Could an eye drop cure Hard-to-Heal leg sores?
NCT ID NCT02422017
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study tested whether a beta-blocker eye drop called timolol, applied directly to the wound, can help heal venous leg ulcers that have not improved with standard care. Forty-two adults with ulcers lasting at least 24 weeks received either timolol plus standard wound care or standard care alone for 12 weeks. The goal was to see if timolol could shrink the ulcer by at least 40% or lead to complete healing.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- timolol (a beta-blocker eye drop applied directly to the ulcer)
- What this could lead to
- If it works, this could offer a simple, low-cost way to help stubborn venous leg ulcers heal faster.
- What could go wrong
- This is a small Phase 2 trial with only 42 people, so results may not apply to everyone. Timolol is a beta-blocker and could cause heart-related side effects when absorbed through the skin.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for VENOUS LEG ULCERS are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
CHU Amiens
Amiens, 80054, France
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Placental patch could speed healing of stubborn leg wounds
- Cord tissue dressings aim to heal stubborn leg wounds
- New gel could replace scraping for leg ulcer cleaning
- Sound waves instead of surgery: new device tested for vein disease
- Vitamin B5 injections could speed up chronic wound healing
- New tool aims to spot wound healing hurdles early