Hospital For Special Surgery, New York

This study tests whether applying tranexamic acid directly into the surgical wound, in addition to giving it through an IV, can reduce blood loss and the need for blood transfusions in adults undergoing long-segment spine surgery for scoliosis or degenerative joint disease. About…

This study tests whether adding two immune-suppressing drugs (belimumab and rituximab) to standard therapy can improve skin fibrosis in people with early, severe diffuse scleroderma. About 30 adults will receive either the drug combination or placebo injections, while all continu…

This early-phase study tests whether a new drug, ONTO1, is safe and tolerable for people with lupus nephritis or systemic lupus erythematosus. About 61 participants will receive ONTO1 alongside standard lupus treatments like mycophenolate mofetil. The goal is to find the highest …

This study provides a special finger joint implant for people with arthritis who have had a previous implant fail. It is not a research study but a way to access this device under FDA rules. Participants must need a revision surgery and be able to put heavy loads on their hands. …

This study tests whether a platelet-rich plasma (PRP) injection given soon after an ACL tear can reduce inflammation and improve knee function, with the goal of lowering the risk of post-traumatic osteoarthritis later. About 56 people with a recent ACL injury will receive either …

This study tests whether a concentrated bone marrow injection (cBMA) can reduce pain and inflammation in people who develop knee arthritis after a second ACL reconstruction surgery. About 40 adults aged 18 to 55 will receive either cBMA with surgery or surgery alone. Researchers …

This study tests a new back brace designed to prevent a condition called proximal junctional kyphosis (PJK), where the spine curves abnormally above the surgical area after adult spinal deformity surgery. Researchers will enroll 84 adults aged 30-75 who are having their first spi…

This study looks at whether bisphosphonates, drugs used to strengthen bones, can help hearing loss in people with Osteogenesis Imperfecta (OI) type I. About 100 adults and children with OI will either receive the drug or be observed for up to 5 years. The goal is to see if the tr…

This study tests if drinking a special carbohydrate drink before knee or hip replacement surgery helps patients leave the hospital sooner. About 312 adults having same-day joint replacement will be randomly assigned to get the drink or a placebo. The goal is to see if the drink r…

This study tests whether a single shot of platelet-rich plasma (PRP) can reduce pain and improve function in people with shoulder osteoarthritis. Researchers will compare low-dose PRP, high-dose PRP, and a saline placebo in 135 adults aged 18-100. The goal is to see if PRP offers…

This study tests if placing a steroid directly on the spine during back surgery helps reduce pain and the need for opioid painkillers afterward. About 150 adults having a 1-2 level lumbar laminectomy will be randomly assigned to receive the steroid or not. Researchers will track …

This study looks at whether wearing a knee brace for 10 days after revision knee replacement surgery helps patients regain better knee movement after 3 months. About 170 adults having revision knee replacement for reasons like loosening or instability will be split into two group…

This study tests a new pain medicine called suzetrigine in 210 adults having hip replacement surgery. Half will get the drug and half a placebo for 7 days, starting before surgery. The main goal is to see if it lowers the amount of opioids needed in the first 48 hours after surge…

This study is testing a standardized physical therapy program for people aged 18 to 60 with non-arthritic hip and groin pain. The goal is to see if this approach can improve quality of life and reduce pain. Participants will follow a specific exercise plan and be monitored for re…

This study tests whether a special nerve block (erector spinae plane block) can lower the amount of opioid pain medication patients need after minimally invasive lower back surgery. About 48 adults scheduled for this surgery will be randomly assigned to receive the block or not. …

This study tests a powered knee brace called Agilik in 10 children with cerebral palsy who walk with a crouched gait. The brace helps straighten the knees and reduce effort while walking. Researchers will compare walking with the brace to walking without it to see if it improves …

This study compares two nerve block methods (AFCN block vs. adductor canal block) for pain control in children aged 8-18 having ACL or MPFL knee surgery. Researchers will measure pain levels, opioid use, and muscle strength recovery. The goal is to find which block provides bette…

This study tests a new device that only gives out opioid pain pills at set times after spine surgery. Half of the 30 participants will use the device and a phone app, while the other half will use a standard pill bottle and app. The goal is to see if the device helps people take …

This study tests if a continuous pain-relief catheter placed near the knee works better than a single injection for controlling pain after total knee replacement. About 64 adults will be randomly assigned to one of two groups. The goal is to see which method reduces the need for …

This study looks at whether injecting bone marrow fluid into the knee during routine arthroscopic surgery can improve pain and function. Fifty adults with cartilage or meniscus injuries will be randomly assigned to get either a bone marrow injection or a saltwater injection durin…

This study compares two pain-relief methods for total knee replacement: a single injection versus a continuous catheter that delivers numbing medicine. About 94 adults having knee surgery will be randomly assigned to one of the two groups. The goal is to see which approach reduce…

This study looks at 20 adults with a pinched nerve in the neck (cervical radiculopathy) to see if combining advanced MRI scans with nerve tests can improve diagnosis and predict who will get better with treatment. Participants will undergo imaging and electrical studies, and thei…

This study follows 850 people aged 10–35 who are having surgery for a dislocating kneecap. Researchers want to learn what factors lead to the kneecap dislocating again after surgery. Participants will answer surveys about their knee function and activity level one and two years a…

This study looks at whether people who have surgery for broken bones can shower earlier than usual without raising their risk of infection. Half of the 56 participants will be told to shower normally with the wound uncovered a few days after surgery, while the other half will fol…

This study is creating a registry of 300 adults with scleroderma to collect medical information and samples over time. The goal is to help scientists learn more about the disease, its genetics, and how it progresses. While this registry does not test a new treatment, it aims to l…

This study follows 432 golfers who have hip, knee, or shoulder replacement surgery to see when and how they return to golf. Participants are active golfers who want to get back to the sport. Researchers will check in at 6 weeks, 3 months, 6 months, and 1 year after surgery to tra…

This study tests a new device called BrightPoint that uses light to help doctors confirm they have placed an epidural needle in the right spot during lumbar spine surgery. About 36 adults having spine surgery will take part. Doctors will use the device alongside the standard meth…

This study follows 250 adults who are having shoulder replacement surgery at Hospital for Special Surgery. Researchers will collect information from patients and surgeons over 1, 2, 5, and 10 years to understand how well the replacements work and what affects long-term success. N…

This study looks at how a drug called abatacept (Orencia) changes immune cells in people with rheumatoid arthritis. Researchers will compare patients starting abatacept, those on other treatments, and healthy volunteers. The goal is to understand why joints swell and hurt, and to…

This study tests whether using artificial intelligence to simplify patient education materials helps parents understand pediatric orthopaedic conditions better. Researchers will compare original handouts with AI-simplified versions. About 80 parents or guardians of children treat…

This study is creating a registry of 100 people with undifferentiated connective tissue disease (UCTD) to better understand how the condition changes over time. Participants will complete questionnaires about their quality of life, fatigue, and mood, and doctors will track their …

This study uses a special thermal camera to take pictures of the feet of people with Complex Regional Pain Syndrome (CRPS) before and after they receive spinal cord stimulation. The goal is to see if the camera can detect changes in blood flow and nerve activity that match improv…

This study follows 700 pregnant women with lupus or antiphospholipid syndrome to see if certain proteins in the blood can predict serious pregnancy complications like fetal death, preterm birth, or low birth weight. Participants are enrolled early in pregnancy and monitored throu…