Can a targeted nerve block cut opioid use after gallbladder surgery?

NCT ID NCT07745972

Recruiting now Symptom relief Sponsor: Istinye University Source: ClinicalTrials.gov ↗

First seen Aug 04, 2026 · Last updated Aug 11, 2026 · Updated 3 times

Summary

This trial tests whether an ultrasound-guided nerve block, using the anesthetic bupivacaine, can reduce pain and the need for opioid painkillers after laparoscopic gallbladder removal. Sixty adults with a healthy weight and low surgical risk will receive either the nerve block or a placebo before surgery. Researchers will measure pain scores, opioid use, and quality of recovery during the first 24 hours after the operation.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: An ultrasound-guided nerve block using bupivacaine, a local anesthetic, injected near the ribs to numb the area.
What this could lead to: If effective, this nerve block could offer a way to manage post-surgical pain with fewer opioids, potentially reducing side effects and speeding recovery.
What could go wrong: This is a small, early-stage trial, and the block may not provide significant pain relief for everyone. There are also risks like infection, bleeding, or allergic reaction to the anesthetic.

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Conditions

The condition(s) this trial relates to.

agnosia pain agnosia Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANALGESIA PAIN MANAGEMENT PAIN, ACUTE POST-OPERATIVE

Contacts and locations

Locations

Istinye University Liv Topkapı Hospital
RECRUITING

Istanbul, 34050, Turkey (Türkiye)

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