Could a single dose of ketamine cut opioid use after hemorrhoidectomy?

NCT ID NCT04248205

Recruiting now Symptom relief Sponsor: University of Oklahoma Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether giving ketamine during hemorrhoid surgery can reduce the amount of strong pain pills patients need afterward. About 100 adults with severe hemorrhoids will be randomly assigned to receive either ketamine or a placebo during their operation. Researchers will count how many oxycodone pills each patient uses and measure their pain levels over two weeks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ketamine
What this could lead to: If it works, this could give doctors a simple way to reduce opioid use after hemorrhoid surgery, lowering the risk of addiction and side effects.
What could go wrong: This is a small, early-phase study. Ketamine may not reduce pain or pill use significantly, and it can cause side effects like hallucinations or nausea.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for HEMORRHOIDS are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

hemorrhoid Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEMORRHOIDS

Contacts and locations

Locations

University of Oklahoma Health Sciences Center
RECRUITING

Oklahoma City, Oklahoma, 73104, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.