Hemorrhoid

This study compares two standard treatments for bleeding internal hemorrhoids: hemorrhoidal artery embolization (HAE) and rubber band ligation (RBL). HAE uses a catheter to block blood flow to the hemorrhoid with tiny particles or coils, while RBL uses rubber bands to cut off cir…

This study tests a new, minimally invasive version of Ferguson hemorrhoidectomy for people with grade III hemorrhoids. The goal is to see if using enhanced visualization tools can reduce pain and speed recovery while keeping the surgery effective. About 50 adults who need hemorrh…

This study tests a procedure called rectal artery embolization (RAE) to treat bleeding from internal hemorrhoids. Doctors use imaging to guide tiny particles into the blood vessels feeding the hemorrhoids, blocking blood flow to reduce bleeding. The trial enrolls 20 adults with g…

This study is creating a registry to track how well a procedure called hemorrhoid artery embolization works for people with chronic bleeding internal hemorrhoids. Researchers will follow 1,200 adults for up to 3 years after the procedure, collecting data on bleeding, symptoms, an…

This study compares two minimally invasive procedures for grade II/III hemorrhoids: radiofrequency ablation (using heat) and Doppler-guided artery ligation with mucopexy (tying off blood vessels). The goal is to see if the newer heat-based method is as good as the standard one at…

This study is testing a new way to treat moderate-to-severe hemorrhoids by combining a laser procedure with a stitch technique. About 100 adults will receive the treatment and be followed for a year. The goal is to see if it reduces pain, bleeding, and tissue prolapse better than…

This study tests whether a minimally invasive procedure called Superior Rectal Artery Embolization (SRAE) works as well as rubber band ligation for controlling bleeding from hemorrhoids. SRAE blocks blood flow to the hemorrhoids using tiny particles, and is done under local anest…

This study tests a new MRI contrast agent called ferumoxytol, made from iron nanoparticles, to see if it can safely and effectively image veins in people with vein diseases. Current dyes can be risky for patients with kidney problems, but ferumoxytol may be safer and last longer …

This study will compare three surgical treatments for severe internal hemorrhoids: laser, energy therapy, and traditional surgery. About 60 adults with grade III hemorrhoids will choose their preferred treatment. The goal is to see which method provides less pain after surgery an…

This study will follow 60 adults who are having laser surgery for internal hemorrhoids. Researchers will measure pain after surgery, how long people stay in the hospital, and how satisfied patients are with the results. The goal is to understand how well this laser procedure work…

This study tests a new surgical technique called SHAPE against the standard Milligan-Morgan surgery for people with severe (third- and fourth-degree) hemorrhoids. The goal is to see if SHAPE causes less pain after surgery and leads to fewer complications. About 68 adults will tak…

This study tests whether giving ketamine during hemorrhoid surgery can reduce the amount of strong pain pills patients need afterward. About 100 adults with severe hemorrhoids will be randomly assigned to receive either ketamine or a placebo during their operation. Researchers wi…

This study tests two types of nerve blocks to control pain after hemorrhoid surgery. One group gets a pudendal block, the other a sacral ESP block, both using the same numbing medicine. Researchers will measure pain levels and how quickly patients recover. The goal is to find whi…

This study tests whether injecting botulinum toxin (Botox) into the anal muscle one week before hemorrhoid removal surgery can lower pain after the operation. About 292 adults with severe hemorrhoids will get either Botox or a placebo injection before surgery. Researchers will tr…

This study tests whether a long-acting numbing drug called liposomal bupivacaine can control pain for up to 72 hours after hemorrhoid surgery better than standard numbing medicine. About 156 adults having hemorrhoid surgery will receive either the long-acting drug or regular bupi…

This study tests a procedure called hemorrhoidal artery embolization (HAE) for people with internal hemorrhoids who have not had success with other treatments or cannot have surgery. The procedure blocks certain arteries to reduce blood flow to the hemorrhoid tissue, aiming to im…

This study looks at whether wrist-ankle acupuncture can reduce pain after perianal surgery. About 58 adults with moderate to severe pain will receive this acupuncture along with standard care. Researchers will measure pain relief and how often extra pain medicine is needed.

This observational study looks at whether a cream containing nifedipine 0.3% and lidocaine 1.5% can reduce symptoms like pain, bleeding, and prolapse in people with acute uncomplicated hemorrhoids. About 80 adults aged 18 to 75 who have already started this cream as part of their…

This study tests whether a new ultrasound-guided nerve block (sacral erector spinae plane block) can control pain after hemorrhoid removal as well as the standard saddle block. Fifty adults undergoing hemorrhoidectomy will be randomly assigned to one of the two methods. Researche…

This study compares two ointments—lignocaine and glyceryl trinitrate (GTN)—for pain relief after hemorrhoid removal. Sixty-four adults will apply one of the ointments three times daily after surgery. Researchers will measure pain scores, wound healing time, and patient satisfacti…

This pilot study tests a procedure called trans-radial superior rectal artery embolisation for treating hemorrhoids. Instead of surgery, doctors access an artery in the wrist to block blood flow to the hemorrhoid, which may reduce bleeding and pain. The study will enroll 20 adult…

This study looks at whether people with hemorrhoids are more likely to have varicose veins in their legs. Researchers will use ultrasound to check the leg veins of 400 adults—200 with hemorrhoids and 200 without. No treatments or procedures are given; the goal is simply to see if…