Hospital For Special Surgery, New York

This early-phase study tests a new treatment called NKX019 for people with lupus, an autoimmune disease. NKX019 uses specially engineered immune cells to target and calm overactive B cells. The main goal is to check safety in about 6 participants, while also looking for signs tha…

This study looks at whether adding the drug abaloparatide (Tymlos) to the standard treatment denosumab (Prolia) can improve bone density more than denosumab alone in postmenopausal women with osteoporosis. Seventy women who have already been on denosumab will either continue with…

This study looks at a natural protein called Natural Matrix Protein (NMP) used as a bone graft substitute during lumbar spinal fusion surgery. Researchers will review the medical records of about 100 adults who had this surgery to see how well their bones fused and if there were …

This phase 2 trial tests whether a patient's own fat-derived cells (stromal vascular fraction) can improve healing after surgical repair of a chronic rotator cuff tear. The study enrolls 56 adults aged 45-65 with full-thickness tears who have not improved with physical therapy. T…

This phase 2 trial tests whether the bone-building drug abaloparatide (Tymlos) can improve healing after spinal fusion surgery. About 96 postmenopausal women and men aged 50+ will receive either the drug or a placebo daily for 6 months. Researchers will check bone fusion quality …

This study looks at whether surgery to repair a ligament in the knee (MPFL) is better than non-surgical care for preventing repeat kneecap dislocations in people aged 25 and younger who have dislocated their kneecap once. About 240 participants will be randomly assigned to surger…

This early-phase trial tests whether injecting special donor cells (E-CEL UVEC) into the shoulder during rotator cuff surgery is safe and might improve healing. Twenty adults aged 45-70 with full-thickness tears will receive the cells at the repair site. The main goal is to check…

This study tests whether a very low dose of naltrexone, a drug usually used for addiction, can reduce pain and other symptoms in people with Complex Regional Pain Syndrome (CRPS). Forty adults with CRPS will receive either the drug or a placebo for six months. The main goal is to…

This study looks at two ways to numb people for lower back surgery: general anesthesia (being fully asleep) plus a nerve block, or spinal anesthesia (numbing only the lower body) plus a nerve block. The goal is to see which approach helps patients recover better and feel less pai…

This study compares two types of shockwave therapy—radial and focused—to see which better reduces pain from chronic plantar fasciitis (heel pain lasting over 3 months). About 114 adults with stubborn heel pain will receive one of the two treatments. The goal is to find out if one…

This study tests whether an intravenous fat emulsion called Intralipid 20% can reverse the numbing effect of common local anesthetics like lidocaine and bupivacaine. Eighteen healthy volunteers receive small injections of these anesthetics in their thigh, followed by either Intra…

After lumbar spine surgery, many people stay inactive due to fear of pain or injury. This study tests a program that combines education, walking goals, and activity trackers to help 260 participants increase their daily walking. The goal is to see if this approach can reduce disa…

This study tests whether the steroid hydrocortisone can improve knee movement after total knee replacement. About 132 patients, some with naturally stiff knees, will receive either the drug or a placebo right after surgery. Researchers will measure how well the knee bends and str…

This early-stage trial tests the drug dalfampridine (Ampyra), already used for multiple sclerosis, in 35 adults with primary lateral sclerosis or upper motor neuron ALS. The main goal is to see if it safely improves walking speed, measured by a timed 25-foot walk. Researchers wil…

This study follows 3,000 people who had hip replacement surgery at Hospital for Special Surgery. Researchers want to learn how patients do over many years, including pain, mobility, and quality of life. Participants simply fill out questionnaires; no extra treatments or tests are…

This study looks back at the records of 1,000 adults who had foot or ankle surgery at a major orthopedic center. The goal is to understand what causes some patients to stay longer in the recovery room before going home. Researchers will measure how much time is needed for dischar…

This study aims to validate a self-report questionnaire that people with Complex Regional Pain Syndrome (CRPS) can fill out at home. Researchers will compare the self-report results with in-person clinical exams to see if the questionnaire accurately measures symptom severity and…

This study aimed to see if telling surgery patients about their high blood pressure would lead them to get a formal diagnosis. Researchers planned to call 108 patients with elevated readings and follow up six months later. However, the study was withdrawn before enrolling anyone,…

This study looks at whether patients and their surgeons have the same expectations before lumbar spine surgery. Researchers will compare survey answers from about 437 patient-surgeon pairs. The goal is to find any differences in what each side hopes the surgery will achieve, whic…

This study follows 3,000 people who had knee replacement surgery at a single hospital. Researchers collect data from questionnaires and medical records to see how patients do over many years. The goal is to learn what affects long-term success, satisfaction, and how long differen…