Hospital For Special Surgery, New York

This study tests whether applying tranexamic acid directly into the surgical wound, in addition to giving it through an IV, can reduce bleeding and the need for blood transfusions in adults undergoing long spine fusion surgery. About 100 adults aged 18 to 80 with spinal deformity…

This early-phase study tests whether a new drug, ONTO1, is safe and tolerable for people with lupus nephritis or systemic lupus erythematosus (SLE). Researchers will give ONTO1 alongside standard lupus treatments to 61 adults and look for side effects and signs of symptom improve…

This program offers a special finger joint implant to people with arthritis or a failed prior implant who need strong hands for daily activities. It is not a research study but a humanitarian-use device approved by the FDA. Participants must have a failed previous implant or be u…

This study tests whether adding two immune-targeting drugs (belimumab and rituximab) to standard therapy can improve skin hardening in people with early diffuse systemic sclerosis. About 30 adults will receive either the drug combination or placebo, plus their usual medication, f…

This study tests whether a platelet-rich plasma (PRP) injection given soon after an ACL tear can reduce inflammation and improve knee function, with the goal of lowering the risk of post-traumatic osteoarthritis later. About 56 people with a recent ACL injury will receive either …

This study tests whether a concentrated bone marrow injection (cBMA) can reduce pain and inflammation in people who develop knee arthritis after a second ACL reconstruction surgery. About 40 adults aged 18 to 55 will receive either cBMA with surgery or surgery alone. Researchers …

This study tests a new back brace designed to prevent a condition called proximal junctional kyphosis (PJK), where the spine curves abnormally above the surgical area after adult spinal deformity surgery. Researchers will enroll 84 adults aged 30-75 who are having their first spi…

This study compares two nerve block methods (AFCN block vs. adductor canal block) for pain control in children aged 8-18 having ACL or MPFL knee surgery. Researchers will measure pain levels, opioid use, and muscle strength recovery. The goal is to find which block provides bette…

This study looks at whether wearing a knee brace for 10 days after revision knee replacement surgery helps improve knee movement 3 months later. About 170 adults having revision knee replacement for reasons like loosening or instability will be assigned to either wear a brace and…

This study tests if a continuous pain-relief catheter placed near the knee works better than a single injection for controlling pain after total knee replacement. About 64 adults will be randomly assigned to one of two groups. The goal is to see which method reduces the need for …

This study tests a new pain medicine called suzetrigine in 210 adults having hip replacement surgery. Half will get the drug and half a placebo for seven days, starting before surgery. The goal is to see if it lowers the amount of opioids needed for pain in the first 48 hours aft…

This study compares single injections of low-dose platelet-rich plasma (PRP), high-dose PRP, or saline in 135 adults with shoulder osteoarthritis. The goal is to see if PRP reduces pain and improves shoulder function better than a placebo (saline). Participants must have moderate…

This study tests whether a special nerve block (erector spinae plane block) can lower the amount of strong pain medicine patients need after minimally invasive lower back surgery. About 48 adults having a specific type of spinal fusion will be randomly assigned to get the block o…

This study tests whether drinking a special carbohydrate drink before surgery can help people leave the hospital sooner after hip or knee replacement. Researchers will track how long participants stay in the hospital and how well they recover. The study involves 312 adults schedu…

This study tests a powered knee brace called Agilik in 10 children with cerebral palsy who walk with a crouched gait. The brace helps straighten the knees and reduce effort while walking. Researchers will compare walking with the brace to walking without it to see if it improves …

This study tests a new device that only releases opioid pain pills after a patient enters their pain level into a smartphone app. Half of the 30 spine surgery patients will use the device, while the other half get a standard pill bottle. The goal is to see if the device helps pat…

This study tests if applying a steroid during back surgery can lower pain and the need for strong painkillers. About 150 adults having a 1-2 level lumbar laminectomy will be randomly assigned to receive the steroid or not. Researchers will track opioid use, hospital stay length, …

This study looks at whether injecting bone marrow fluid into the knee during routine arthroscopic surgery can improve pain and function. Fifty adults with cartilage or meniscus injuries will be randomly assigned to get either a bone marrow injection or a saltwater injection durin…

This study is testing a standardized physical therapy program for people aged 18 to 60 who have hip or groin pain without arthritis. The goal is to see if this program improves quality of life and reduces pain. About 70 participants will be enrolled and followed for several weeks…

This study compares two pain-relief methods for total knee replacement: a single injection versus a continuous catheter that delivers numbing medicine. About 94 adults having knee surgery will be randomly assigned to one of the two groups. The goal is to see which approach reduce…

This study tests whether bisphosphonates, drugs often used for bone health, can improve hearing loss in people with Osteogenesis Imperfecta (OI), also known as brittle bone disease. The researchers will enroll 100 adults and children with OI, some receiving the drug and others no…

This study uses a special thermal camera to take pictures of the feet of people with Complex Regional Pain Syndrome (CRPS) before and after they receive spinal cord stimulation. The goal is to see if the camera can detect changes in blood flow and nerve activity that match improv…

This study looks at whether using artificial intelligence to simplify written medical information helps parents understand their child's bone condition better. Researchers will give 80 parents either the original or an AI-simplified version of a patient handout, then test their u…

This study follows 432 golfers who have hip, knee, or shoulder replacement surgery to see when and how they return to golf. Participants are active golfers who want to play again after surgery. Researchers will check in at 6 weeks, 3 months, 6 months, and 1 year after surgery to …

This study looks at whether it's safe and satisfying to shower early after orthopedic surgery for broken bones. Half of the 56 participants will bathe normally without covering their wound, while the other half will follow the traditional delayed approach with covered wounds. The…

This study is creating a registry of 100 people with undifferentiated connective tissue disease (UCTD) to better understand how the condition changes over time. Participants will complete questionnaires about their quality of life, fatigue, and mood, and doctors will track their …

This study follows 250 people who are getting a shoulder replacement at Hospital for Special Surgery. Researchers will track their recovery and quality of life for up to 10 years using questionnaires and surgery data. The goal is to learn what affects long-term success and why so…

This study follows 850 people aged 10–35 who are having surgery to fix a kneecap that keeps popping out of place. Researchers want to find out why the problem sometimes comes back after surgery and how well patients recover. Participants will fill out surveys about their knee fun…

This study looks at how a drug called abatacept (Orencia) affects immune cells in people with rheumatoid arthritis. Researchers will compare patients starting abatacept, those on other treatments, and healthy volunteers. The goal is to understand why joints swell and hurt, and fi…

This study follows 700 pregnant women with lupus or antiphospholipid syndrome to see if certain proteins in the blood can predict serious pregnancy complications like fetal death, preterm birth, or low birth weight. Participants are enrolled early in pregnancy and monitored throu…

This study tests a new device called BrightPoint that uses light to help doctors confirm they have placed an epidural needle in the right spot during lumbar spine surgery. About 36 adults having this type of procedure will take part. The device is not meant to replace the current…

This study is creating a registry of 300 adults with scleroderma to collect medical information and samples over time. The goal is to learn more about the disease's features, genetics, and biology, which could lead to future treatments. Participants will provide skin scores and c…

This study looks at 20 people with a pinched nerve in the neck (cervical radiculopathy). Researchers will use special MRI scans and nerve tests to see if they can better diagnose the problem and predict how well treatment works. The goal is to improve understanding, not to test a…