Ulcer of lower limbs

This study tests a special wound dressing called Hyalomatrix, made from hyaluronic acid, to see if it helps heal chronic venous leg ulcers faster than standard care alone. About 122 adults with leg ulcers that haven't healed for at least 4 weeks will take part. The main goal is t…

This Phase 2 study tests whether weekly injections of MTX-001, a substance made from human amniotic fluid, can help heal venous stasis ulcers that haven't improved after at least 4 weeks of standard care. About 80 adults aged 18 to 90 with non-infected leg ulcers will receive eit…

This study tests whether a special placental graft, used alongside standard wound care, helps close diabetic foot ulcers that won't heal on their own. About 350 adults with type 1 or 2 diabetes and a foot ulcer between 1 and 15 cm² will be randomly assigned to get the graft plus …

This study tests a device that uses light and magnets (COMS) to help heal chronic leg ulcers. About 122 people with venous leg ulcers will receive either standard care plus COMS or standard care alone. The goal is to see if the device speeds up wound healing and improves quality …

This study is testing a new skin graft made from donated amniotic tissue to help heal venous leg ulcers, which are slow-healing wounds caused by poor blood flow. Ten adults with a leg ulcer between 1 and 30 square centimeters will receive the graft and be monitored for up to 13 w…

This study tests a new way to create living skin during surgery for wounds that won't heal easily. Doctors take a small piece of the patient's own skin, separate out stem cells, and spray them onto a scaffold that is placed on the wound. The goal is to see if this helps wounds cl…

This phase 2 trial tests whether injecting antibiotics directly into the tissue around chronic wounds helps them heal better than standard care alone. About 60 adults with non-healing wounds on their legs, arms, or trunk will either receive the antibiotic injections plus usual wo…

This study tests a new hydrogel made with plasma-activated water on chronic wounds like diabetic foot ulcers and pressure sores. Fifty adults will either get the gel or standard wound care for 12 weeks. Researchers will check if the gel helps wounds close faster and lowers bacter…

This study tests a new medical device called the GORE VIAFORT stent, which is a small mesh tube placed inside a blocked or narrowed vein in the leg or pelvis to keep it open. The goal is to improve blood flow and reduce symptoms like pain, swelling, and leg ulcers. About 165 adul…

This study compares two types of skin grafts (PelloGraft and SanoGraft) to standard wound care for healing diabetic foot ulcers and venous leg ulcers. About 180 adults with chronic wounds will be enrolled. The goal is to see if these grafts help wounds close completely within 12 …

This study tests whether a special wound dressing made from donated placental tissue, called NuShield, can help heal venous leg ulcers that won't close on their own. About 200 adults with these ulcers will receive either NuShield plus standard wound care or standard care alone. T…

This study tests a gel called EscharEx, made from pineapple enzymes, to remove dead tissue from hard-to-heal leg ulcers. About 216 adults with venous leg ulcers will receive either the active gel or a placebo. The goal is to see if the gel safely and effectively cleans the wound …

This study is testing a device called the TrueLok Elevate that uses a technique called transverse bone transport to help heal chronic lower limb ulcers. The device is attached to the leg and slowly moves a piece of bone to stimulate blood flow and tissue healing. Researchers will…

This study compares two versions of a special wound dressing for infected leg ulcers. One has an extra protective film on top. About 150 adults with infected leg ulcers will be randomly assigned to one dressing or the other, along with compression therapy. The main goal is to see…

This study is testing whether a gel made from a patient's own blood (platelet-rich fibrin) can help heal chronic leg ulcers that won't go away. About 40 adults over 35 with non-infected leg sores will receive the gel dressing. The goal is to see if the gel improves wound healing …

This study tests whether adding a placental-based skin substitute to standard wound care helps close hard-to-heal diabetic foot ulcers faster than standard care alone. About 272 adults with diabetes and a foot ulcer present for 4 to 52 weeks will receive either the skin substitut…

This study tests a gel called ZKARE® for treating chronic ulcers that won't heal on their own. About 134 people with pressure sores, diabetic foot ulcers, or leg ulcers will either get the gel plus standard care, or standard care alone. The goal is to see if the gel helps wounds …

This study tests whether a special graft made from donated placental tissue, called XWRAP, can help heal diabetic foot ulcers that won't close with standard care alone. About 60 adults with type 1 or type 2 diabetes will receive either the graft plus standard wound care or standa…

This Phase 3 trial tests whether a gel called TR987, applied to the skin, can help heal chronic leg ulcers caused by poor blood flow. About 312 adults with venous leg ulcers will receive either the gel plus standard wound care or standard care alone. The main goal is to see if th…

This study tests whether special wraps made from human placental membrane can help heal diabetic foot ulcers and venous leg ulcers that won't close on their own. About 50 adults with diabetes or venous disease will receive weekly applications of one of four placental membrane pro…

This Phase 3 trial is testing a drug called Neovasculgen, given as injections into the leg muscles, to see if it can help heal foot ulcers in people with diabetes. The study will include 144 adults with type 1 or type 2 diabetes who have a non-healing foot ulcer. Participants wil…

This study tests whether a special placental membrane called BR-AC, applied weekly, can help heal non-healing venous leg ulcers faster than standard care alone. About 60 adults with a leg ulcer between the knee and ankle will be randomly assigned to get either standard care plus …

This study tests whether special dressings made from placental membrane can help diabetic foot ulcers heal faster. About 30 adults with diabetes and a chronic foot ulcer will receive the placental dressing. Their healing progress will be compared to similar patients who received …

This study tests a wound dressing called Miro3D, made from pig liver tissue, to see if it helps heal hard-to-treat wounds like diabetic foot ulcers and pressure ulcers. Up to 20 adults will receive the dressing along with standard care for up to 12 weeks. Researchers will measure…

This study tests whether adding a special wound dressing called Miro3D to standard care helps diabetic foot ulcers heal faster. About 30 adults with Wagner Grade 1 foot ulcers will be randomly assigned to get either Miro3D plus standard care or standard care alone. The main goal …

This study tests a special wound covering made from donated placental tissue, called DermaBind TL, in 150 adults with diabetic foot or venous leg ulcers that won't heal. The goal is to see if the graft safely helps shrink or close the wound over 13 weeks. Participants must be 18-…

This study is testing a special soft cast for people with diabetic foot ulcers. The cast is a multi-layer wrap that cushions the foot and leg to help the wound heal. Researchers want to see if it works well, is comfortable, and safe. About 100 adults with diabetic foot ulcers wil…

This study tests a new antibacterial absorbable dressing on 30 adults with chronic non-healing wounds. The dressing is designed to break down in the body and help wounds heal faster. Researchers will measure how much the wound shrinks after 3 weeks and how many wounds fully close…

This study tests whether a special tri-layer amnion graft or a single-layer amnion graft can help heal diabetic foot ulcers and venous leg ulcers that have not improved with standard care. About 165 adults with wounds between 2 and 25 cm² that have been open for over 4 weeks will…

This study explores whether a high-resolution ultrasound can better monitor healing in chronic wounds like diabetic foot ulcers. Ten participants will have their wounds scanned and biopsied to see if the ultrasound matches standard assessments. If it works, it could offer a painl…

This study is testing a software tool called Belle.ai that uses artificial intelligence to help doctors diagnose common skin diseases. About 400 patients at dermatology clinics will have three photos taken of their skin condition. The AI will analyze the photos and suggest possib…

This early study is testing a mineral-based spray called THERAVEX on 26 people with various wounds, including burns, pressure sores, and diabetic ulcers. The spray is used alongside standard wound care to see if it helps the skin heal better and faster. So far, it appears safe an…

This study tests a new liquid treatment for chronic wounds like leg and foot ulcers. The goal is to clean the wound by removing dead tissue and bacteria, which may help it heal. About 80 people aged 60 and older will be randomly assigned to get either the new treatment or a stand…

This study tests whether a cold helium plasma device is safe and tolerable for people with chronic wounds, such as leg ulcers or pressure sores. About 40 adults with wounds that have not healed for over 4 weeks will receive the treatment. The goal is to see if cold plasma can red…

This study tests a group counseling program called Healing HEARTS to help people with conditions like obesity, skin disease, cancer, HIV, diabetes, or chronic pain deal with internalized stigma. Participants will either join the counseling program or a peer support group. The goa…

This study looks at whether repairing blocked leg blood vessels within 48 hours helps heal foot ulcers in people with type 2 diabetes faster than waiting for a scheduled procedure. About 200 adults with diabetic foot sores will be randomly assigned to early or standard treatment.…

This study tests a new two-sided pad (Debrisoft Duo) for cleaning wounds by removing dead tissue. About 104 adults with various wound types (like diabetic ulcers or burns) will be randomly assigned to the new pad or the current one-sided pad. The main goal is to see if the new pa…

This study is testing a pad used to clean wounds, such as diabetic ulcers, leg ulcers, pressure sores, surgical wounds, and burns. The goal is to see if the pad safely removes debris and improves the wound bed right after use. About 184 adults with these types of wounds will take…

This study tests a device that delivers oxygen to chronic leg ulcers caused by vein problems. About 212 adults will get either the real oxygen therapy or a sham treatment, along with standard compression bandages, for up to 16 weeks. The main goal is to see if the oxygen therapy …

This study looks at why wounds heal slowly or not at all in people with diabetes. Researchers will collect blood and wound fluid from 250 adults with chronic wounds to compare immune cells between diabetic and non-diabetic participants. The goal is to understand the biological re…

This study collects biological samples—like blood, skin biopsies, and swabs—from people with or at risk for skin diseases, as well as healthy volunteers. Researchers will use these samples to study the causes of skin conditions and explore potential treatments. Up to 700 particip…

This study looks at genetic and epigenetic changes in chronic wounds that don't heal normally. Researchers will compare tissue from the wound with blood samples from 256 adults to find genetic signatures linked to healing. The goal is to understand why some wounds heal and others…

This study follows 50 people whose diabetic foot ulcers healed in a previous trial. They will use a BlueDrop foot scanner at home each morning to take photos and thermal images, which are sent to a nurse. The goal is to see how often the ulcers come back and whether remote monito…

This study is for people with wounds that have developed hypergranulation (overgrown tissue that slows healing). Researchers will take photos and use a new assessment tool to grade the severity. About 100 adults and children in the UK will take part. The goal is to create a stand…

This study looks at how skin conditions related to cancer or cancer treatments affect the well-being of cancer patients and survivors. About 1,025 participants will fill out questionnaires about their skin condition. The goal is to better understand these effects and improve trea…

This study from King's College London focuses on how to better identify early skin changes from chronic venous insufficiency (CVI) in people with dark skin tones. Researchers will interview patients about their experiences and test new assessment techniques, like using touch and …

This study is testing whether a new imaging device called MIMOSA Pro can measure oxygen levels in leg tissue as accurately as standard tests like ankle-brachial index or Doppler ultrasound. Researchers will compare the device's readings to those from traditional methods in 60 adu…