Vein disorder

This trial is testing two different ways to perform varicocele embolization, a procedure that blocks off enlarged veins in the scrotum to relieve pain and improve fertility. Thirty men with varicocele will receive the procedure either through a vein in the neck (transjugular) or …

This study tests whether placing a stent in a blocked pelvic vein can help heal chronic leg ulcers in people with post-thrombotic syndrome, a complication of deep vein thrombosis. Twenty adults with non-healing venous ulcers will receive the stenting procedure plus standard ulcer…

This study follows over 500 people with chronic venous disease who are taking Ruscus aculeatus L., a plant extract also known as butcher's broom, as part of their routine care. Researchers will track changes in vein-related symptoms, pain, and quality of life over 90 days. The go…

This trial compares two minimally invasive procedures for treating incompetent perforating veins—veins that fail to close properly and can cause leg swelling, skin changes, or ulcers. One method uses a needle to deliver an electric current to seal the vein, while the other inject…

This pilot study is testing whether a low dose of colchicine, a drug usually used for gout, can reduce the risk of post-thrombotic syndrome (PTS) after a deep vein thrombosis (DVT) in the leg. PTS can cause chronic pain, swelling, and skin changes. The trial will enroll 150 adult…

This study tests a one-time procedure done before birth to treat a rare brain blood vessel problem called vein of Galen malformation. The treatment blocks abnormal blood flow while the baby is still in the womb, at or after 34 weeks of pregnancy. About 20 fetuses will be treated,…

This study compares a device that physically removes blood clots from leg veins (ClotTriever) to standard blood-thinning medication alone for people with deep vein thrombosis (DVT). About 300 participants with recent, severe DVT in one leg will be randomly assigned to either trea…

This study looks at whether adding L-carnitine, a natural substance, to standard care can improve outcomes for critically ill adults with liver disease in the ICU. About 58 participants with conditions like liver failure or severe infections will be enrolled. Researchers will tra…

This trial tests whether gentle massage and palm-to-fist tapping near an IV insertion site can reduce the risk of phlebitis, a painful inflammation of the vein. Hospitalized adults with a peripheral IV in their arm are randomly assigned to receive standard care or add these simpl…

This phase 3 trial tests a single injection of SMO1, a dexamethasone implant placed inside the eye, for people with macular edema (swelling) caused by a blocked retinal vein. The study compares SMO1 to an existing dexamethasone implant to see which better improves vision and redu…

This study compares two standard treatments for bleeding internal hemorrhoids: hemorrhoidal artery embolization (HAE) and rubber band ligation (RBL). HAE uses a catheter to block blood flow to the hemorrhoid with tiny particles or coils, while RBL uses rubber bands to cut off cir…

This study tests a new, minimally invasive version of Ferguson hemorrhoidectomy for people with grade III hemorrhoids. The goal is to see if using enhanced visualization tools can reduce pain and speed recovery while keeping the surgery effective. About 50 adults who need hemorrh…

This Phase 2 study tests whether weekly injections of MTX-001, a substance made from human amniotic fluid, can help heal venous stasis ulcers that haven't improved after at least 4 weeks of standard care. About 80 adults aged 18 to 90 with non-infected leg ulcers will receive eit…

This Phase 2 trial tests an experimental drug called EYE103 (Restoret) in 160 people with wet age-related macular degeneration or macular edema from a branch retinal vein occlusion. Participants receive three eye injections of either a low or high dose of EYE103, spaced four week…

This study tests a procedure called rectal artery embolization (RAE) to treat bleeding from internal hemorrhoids. Doctors use imaging to guide tiny particles into the blood vessels feeding the hemorrhoids, blocking blood flow to reduce bleeding. The trial enrolls 20 adults with g…

This study tests whether a single midline incision in the pubic area works as well as the standard two incisions (one on each side) for repairing varicoceles in both testicles. The trial enrolls men aged 18 to 45 with a palpable bilateral varicocele and infertility lasting at lea…

This study tests a new eye injection called KIO-104 for people with macular edema, a condition where fluid builds up in the eye and blurs vision. About 28 adults will receive multiple doses to see if the drug is safe and helps reduce swelling. The goal is to find a steroid-free o…

This study is creating a registry to track how well a procedure called hemorrhoid artery embolization works for people with chronic bleeding internal hemorrhoids. Researchers will follow 1,200 adults for up to 3 years after the procedure, collecting data on bleeding, symptoms, an…

This study compares two ways of placing a stent in the liver to prevent repeat bleeding from swollen veins in the throat or stomach in people with cirrhosis. The standard method fully expands the stent, while the new method uses a smaller balloon to keep it slightly narrower. The…

This study is testing a device called the Surfacer Inside-Out Access Catheter System. It is designed to help patients who have blocked veins in their upper body and cannot get a standard central line. The study will enroll 30 people and track how safely the device works and any s…

This study tests a new catheter system designed to remove blockages in leg veins caused by old blood clots. About 20 adults with painful swelling or pain from chronic vein blockages will receive the treatment. The main goals are to ensure the procedure is safe and to check if it …

This study tests whether adding a laser to standard foam treatment works better for varicose veins. About 102 adults with small-to-medium leg veins will get either foam alone or foam plus a laser. The main goal is to see if the vein closes up more often after 30 days, with fewer …

This study is testing a new device called the Recana Thrombectomy Catheter System to treat chronic blockages in veins. It will include 30 adults with symptoms like leg swelling or pain due to venous obstruction. The device is inserted into the vein to remove the blockage and rest…

This study tests whether adding the blood thinner apixaban to the heart drug carvedilol can prevent complications like bleeding, fluid buildup, and confusion in people with cirrhosis and high blood pressure in the liver. About 220 adults with stable cirrhosis will take either api…

This study tests whether the blood thinner apixaban can dissolve blood clots in the portal vein that develop more than a year after laparoscopic spleen surgery in people with cirrhosis. Twenty participants will take apixaban twice daily, and doctors will use ultrasound or CT scan…

This study looks at whether the blood thinner apixaban can safely dissolve blood clots in the portal vein (the main vein to the liver) that appear more than a year after spleen removal surgery. It involves 20 adults with cirrhosis who had their spleen removed. The goal is to see …

This study tests a newer, ultrasound-guided endoscopic technique to prevent repeat bleeding from enlarged veins in the stomach or esophagus of liver cancer patients. About 84 adults who recently had such bleeding controlled by standard endoscopy will be randomly assigned to recei…

This study compares two minimally invasive procedures for grade II/III hemorrhoids: radiofrequency ablation (using heat) and Doppler-guided artery ligation with mucopexy (tying off blood vessels). The goal is to see if the newer heat-based method is as good as the standard one at…

This study tests two different laser wavelengths (1470 nm and 1940 nm) for a procedure called laser crossectomy to treat varicose veins. The goal is to see which wavelength better prevents vein reflux from returning at the groin junction, while also checking for pain and side eff…

This Phase 3 trial tests whether a gel called TR987, applied to the skin, can help heal chronic leg ulcers caused by poor blood flow. About 312 adults with venous leg ulcers will receive either the gel plus standard wound care or standard care alone. The main goal is to see if th…

This study is testing a new way to treat moderate-to-severe hemorrhoids by combining a laser procedure with a stitch technique. About 100 adults will receive the treatment and be followed for a year. The goal is to see if it reduces pain, bleeding, and tissue prolapse better than…

This study tests whether special wraps made from human placental membrane can help heal diabetic foot ulcers and venous leg ulcers that won't close on their own. About 50 adults with diabetes or venous disease will receive weekly applications of one of four placental membrane pro…

This study tests whether using a simple urine test to guide the dose of a water pill (furosemide) can safely and effectively remove excess fluid after heart surgery. About 102 adults having heart surgery with a heart-lung machine will be randomly assigned to either standard care …

This study is testing whether adding rosuvastatin (a common cholesterol-lowering drug) to standard blood thinner treatment can lower the risk of another blood clot in people who have recently had a deep vein thrombosis or pulmonary embolism. About 2,700 participants will receive …

This study tests a combination of an experimental immunotherapy (QL1706), a blood vessel blocker (bevacizumab), and chemotherapy given directly into the liver artery for people with advanced liver cancer that has caused a clot in the main portal vein. The goal is to see if this a…

This study looks at a two-part procedure to prevent repeat bleeding in people with cavernous transformation of the portal vein, a rare condition where the main vein to the liver is blocked. The procedure involves blocking the bleeding veins and partially blocking the splenic arte…

This study tests whether vonoprazan, a stomach acid blocker, can prevent ulcers that often form after endoscopic variceal band ligation (EVBL) in people with liver cirrhosis. About 154 adults will take either vonoprazan or a placebo daily for 14 days after the procedure. Research…

This study tests whether a minimally invasive procedure called Superior Rectal Artery Embolization (SRAE) works as well as rubber band ligation for controlling bleeding from hemorrhoids. SRAE blocks blood flow to the hemorrhoids using tiny particles, and is done under local anest…

This study tests a special stent called LIVERTY TIPS, placed in the liver to create a new pathway for blood flow in people with cirrhosis and high blood pressure in the liver. The goal is to see if it can keep the new channel open and reduce problems like bleeding or fluid buildu…

This study tests whether taking a blood thinner (rivaroxaban) plus aspirin after a vein-stenting procedure keeps the vein open longer and prevents new clots. About 172 people with deep vein thrombosis and narrowed iliac veins will receive the combination for 6 months (rivaroxaban…

This study is testing a new, non-invasive way to detect high-risk varices (enlarged veins) in the esophagus and stomach of people with liver cirrhosis. Instead of using a camera down the throat (endoscopy), doctors will use a special ultrasound technique called SHAPE, along with …

This study tests a new MRI contrast agent called ferumoxytol, made from iron nanoparticles, to see if it can safely and effectively image veins in people with vein diseases. Current dyes can be risky for patients with kidney problems, but ferumoxytol may be safer and last longer …

This study is testing whether a non-invasive ultrasound of the spleen can accurately detect dangerous vein swelling and high blood pressure in the liver. Researchers will enroll 450 adults with advanced chronic liver disease. If successful, this simple scan could replace the curr…

This study tests whether giving blood-thinning medicine after varicose vein surgery can prevent dangerous blood clots in the legs or lungs. About 1 in 50 people develop a clot after these procedures. The trial will enroll 3,175 adults and compare those who receive the medicine to…

This trial tests a device called the Pedal Pump, which moves the feet for 10 minutes to help reduce lower leg swelling (edema) in hospitalized patients. The study includes 60 adults with edema due to conditions like heart failure, kidney disease, or chronic venous insufficiency. …

This study will compare three surgical treatments for severe internal hemorrhoids: laser, energy therapy, and traditional surgery. About 60 adults with grade III hemorrhoids will choose their preferred treatment. The goal is to see which method provides less pain after surgery an…

This study tests whether a procedure called ovarian and pelvic vein embolization can reduce chronic pelvic pain in women with pelvic varicose veins. Forty women with severe pain lasting over six months will be randomly assigned to either the embolization procedure or a diagnostic…

This study tests whether a 3-week thermal spa treatment at the Saint-Eloy center can relieve symptoms of severe chronic venous insufficiency (a condition where leg veins have trouble sending blood back to the heart). About 84 adults with severe vein disease will receive either th…

This study will follow 60 adults who are having laser surgery for internal hemorrhoids. Researchers will measure pain after surgery, how long people stay in the hospital, and how satisfied patients are with the results. The goal is to understand how well this laser procedure work…

This study tests a new surgical technique called SHAPE against the standard Milligan-Morgan surgery for people with severe (third- and fourth-degree) hemorrhoids. The goal is to see if SHAPE causes less pain after surgery and leads to fewer complications. About 68 adults will tak…

This study tests a specially designed nursing program for people recovering from varicose vein surgery. The program focuses on teaching patients how to manage their own recovery, including daily activities and medical care. Researchers will measure whether this approach improves …

This study is testing a new portable device called Dayspring that uses active compression to reduce leg swelling from lymphedema or phlebolymphedema. It will involve 100 veterans and measure cost savings, mobility, and symptom severity. The device is non-pneumatic, meaning it doe…

This study compares two treatments for varicose veins: foam sclerotherapy (injecting a foam to close the vein) and mechanochemical ablation (using a device and medication). Both are done with local anesthesia and allow quick recovery. 50 patients will be randomly assigned to one …

This study tests a special adhesive patch made with zinc oxide to hold catheters (thin tubes placed in veins) in place for hospitalized adults. The goal is to see if it reduces complications like the catheter moving, skin irritation, vein swelling, and pain. About 400 patients wh…

This study tests whether giving ketamine during hemorrhoid surgery can reduce the amount of strong pain pills patients need afterward. About 100 adults with severe hemorrhoids will be randomly assigned to receive either ketamine or a placebo during their operation. Researchers wi…

This study tests two types of nerve blocks to control pain after hemorrhoid surgery. One group gets a pudendal block, the other a sacral ESP block, both using the same numbing medicine. Researchers will measure pain levels and how quickly patients recover. The goal is to find whi…

This study tests whether injecting botulinum toxin (Botox) into the anal muscle one week before hemorrhoid removal surgery can lower pain after the operation. About 292 adults with severe hemorrhoids will get either Botox or a placebo injection before surgery. Researchers will tr…

This study compares two laser wavelengths (1470 nm and 1940 nm) for treating varicose veins in the legs. About 280 participants will receive one of the two laser treatments and be followed for five years. The goal is to see if the newer 1940 nm wavelength works as well as the sta…

This study tests whether a long-acting numbing drug called liposomal bupivacaine can control pain for up to 72 hours after hemorrhoid surgery better than standard numbing medicine. About 156 adults having hemorrhoid surgery will receive either the long-acting drug or regular bupi…

This study tests a procedure called hemorrhoidal artery embolization (HAE) for people with internal hemorrhoids who have not had success with other treatments or cannot have surgery. The procedure blocks certain arteries to reduce blood flow to the hemorrhoid tissue, aiming to im…

This study looks at whether wrist-ankle acupuncture can reduce pain after perianal surgery. About 58 adults with moderate to severe pain will receive this acupuncture along with standard care. Researchers will measure pain relief and how often extra pain medicine is needed.

This study looks at whether different exercise programs can improve blood flow in the legs of older adults with poor circulation. About 425 participants will be split into groups doing either mixed exercise, high-intensity rowing, or vibration exercise for 12 weeks. The goal is t…

This observational study looks at whether a cream containing nifedipine 0.3% and lidocaine 1.5% can reduce symptoms like pain, bleeding, and prolapse in people with acute uncomplicated hemorrhoids. About 80 adults aged 18 to 75 who have already started this cream as part of their…

This study tests whether using virtual reality during varicose vein surgery can reduce pain and anxiety enough to avoid standard sedation. About 400 adults will either receive virtual reality or standard medication. The goal is to see if VR can make the procedure more comfortable…

This study tests whether a new ultrasound-guided nerve block (sacral erector spinae plane block) can control pain after hemorrhoid removal as well as the standard saddle block. Fifty adults undergoing hemorrhoidectomy will be randomly assigned to one of the two methods. Researche…

This study aims to see if a common vein treatment called radiofrequency ablation is safe and helpful for people aged 80 and older with severe chronic venous insufficiency. About 50 participants will receive the procedure and be followed for 6 months. The goal is to measure how we…

This study tests a device that delivers oxygen to chronic leg ulcers caused by vein problems. About 212 adults will get either the real oxygen therapy or a sham treatment, along with standard compression bandages, for up to 16 weeks. The main goal is to see if the oxygen therapy …

This study compares two ointments—lignocaine and glyceryl trinitrate (GTN)—for pain relief after hemorrhoid removal. Sixty-four adults will apply one of the ointments three times daily after surgery. Researchers will measure pain scores, wound healing time, and patient satisfacti…

This pilot study tests a procedure called trans-radial superior rectal artery embolisation for treating hemorrhoids. Instead of surgery, doctors access an artery in the wrist to block blood flow to the hemorrhoid, which may reduce bleeding and pain. The study will enroll 20 adult…

This study is observing 400 people aged 12 and older who have noncirrhotic portal hypertension (NCPH) or are at risk for it. NCPH is a liver condition that increases blood pressure in the liver's blood vessels without causing cirrhosis, and often has no early symptoms. Researcher…

This study looks at whether vein problems are linked to pain, swelling, and daily function in women with lipedema. Researchers will use ultrasound to check leg veins and ask participants about their symptoms. The goal is to better understand how these conditions interact, which c…

This study looks at 400 people with a first-time deep vein thrombosis (DVT) in the leg. Researchers want to see if the amount of clot seen on an ultrasound can predict who will develop post-thrombotic syndrome (PTS), a condition causing long-term leg pain, swelling, and skin chan…

This registry follows 10,000 people with early varicose veins to see how chronic venous disease develops and worsens over time. Researchers will track signs like spider veins, swelling, skin changes, and blood clots using yearly checkups and ultrasound scans. The goal is to bette…

This study looks at whether giving proton pump inhibitors (like omeprazole) to people with cirrhosis who have bleeding in the esophagus causes more complications in the hospital. Researchers will randomly assign 60 adults to receive either the drug or no drug after an endoscopic …

This study compares two types of long IV catheters used in patients whose veins are hard to see or feel. One catheter has a built-in guidewire to help with placement; the other does not. Researchers want to see if the simpler catheter works just as well, lasts as long, and costs …

This study looks at people with high blood pressure in the liver that causes swollen veins in the esophagus and stomach. Researchers will compare those who get an endoscopic procedure (using a camera down the throat) with those who receive other treatments like medicine or surger…

This study follows 2000 people with severe liver-related high blood pressure who receive a TIPS procedure, which creates a bypass in the liver. Researchers will track survival, need for liver transplant, and complications like confusion or liver failure over 12 months. The goal i…

This study looks at whether people with hemorrhoids are more likely to have varicose veins in their legs. Researchers will use ultrasound to check the leg veins of 400 adults—200 with hemorrhoids and 200 without. No treatments or procedures are given; the goal is simply to see if…

This study looks at two ways to teach medical residents how to use a special ultrasound technique (VExUS) to check for fluid overload in patients with acute heart failure. About 23 residents will be trained either in-person or remotely, and their ultrasound skills will be compare…

This study looks at cancer patients who have a type of blood clot called superficial venous thrombosis (SVT). About 15-20% of SVTs happen in people with cancer, but there are no clear treatment guidelines for them. Researchers will observe 1,576 patients to see how different bloo…

This study tests whether a new EUS-guided pressure measurement (EUS-PPGM) can predict how well varices respond to endoscopic banding in people with cirrhosis. Researchers will measure portal pressure in 160 patients and follow them for one year to see if higher pressure at 3 mont…

This study tests a new system that uses a special bandage with electrodes to monitor how well venous leg ulcers are healing. The system measures electrical signals through the wound and sends data to a phone app. Twenty adults with chronic leg ulcers will be monitored up to three…

This study looks at factors that help blood clots in the main liver vein dissolve in people with liver scarring (cirrhosis) and enlarged stomach veins. Researchers will follow 1,500 patients over time to see what influences clot recovery. The goal is to help doctors and patients …

This study aims to validate the Caprini score, a tool that estimates blood clot risk, in 3,000 people undergoing varicose vein surgery. Participants will be followed for four weeks after procedures like laser treatment or vein stripping to see if the score accurately predicts who…

This study is creating a large collection of medical data and biological samples from 1000 people with portal hypertension, a condition that can cause dangerous bleeding in the esophagus or stomach. The goal is to use advanced technologies like genetics and imaging to better unde…

This study follows 35 people with severe obesity who are having mini-gastric bypass surgery. Researchers want to see how the surgery changes body composition and improves related health issues like type 2 diabetes, sleep apnea, high blood pressure, and fatty liver disease. The go…

This observational study looks at the best time to take infrared images of varicose veins after a person stands up from lying down. Researchers will take pictures every 5 seconds for 3 minutes in 20 patients with varicose veins. The goal is to improve imaging techniques for bette…

This study is creating a collection of blood, urine, and stool samples from 500 adults with or at risk for heart and blood vessel diseases. Researchers will use these samples to study inflammation, blood clotting, and other biological pathways. The goal is to build a resource tha…

This study looks at how two common endoscopic treatments—band ligation and sclerotherapy—change blood pressure in the liver's portal vein over 3 to 6 months. Researchers will use a special ultrasound-guided technique to measure these pressure changes in 70 adults with cirrhosis a…

This study looks at a rare liver condition called Porto-Sinusoidal Vascular Disease (PSVD), which causes high blood pressure in the liver's veins. Researchers want to see if a procedure called TIPS works as well for PSVD patients as it does for those with cirrhosis. They will com…

This study looks at 48 people with chronic leg swelling to find out why some respond to compression therapy and others don't. Participants will have an MRI and genetic testing to measure fat, muscle, and fluid in their legs. The goal is to better understand the condition, not to …

This study looks at two types of radiation therapy for a slow-growing brain tumor near the cavernous sinus. Researchers want to see if proton therapy causes less long-term harm to thinking and memory than standard photon radiation. About 160 adults aged 18 to 70 will be followed …

This study follows 10,000 people with advanced chronic liver disease at Vienna General Hospital. Researchers will track their health over time, collect blood, urine, and tissue samples, and record complications like bleeding or liver failure. The goal is to better understand how …

This study from King's College London focuses on how to better identify early skin changes from chronic venous insufficiency (CVI) in people with dark skin tones. Researchers will interview patients about their experiences and test new assessment techniques, like using touch and …

This observational study follows 700 adult liver transplant recipients to understand how portal vein thrombosis (a blood clot in the liver's main vein) impacts their recovery and long-term health. Researchers will compare those with and without the clot to identify risk factors a…

This study is testing whether a new imaging device called MIMOSA Pro can measure oxygen levels in leg tissue as accurately as standard tests like ankle-brachial index or Doppler ultrasound. Researchers will compare the device's readings to those from traditional methods in 60 adu…

This study looks at fetal cells that remain in a mother's blood after pregnancy, called fetal microchimeric cells, in women with chronic skin ulcers like venous or diabetic ulcers. Researchers will analyze these cells' genetic activity to see if they might help with wound healing…

The European Venous Registry (EVeR) is collecting data from 100 patients with deep vein disease in the legs to track how different treatments work over 10 years. Researchers will measure symptoms and quality of life to find out which approaches are most effective. This is an obse…