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Numbing ointment could ease pain after hemorrhoid surgery, reduce opioid use

NCT ID NCT07688031

Symptom relief Sponsor: Pontificia Universidad Catolica de Chile Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 07, 2026 · Last updated Jul 08, 2026 · Updated 1 time

Summary

This trial tests whether a topical ointment containing two numbing agents (lidocaine and tetracaine) can reduce pain after hemorrhoid surgery. Adults scheduled for elective hemorrhoidectomy will apply the ointment or a placebo every 12 hours for 10 days after surgery. Researchers will measure pain scores, especially after bowel movements, and track how much rescue pain medication participants need. The goal is to see if this ointment offers a safe, effective alternative to opioids for post-surgical pain.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
lidocaine 23% and tetracaine 7% topical ointment
What this could lead to
If effective, this ointment could provide a simple, non-opioid way to manage pain after hemorrhoid surgery, reducing the need for stronger painkillers.
What could go wrong
This is a small, early-phase trial, so results may not apply to everyone. The ointment may cause skin irritation or allergic reactions, and it might not work better than placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

74 people

The number who actually took part.

Started

May 2023

Finished

May 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18 years or older * Scheduled for elective hemorrhoidectomy * Recruited consecutively on the day of surgery * Able to provide written informed consent Exclusion Criteria: * Inflammatory bowel disease * Immunosuppression * Pregnancy * Chronic pain requiring ongoing analgesic treatment * Known hypersensitivity to any of the study medications * Significant cardiovascular disease * Peripheral vascular disease * Cerebrovascular disease * Hepatic disease * Seizure disorders

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Conditions

The condition(s) this trial relates to.

agnosia hemorrhoid Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hemorrhoids fourth degree Hemorrhoids second degree Hemorrhoids third degree Pain management

Contacts and locations

Locations

  • Red UC Christus Hospital

    Santiago, RM, Chile

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