Knee replacement patients may use fewer opioids with new pain block

NCT ID NCT03747146

Recruiting now Symptom relief Sponsor: Hospital for Special Surgery, New York Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares two ways to manage pain after total knee replacement: a single-shot nerve block versus a continuous nerve block using a small catheter. About 94 adults having knee surgery will be randomly assigned to one method. The goal is to see which approach reduces opioid painkiller use and improves recovery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: continuous adductor canal catheter with saline
What this could lead to: If successful, this could show that a continuous nerve block provides better pain relief and reduces opioid use after knee replacement surgery.
What could go wrong: This is a small, early-stage study with only 94 participants, so results may not apply to everyone. The intervention is a device and saline, not a new drug, so the impact is limited to pain management.

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Conditions

The condition(s) this trial relates to.

osteoarthritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANESTHESIA

Contacts and locations

Locations

Hospital for Special Surgery
RECRUITING

New York, New York, 10023, United States

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