Could a single dose of ketamine cut opioid use after hemorrhoidectomy?
NCT ID NCT04248205
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether giving ketamine during hemorrhoid surgery can reduce the amount of strong pain pills patients need afterward. About 100 adults with severe hemorrhoids will be randomly assigned to receive either ketamine or a placebo during their operation. Researchers will count how many oxycodone pills each patient uses and measure their pain levels over two weeks.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
ketamine
What this could lead to
If it works, this could give doctors a simple way to reduce opioid use after hemorrhoid surgery, lowering the risk of addiction and side effects.
What could go wrong
This is a small, early-phase study. Ketamine may not reduce pain or pill use significantly, and it can cause side effects like hallucinations or nausea.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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University of Oklahoma Health Sciences Center
RECRUITINGOklahoma City, Oklahoma, 73104, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••