Ulcer of lower limbs

This study looks at how well a product made from donated placental tissue helps close hard-to-heal wounds, such as diabetic foot ulcers and venous leg ulcers. Researchers will review medical records of 50 people who received this treatment to see how many wounds fully closed with…

This early study tested a single topical dose of stem cells (XSTEM-VLU) in 6 people with difficult-to-heal venous leg ulcers. The goal was to check safety and see if the treatment helps wounds close faster when added to standard care. Participants were followed for 10 weeks after…

This study tested using cyanoacrylate glue to close off faulty veins that cause painful leg ulcers. 38 people with venous leg ulcers received the glue treatment. The goal was to see if the procedure is safe and helps ulcers heal faster.

This study tests whether using telemedicine (remote doctor visits) helps heal chronic wounds better than usual in-person care. Adults with long-lasting wounds in the Languedoc-Roussillon region of France are randomly assigned to telemedicine or standard treatment. The main goal i…

This study tested a new way to treat venous leg ulcers, which are slow-healing wounds on the lower leg. Researchers used ultrasound to push hyaluronic acid gel into the wound and compared it to standard care in 64 patients. The goal was to see if this combination speeds up healin…

This study looked at whether special wraps made from human amniotic membrane can help heal chronic wounds like diabetic foot ulcers, venous leg ulcers, and pressure ulcers. Researchers reviewed data from 500 patients who either received the membrane wraps or standard wound care. …

This study tested whether adding placental tissue grafts to standard wound care helps close diabetic foot and venous leg ulcers faster. 292 adults with nonhealing ulcers received either standard care alone or standard care plus a graft. The main goal was to see if more ulcers clo…

This study followed 191 adults with chronic leg or foot ulcers that hadn't improved for at least 6 months. They received a gel called CACIPLIQ20 added to standard wound care. Researchers tracked how many wounds fully closed within 20 weeks and checked for side effects. The goal w…

This study tested whether adding carbon dioxide (CO₂) therapy to standard wound care helps heal recurrent diabetic foot ulcers. Thirty adults with diabetes and hard-to-heal ulcers received either standard care alone or standard care plus 20 sessions of CO₂ therapy over 4 weeks. T…

This study tested a wound patch called Oasis ECM on 41 people with non-healing sores. The patch is made from natural material to help wounds heal. Researchers measured how much the wounds closed and how patients felt about their quality of life.

This study tested whether a special dressing made from a patient's own platelets (platelet-rich plasma) helps chronic wounds heal better than a standard saline dressing. One hundred adults with long-lasting skin ulcers, including diabetic foot ulcers, took part. The goal was to s…

This study tested a special wound dressing called Symphony™ against standard care for people with diabetic foot ulcers that won't heal. 143 adults with mild to moderate ulcers took part. The goal was to see if Symphony™ helps more ulcers close completely within 12 weeks and how q…

This pilot study tested a staged application of two wound dressings (Endoform and Symphony) on 44 adults with chronic diabetic foot ulcers. The goal was to see if the treatment could fully close the wound within 12 weeks. Researchers measured healing rates, wound size reduction, …

This study tested a new way to help heal chronic wounds on the legs or feet of people with diabetes. The treatment involves applying carbon dioxide gas directly to the wound to improve blood flow and oxygen release. 120 adults with diabetes and non-healing ulcers took part to see…

This study looked at 240 adults with chronic or acute wounds to confirm that a silver-coated dressing (Silver II Non-Woven) is safe and works as intended. Researchers checked for signs of infection and asked clinicians how easy the dressing was to use. The dressing is already on …

This study tested a borate-based bioactive glass wound matrix (Mirragen) plus standard care against standard care alone for diabetic foot ulcers. 148 adults with diabetes and a foot ulcer were enrolled. The main goal was to see if the glass dressing helped more wounds close compl…

This phase 2 pilot study tested a topical ointment called MEBO on venous leg ulcers. Only 5 people took part, and they were randomly assigned to get either MEBO or standard compression bandages. The main goal was to see if the ulcer healed completely within 8 weeks. Because the s…

This study tested whether a tri-layer amnion/chorion/amnion graft (Artacent-AC) plus standard care helps heal chronic diabetic foot ulcers better than standard care alone. 30 adults with diabetes and non-healing foot sores took part. The main goal was to see if the wound fully cl…

This study tested two types of skin substitutes for treating venous leg ulcers, which are slow-healing sores caused by poor blood flow in the legs. Sixty adults with these ulcers received either a collagen-based skin substitute or a dehydrated human amnion/chorion membrane, both …

This study tested whether a beta-blocker eye drop called timolol, applied directly to the wound, can help heal venous leg ulcers that have not improved with standard care. Forty-two adults with ulcers lasting at least 24 weeks received either timolol plus standard wound care or s…

This study compared an automatic ABPI device (MESI MD) with the standard manual device (Huntleigh Dopplex) in 46 patients with lower limb ulcers. The goal was to see if the automatic device gives similar scores and ulcer classifications, potentially reducing waiting times and dis…

This study tested a new, standardized process for providing assistive devices (like special tools) to help people put on and take off compression stockings. 220 adults who need these stockings long-term took part. The goal was to see if the new method improves how often people us…

This study looked at whether two silicone dressings (RespoSorb Silicone and RespoSorb Silicone Border) help heal long-lasting leg and foot wounds. 80 adults with venous leg ulcers or diabetic foot ulcers took part. The main goal was to see if the dressings reduce wound size, and …

This study tested a chemical gel that dries out wound debris against standard scraping (curettage) for cleaning venous leg ulcers. 80 participants with ulcers at least 6 weeks old were included. The goal was to see which method is safer and more effective at reducing wound size a…

This study looked at how well a special dressing called Aquacel WSF Ribbon works for healing foot ulcers and other wounds in everyday medical practice. Researchers reviewed the medical records of 214 people who used this dressing. The main goal was to see how long it took for wou…

This study tested whether listening to music during wound dressing changes can help reduce pain and anxiety in people with venous leg ulcers. 97 patients were split into three groups: one listened to Turkish instrumental music, one to Western music without lyrics, and one had no …

This study tested two special wound dressings—AQUACEL® Ag+ Extra™ and Cutimed® Sorbact®—in 203 adults with venous leg ulcers. The goal was to see which one helps wounds heal better over 12 weeks. Participants had ulcers for at least 2 months and received compression therapy. The …

This study looked at whether a special interactive dressing (UrgoStart Plus) used with compression bandages can help heal venous leg ulcers faster than standard dressings. Sixty adults with chronic leg ulcers were treated for up to 12 weeks. The goal was to see if the new dressin…

This study tested whether using genetic information to guide surgical cleaning (debridement) could improve healing in people with hard-to-heal venous leg ulcers. Researchers analyzed genes and proteins from wound samples before and after the procedure. The goal was to see if this…

This study looked at how doctors in the UK currently diagnose and manage venous leg ulcers. Researchers surveyed 135 primary care doctors and vascular specialists to understand current practices and what guidelines are needed. The goal is to find the most effective and cost-effic…

This study looked at how compression therapy changes oxygen levels in the skin of people with leg ulcers that involve both arteries and veins. Researchers measured oxygen before and during compression in 38 adults. The goal was to better understand how compression works and how w…

This completed study from Versailles Hospital looked back at 200 medical reports of adults with skin injuries like cuts, scrapes, burns, and leg ulcers. The goal was to see how well pain was controlled during treatment. Researchers also interviewed some patients and staff to chec…

This study tested an artificial intelligence algorithm designed to help primary care doctors decide whether a patient with a skin condition really needs to see a dermatologist. Researchers enrolled 200 adults with skin problems and had their doctors take photos of the affected ar…

This study looked back at photos from a previous trial to confirm how well two types of wound dressings helped close venous leg ulcers. Researchers checked if wounds had fully healed (100% skin coverage) by 12 weeks. The goal was to make sure the original results were accurate by…

This study collected fluid from the wounds of 13 people with hard-to-heal leg ulcers. Researchers analyzed the fluid to see how it affects skin cells and bacteria. The goal was to learn more about why some wounds don't heal, not to test a new treatment.

This study tested whether a smartphone app called MyDerm can help patients and doctors monitor chronic leg wounds from home. 25 adults with a single leg wound that had lasted more than 6 weeks took part. Patients used the app to take photos of their wound and answer questions abo…

This study tested a computer program called ACE that helps nurses decide which products to use for treating chronic wounds. Researchers compared outcomes when nurses used ACE versus their usual approach in 73 patients across 18 clinics. The goal was to see if the tool improves he…

This study followed 104 people with venous leg ulcers to see which factors were linked to complete healing after 24 weeks. Researchers looked at medical history, wound size, and also psychological and social factors like mood and self-esteem. The goal was to find better ways to p…

This study looked at whether using telemedicine (video or phone consultations) can help people in rural communities with leg wounds get specialist care more quickly. Researchers compared the time from when a wound was found to when a specialist saw the patient, either through tel…