New pain drug could cut opioid use after hip surgery

NCT ID NCT07226700

Recruiting now Symptom relief Sponsor: Hospital for Special Surgery, New York Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 31, 2026 · Updated 2 times

Summary

This study tests suzetrigine, a new FDA-approved non-opioid pain medication, in 210 adults undergoing total hip replacement. Participants receive either suzetrigine or a placebo for seven days, starting before surgery. The goal is to see if suzetrigine reduces the amount of opioids needed in the first 48 hours after surgery, potentially improving recovery and lowering risks like addiction.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: suzetrigine
What this could lead to: If it works, this could offer a safer, non-addictive painkiller for hip replacement recovery, reducing reliance on opioids.
What could go wrong: This is a Phase 3 trial, but it's still early to know if suzetrigine works better than placebo for this specific surgery. The drug may not significantly reduce opioid use or pain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

agnosia Pain substance withdrawal syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

JOURNAVX MULTIMODAL ANALGESIA NAV 1.8 OPIOID CESSATION OPIOID CONSUMPTION, POSTOPERATIVE PAIN PAIN MANAGEMENT RANDOMIZED CONTROLLED STUDY RANDOMIZED CONTROLLED TRIAL RANDOMIZED CONTROLLED TRIALS SUZETRIGINE TOTAL HIP ARTHROPLASTY (THA) TOTAL HIP REPLACEMENT TOTAL HIP REPLACEMENT ARTHROPLASTY TOTAL HIP REPLACEMENT SURGERY TOTAL HIP REPLACEMENTS

Contacts and locations

Locations

Hospital for Special Surgery
RECRUITING

New York, New York, 10021, United States

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