, comparing it to a standard pump. It aims to see if the smart pump can use less opioid pain medication while providing better pain relief and fewer side effects for adults recovering …

This study is testing if a targeted numbing injection, given during surgery, can better control pain and reduce the need for strong opioid painkillers after kidney donation. Fifty people donating a kidney will be randomly assigned to receive either the standard anesthesia or the …

This study is testing whether giving a non-opioid pain medication called nefopam continuously after a major pancreatic surgery can help reduce the need for strong opioid painkillers and improve pain control. Researchers will compare this approach to two other standard pain manage…

This study aims to find which of two nerve-blocking techniques provides better pain relief and patient satisfaction after hernia repair surgery. Researchers will compare the M-TAPA block and the TAP block in 60 adults having elective hernia surgery. They will measure patients' pa…

This small study is testing whether a supervised exercise program can help reduce pain sensitivity in breast cancer survivors who have persistent pain after treatment. Researchers will work with 10 women who have completed their cancer treatment at least 6 months ago but still ex…

This study aims to see if giving a calming sedative before a spinal anesthetic, and using an ultrasound machine to guide the needle, can reduce back pain after surgery. It will involve 180 adults having planned lower body surgery. Researchers will compare three different approach…

This study is testing two different 'smart' pain pump methods to see which one works better for managing pain after surgery. It will involve 450 adults having various planned surgeries. The goal is to find a method that uses less opioid medication while still controlling pain eff…

This study is testing if a specific nerve block, given before surgery, can better control pain in young children having heart surgery. Researchers will use a special monitor to measure pain levels during the operation in 60 children aged 6 months to 7 years. The goal is to see if…

This study in Ukraine aims to find out which of two minimally invasive procedures works better for reducing severe nerve pain caused by combat injuries. Fifty adult patients with this type of pain will be randomly assigned to receive either a 'freezing' (cryoablation) or a 'heati…

This study is comparing two non-surgical treatments for mild to moderate carpal tunnel syndrome (CTS) against standard home exercises. Researchers want to see if adding either kinesiotaping (a special elastic tape) or peloidotherapy (therapeutic mud packs) to a home exercise prog…

This study is testing whether a combination of pain education and a tailored exercise program can help reduce pain, improve quality of life, and change negative thought patterns in women with endometriosis. Researchers at the University of Seville are enrolling 32 adult women dia…

This study is testing if a simple breathing exercise can work as well as a numbing shot to reduce pain during joint injections for conditions like arthritis. Researchers will compare pain levels in two groups: one gets a standard numbing shot, and the other learns a special breat…

This study is testing if adding a low dose of the drug ketamine to standard opioid pain medicine works better for children and young adults with sickle cell disease during a severe pain crisis. Researchers will compare pain levels, opioid use, and hospital stays between two group…

This study is testing if a common anti-inflammatory drug (ketorolac) can be used at lower doses to safely reduce pain in ICU patients, with the goal of decreasing their need for strong opiate painkillers. It's a small pilot study with 30 participants to see if a larger trial is p…

This study aims to find out which type of anesthesia provides better pain relief and satisfaction for Parkinson's patients having the battery in their deep brain stimulator replaced. Researchers will compare two common methods: putting the patient fully to sleep (general anesthes…

This study is testing a new, long-acting pain relief injection for patients having a type of minimally invasive chest surgery. Researchers want to see if a special nerve block using a slow-release numbing medicine can better control pain after surgery compared to standard methods…

This study compares two different nerve-blocking techniques to manage pain after heart surgery through the breastbone. Researchers will test which method provides better pain relief and recovery for 50 patients undergoing this type of surgery. The goal is to improve comfort and r…

This study aims to find the best way to manage pain after a common type of minimally invasive lung surgery (VATS). Researchers are comparing two nerve-blocking techniques to see which one leads to a better overall recovery experience for patients in the first 24 hours after surge…

This study is testing whether teaching patients simple breathing exercises after transplant surgery can help reduce their pain and improve their recovery. Researchers will compare 60 patients who do the breathing exercises with those who receive standard hospital care. The goal i…

This study is testing a new mobile phone app designed to help cancer survivors manage pain and other symptoms after treatment. The app provides educational messages, tips for talking with doctors, and tools for tracking how you feel. Researchers want to see if the app is easy to …

This study is testing whether a supervised aerobic exercise program, combined with education about pain, can help women with migraines. It will compare this approach to general recommendations for home-based physical activity. The goal is to see if exercise can reduce migraine-re…

This study is testing whether a short, audio-guided mindfulness practice can help reduce pain for patients waiting in an orthopedic clinic. Researchers will compare the mindfulness audio to standard injury management information. The goal is to see if this brief, accessible inter…

This study is testing a new, FDA-approved non-opioid pain medication called Suzetrigine (Journavx™) for people having hip replacement surgery. The goal is to see if it can effectively manage post-surgery pain and reduce the need for traditional opioid painkillers, which can have …

This study is testing whether taking melatonin, a natural hormone, before a planned C-section can help control pain after the surgery. Researchers will give 60 women different doses of melatonin to see which works best to reduce pain and lower the need for strong opioid painkille…

This study aims to understand how a mild electrical stimulation, similar to a TENS unit, applied to specific acupoints on the hand affects the brain's processing of pain. Researchers will measure brain wave responses to a mild, brief pain stimulus in 35 healthy adult volunteers b…

This study aims to understand how common chronic pain and a heightened pain sensitivity called 'central sensitization' are in autistic adults. Researchers will recruit 100 adults with autism (without an intellectual disability) to complete questionnaires about their pain, sensory…

This study aims to understand how a pain medication called metamizole (Optalgin) affects the blood levels of certain blood thinners (DOACs) in cancer patients. Researchers will measure blood thinner concentrations in 30 adult cancer patients who take both medications. The goal is…

This study aims to understand the patterns of pain and recovery in the weeks after a limb amputation. Researchers will look back at the medical records of 150 patients to see how quickly they regained function and managed pain. The goal is to identify which factors, like age or t…

This study aims to understand what sensations can be created using spinal cord stimulation and how changing the stimulation settings affects these feelings. Researchers are enrolling 10 adults who are already getting spinal cord implants for chronic pain treatment. The goal is to…