Could a multiple sclerosis drug help people with a rare nerve disease walk faster?

NCT ID NCT02868567

First seen Sep 30, 2025 · Last updated May 08, 2026 · Updated 31 times

Summary

This early-stage trial tests whether dalfampridine, a drug used for walking problems in multiple sclerosis, can safely improve walking speed in 35 adults with primary lateral sclerosis or a related upper motor neuron condition. Participants take the drug for 18 weeks and have their walking speed measured regularly. The goal is to see if the drug provides consistent improvement in walking.

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Contacts and locations

Locations

  • Mass General Hospital

    Boston, Massachusetts, 02114, United States

  • Shara Holzberg

    New York, New York, 10021, United States

  • University of Florida Gainsville

    Gainesville, Florida, 32607, United States

Conditions

Explore the condition pages connected to this study.