Hospital For Special Surgery, New York

This program provides a special finger joint implant for people with arthritis in the finger's middle joint. It is for those who have had a previous implant fail or who cannot use other implants due to heavy hand use. The goal is to relieve pain and improve function. This is not …

This study tests whether bisphosphonates, drugs commonly used to strengthen bones, can also treat hearing loss in people with Osteogenesis Imperfecta (OI) type I. Researchers will enroll 100 adults and children with OI, giving some the drug and comparing their hearing over time. …

This study tests whether applying tranexamic acid directly into the surgical wound, in addition to giving it through an IV, can reduce bleeding and the need for blood transfusions in adults having extensive spine surgery. About 100 adults aged 18 to 80 with spinal deformity will …

This study looks at whether adding a bone marrow injection to standard knee surgery can improve pain and function for people with cartilage or meniscus injuries. Fifty adults aged 18 to 64 will be randomly assigned to get either the bone marrow injection or a placebo saltwater in…

This study tests whether adding two immune-targeting drugs (belimumab and rituximab) to standard mycophenolate can improve skin fibrosis in people with early diffuse systemic sclerosis. Thirty adults with recent-onset disease will receive either the combo or placebo injections fo…

This study tests whether a platelet-rich plasma (PRP) injection, given soon after an ACL knee injury, can reduce inflammation and improve knee function. About 56 people with a recent ACL tear will receive either PRP or a placebo. The goal is to see if this treatment can lower the…

This study tests whether a concentrated bone marrow injection (cBMA) given during repeat ACL surgery can reduce knee pain and signs of arthritis. About 40 adults aged 18-55 who need a second ACL repair will receive either cBMA plus surgery or surgery alone. Researchers will track…

This early-phase study tests whether a new drug called ONT01 is safe for people with lupus nephritis or systemic lupus erythematosus (SLE). About 61 participants will receive ONT01 alongside their usual lupus medications. The goal is to find the highest safe dose and see if it im…

This study tests whether a special type of MRI called MR neurography can better detect pinched nerves in the neck (cervical radiculopathy) compared to standard tests. Researchers will enroll 20 adults with recent symptoms and compare imaging results with nerve tests and physical …

This study tests a new back brace designed to prevent a common complication called proximal junctional kyphosis (PJK) after spinal deformity surgery. Researchers will enroll 84 adults aged 30-75 who are having their first spinal fusion surgery. Participants will wear the brace af…

This study tests suzetrigine, a new FDA-approved non-opioid pain medication, in 210 adults undergoing total hip replacement. Participants receive either suzetrigine or a placebo for seven days, starting before surgery. The goal is to see if suzetrigine reduces the amount of opioi…

This study tests whether placing a steroid (Depo-Medrol) directly on the spine during back surgery can lower pain and the need for opioid painkillers afterward. About 150 adults having one- or two-level lumbar decompression will be randomly assigned to get the steroid or a placeb…

This study compares two ways to manage pain after total knee replacement: a single-shot nerve block versus a continuous nerve block using a small catheter. About 94 adults having knee surgery will be randomly assigned to one method. The goal is to see which approach reduces opioi…

This study looks at whether wearing a knee brace that keeps the knee straight for 10 days after revision total knee replacement helps improve knee bending and straightening 3 months later. About 170 people having revision surgery for reasons like loosening or wear will be split i…

This study is testing a standardized physical therapy program for people aged 18 to 60 who have hip or groin pain not caused by arthritis. The goal is to see if this program can improve quality of life and reduce pain. Participants will follow a set therapy plan and track their p…

This study tests whether drinking a carbohydrate-rich beverage three hours before joint replacement surgery can shorten hospital stays and improve same-day discharge rates. Researchers will enroll 312 adults undergoing hip or knee replacement. The goal is to see if this simple st…

This study compares two ways to manage pain after total knee replacement: a continuous nerve catheter that delivers numbing medicine for days versus a single nerve block. Sixty-four adults scheduled for knee surgery will be randomly assigned to one of the two methods. Researchers…

This pilot study tests a new device that only releases opioid pills at set times after spine surgery, aiming to reduce misuse and side effects. Half of the 30 participants will use the device and an app, while the other half get a standard pill bottle and app. Researchers will tr…

This study compares two types of nerve blocks—anterior femoral cutaneous nerve block and adductor canal block—for children aged 8–18 having ACL or MPFL knee surgery. Sixty participants will be randomly assigned to receive one of the blocks along with standard pain care. Researche…

This study tests whether a specific nerve block (erector spinae plane block) can lower the amount of strong pain medicine patients need after minimally invasive lower back surgery. About 48 adults having a one-level lumbar fusion will be randomly assigned to receive the block or …

This study tests whether a single injection of platelet-rich plasma (PRP) — made from your own blood — can reduce pain and improve shoulder function in people with shoulder osteoarthritis. Researchers will compare low-dose PRP, high-dose PRP, and a plain saline injection in 135 a…

This observational study is following 700 pregnant women with lupus or antiphospholipid syndrome across nine medical centers. Researchers are looking at specific proteins in the blood to see if they can predict serious pregnancy complications like fetal death, preterm delivery, o…

This study looks at whether using artificial intelligence to simplify medical handouts helps parents understand their child's bone condition better. About 80 parents of children treated at a special surgery hospital will read either the original or an AI-simplified version and th…

This study looks at whether it's safe and satisfying to shower early after orthopedic fracture surgery, compared to waiting longer. About 56 adults with arm or leg fractures will be randomly assigned to bathe early or follow the traditional delayed approach. The goal is to see wh…

This study follows 850 people aged 10–35 who are having surgery for a kneecap that keeps dislocating. Researchers want to find out what factors increase the risk of the kneecap dislocating again after surgery. Participants will fill out surveys about their knee function and activ…

This study follows 250 people who have had shoulder replacement surgery at Hospital for Special Surgery. Researchers will collect patient-reported outcomes, surgeon data, and demographics at 1, 2, 5, and 10 years after surgery. The goal is to understand what predicts good results…

This study is for people with rheumatoid arthritis who are starting a drug called abatacept (Orencia). Researchers want to see how this drug changes certain immune cells (T and B cells) in the blood over 6 months. They will compare these changes to those in people taking other ar…

This registry follows 100 people with undifferentiated connective tissue disease (UCTD), a condition with symptoms like joint pain, rash, and fatigue that doesn't fit a specific diagnosis. Researchers will track changes in quality of life, fatigue, depression, and disease feature…

This study follows 432 golfers who have hip, knee, or shoulder replacement surgery to see when and how they return to golf. Participants are active golfers who want to play again after surgery. The goal is to learn about the recovery process, not to test a new treatment.

This study tests a new device called BrightPoint that uses light to help doctors confirm they have placed an epidural needle in the right spot during lumbar spine surgery. About 36 adults having surgery will take part. Doctors will use the device along with the standard method an…

This study uses a special thermal camera to take pictures of the feet of people with complex regional pain syndrome (CRPS) before and after they receive spinal cord stimulation. The goal is to see if the stimulation changes blood flow and temperature in the painful limb. Research…

This registry is collecting medical information and biological samples from 300 adults with scleroderma at a single hospital. The goal is to better understand the disease's features, genetics, and progression. While this study does not test any treatment, the data gathered could …