Amniotic fluid shots aim to heal stubborn leg wounds

NCT ID NCT04647240

Recruiting now Disease control Sponsor: Merakris Therapeutics Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Phase 2 study tests whether weekly injections of MTX-001, a substance made from human amniotic fluid, can help heal venous stasis ulcers that haven't improved after at least 4 weeks of standard care. About 80 adults aged 18 to 90 with non-infected leg ulcers will receive either MTX-001 or a placebo. Researchers will track wound size reduction, complete closure, and pain changes over time.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: MTX-001 (human amniotic fluid)
What this could lead to: If it works, this could offer a new treatment option for people with chronic venous leg ulcers that don't heal with standard care.
What could go wrong: This is an early Phase 2 trial with only 80 participants, so results may not apply to everyone. The treatment involves weekly injections, and safety and effectiveness are still being studied.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

ulcer of lower limbs Varicose Ulcer venous insufficiency

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

VENOUS LEG ULCER VENOUS STASIS ULCER

Contacts and locations

Locations

Site 01
RECRUITING

Salem, Virginia, 24153, United States
Site 02
RECRUITING

Tucson, Arizona, 85715, United States
Site 03
RECRUITING

Fresno, California, 93710, United States
Site 04
RECRUITING

New Hyde Park, New York, 11042, United States
Site 08
RECRUITING

Circleville, Ohio, 43113, United States
Site 12
RECRUITING

Vista, California, 92081, United States
Site 13
RECRUITING

Tampa, Florida, 33647, United States
Site 14
RECRUITING

Opelousas, Louisiana, 70570, United States
Site 9A
RECRUITING

San Francisco, California, 94115, United States
Site 9B
RECRUITING

San Francisco, California, 94117, United States
Site 9C
RECRUITING

Castro Valley, California, 94546, United States

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