New combo injection aims to ease abortion pain

NCT ID NCT07487246

Recruiting now Symptom relief Sponsor: Rush University Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 07, 2026 · Updated 2 times

Summary

This study tests whether a paracervical block (an injection near the cervix) containing ketorolac and lidocaine can reduce pain during placement of osmotic dilators, which are used to prepare the cervix for a second-trimester abortion. About 76 participants will be randomly assigned to receive either the new combination or standard ibuprofen. The main goal is to measure pain right after the dilators are inserted.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ketorolac and lidocaine
What this could lead to: If it works, this could offer a better pain management option for people undergoing second-trimester abortion procedures.
What could go wrong: This is a small, early-phase trial with only 76 participants, so results may not apply broadly. The treatment involves a local injection, which carries risks like bleeding or infection.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

agnosia Dilatation, Pathologic pregnancy loss, recurrent, susceptibility to, 1

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ABORTION DILATION AND EVACUATION PAIN MANAGEMENT SECOND TRIMESTER ABORTION

Contacts and locations

Locations

Rush University Medical Center
RECRUITING

Chicago, Illinois, 60612, United States

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