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Magic mushroom compound tested for cancer pain that opioids Can't touch

NCT ID NCT06001749

Recruiting now Symptom relief Sponsor: Yvan Beaussant, MD, MSci Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 06, 2026 · Updated 2 times

Summary

This study tests whether psilocybin, the active ingredient in magic mushrooms, can help relieve severe pain in people with advanced cancer when opioids don't work. Fifteen participants will receive psilocybin capsules along with therapy sessions. The goal is to see if this approach is safe, acceptable, and worth studying further.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
psilocybin (a psychedelic compound)
What this could lead to
If it works, this could offer a new way to manage severe pain in advanced cancer patients who don't respond to opioids.
What could go wrong
This is a very small early-phase trial with only 15 people, so results may not apply broadly. Psilocybin can cause intense psychological effects and is not yet proven for pain relief.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

agnosia cancer neoplasm opiate dependence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED CANCER ADVANCED CANCERS OPIOID-RELATED DISORDERS PAIN MANAGEMENT PAIN MANAGEMENT AND CARE

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

  • Contact

    Email: •••••@•••••

Locations

  • Dana-Farber Cancer Institute

    RECRUITING

    Boston, Massachusetts, 02215, United States

    Contact Email: •••••@•••••

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