Amniotic fluid shots aim to heal stubborn leg wounds
NCT ID NCT04647240
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This Phase 2 study tests whether weekly injections of MTX-001, a substance made from human amniotic fluid, can help heal venous stasis ulcers that haven't improved after at least 4 weeks of standard care. About 80 adults aged 18 to 90 with non-infected leg ulcers will receive either MTX-001 or a placebo. Researchers will track wound size reduction, complete closure, and pain changes over time.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
MTX-001 (human amniotic fluid)
What this could lead to
If it works, this could offer a new treatment option for people with chronic venous leg ulcers that don't heal with standard care.
What could go wrong
This is an early Phase 2 trial with only 80 participants, so results may not apply to everyone. The treatment involves weekly injections, and safety and effectiveness are still being studied.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Site 01
RECRUITINGSalem, Virginia, 24153, United States
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Site 02
RECRUITINGTucson, Arizona, 85715, United States
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Site 03
RECRUITINGFresno, California, 93710, United States
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Site 04
RECRUITINGNew Hyde Park, New York, 11042, United States
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Site 08
RECRUITINGCircleville, Ohio, 43113, United States
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Site 12
RECRUITINGVista, California, 92081, United States
Contact Phone: •••-•••-••••
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Site 13
RECRUITINGTampa, Florida, 33647, United States
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Site 14
RECRUITINGOpelousas, Louisiana, 70570, United States
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Site 9A
RECRUITINGSan Francisco, California, 94115, United States
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Site 9B
RECRUITINGSan Francisco, California, 94117, United States
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Site 9C
RECRUITINGCastro Valley, California, 94546, United States