Skin disorder

Researchers are testing a new cell therapy called CARCIK CD123/33 in adults and children whose acute myeloid leukemia or BPDCN has come back or stopped responding to standard treatment. The therapy uses immune cells from a donor that are engineered to recognize two proteins, CD12…

Researchers are testing whether ear drops made from Prunus salicina (a type of plum) extract can treat otomycosis, a fungal infection of the ear canal. The trial compares two versions of the plum extract drops, one with chitosan nanoparticles, against standard clotrimazole antifu…

Researchers are testing a new cell therapy called QH103, made from donor γδ T cells engineered to target CD19 on B cells. The trial enrolls adults with severe autoimmune diseases such as lupus, scleroderma, and vasculitis that have not responded to standard treatments. The goal i…

Researchers are testing a new immune cell therapy called CD5 CAR-T in people with mature T-cell lymphomas that have come back or stopped responding to standard treatment. The trial enrolls about 36 participants, ages 14 to 70, who have few remaining options. Participants receive …

This study tests the Shingrix vaccine in people with HIV and healthy volunteers to see how well it boosts immunity against shingles. Participants receive two shots two months apart and are followed for a year. The goal is to understand if the vaccine works safely in those with di…

This study looks at how well the shingles vaccine Shingrix works in people who have had a stem cell transplant. About 55 adults who received the vaccine at least a year after their transplant will have their immune responses measured. Researchers want to see if the timing of the …

This study tests a new chickenpox vaccine called NBP608 in about 780 children aged 1 to 12 years. The vaccine is compared to licensed vaccines to see how well it triggers immunity and if it is safe. Children receive one or two shots, and researchers monitor their immune response …

Researchers are testing an experimental mRNA vaccine called ABO1108 to see whether it can prevent herpes zoster, the painful rash also known as shingles. The trial enrolls adults aged 40 and older, including people whose long-term conditions are stable. Participants receive two i…

This early-phase study tests a new treatment called TI-0032-III for people with severe autoimmune diseases like lupus and scleroderma that haven't improved with standard care. The treatment uses a special injection to create CAR-T cells inside the body, which then target and dest…

This Phase 1 trial tests the safety and tolerability of a new drug called AZD5492 in 72 adults with lupus, myositis, or rheumatoid arthritis. Participants receive one or two doses under the skin and are monitored for side effects and how the drug moves through the body. The study…

This early-stage trial tests an experimental treatment called QEL-005 for people with two serious autoimmune conditions: diffuse cutaneous systemic sclerosis and difficult-to-treat rheumatoid arthritis. QEL-005 is made from a patient's own white blood cells, which are genetically…

This early study tests baricitinib, a drug already approved for other immune conditions, in 20 people with Job syndrome who also have lupus-like disease or eczema. Participants take the pill daily for 6 months. The main goal is to see if it is safe and tolerable, while also check…

This phase 2 trial tests whether an investigational medicine called SPY072 can improve hidradenitis suppurativa (HS), a chronic skin condition causing painful lumps and tunnels. About 150 adults with moderate-to-severe HS who are already receiving standard care will be randomly a…

This study tests whether adding axelopran, a drug that blocks opioid side effects in the gut, to the immunotherapy nivolumab can help people with advanced melanoma that no longer responds to PD-1 inhibitors. The trial includes about 28 adults with unresectable or metastatic cutan…

This study tests whether adding cetuximab to standard immunotherapy (pembrolizumab) helps people with advanced head and neck cancer that has stopped responding to platinum chemotherapy live longer. About 158 adults with cancer that has returned or spread will receive either pembr…

Researchers are testing HS-20137, an antibody designed to block IL-23, a protein that drives inflammation in psoriasis. The study enrolls about 390 adults with moderate-to-severe plaque psoriasis who have had the condition for at least six months. Participants receive 200 mg inje…

This study is testing a new experimental drug called GI-101, given alone or with pembrolizumab or lenvatinib, in people with advanced or metastatic solid tumors (cancers that have spread). The goal is to see if the drug is safe and can shrink or control tumors. About 317 adults w…

This study tests whether omega-3 fatty acid supplements from fish oil, combined with a healthy diet, can reduce disease activity in adults with dermatomyositis, a rare autoimmune disease causing muscle weakness and skin rashes. About 300 participants will take either fish oil cap…

This phase 3 trial is testing whether giving men with metastatic prostate cancer half the standard dose of certain hormone therapies (called ARPIs) can be just as effective as the full dose, while causing less fatigue and fewer treatment stoppages. About 1,500 men with prostate c…

This clinical trial is testing whether the drug nemolizumab can help treat moderate-to-severe atopic dermatitis (a common type of eczema) in Chinese patients aged 12 and older. Participants will receive either nemolizumab or a placebo (a look-alike with no active drug) every four…

This study tests a daily pill called abrocitinib for people with Down syndrome who have eczema or a type of hair loss. About 56 participants will take the drug for up to 60 weeks to see if it safely controls their skin or scalp condition. The goal is to manage symptoms, not cure …

This study tests whether using a device that heats skin lesions to 50°C for 30 seconds can effectively treat cutaneous leishmaniasis in primary health centers in Ethiopia. 103 patients aged 12 to 60 with up to four lesions will receive thermotherapy and be monitored for 90 days. …

This early-stage study tests a new treatment called CABA-201 for people with systemic sclerosis (scleroderma), a disease that causes hardening of the skin and can damage organs. The treatment uses a patient's own immune cells, modified to target and destroy faulty B cells that dr…

This study looks at how long adults with plaque psoriasis and a common liver condition called MASLD (fatty liver disease) continue taking the drug secukinumab. Researchers will review medical records from several Spanish hospitals to track treatment duration and changes in liver …

This early-phase study tests a new treatment called BEN301, which uses specially engineered immune cells (CAR-Tregs) to calm overactive immune responses in people with autoimmune diseases like scleroderma, rheumatoid arthritis, lupus, and inflammatory muscle disease. The trial wi…

This study tests an experimental drug called SAR445399 in 144 adults with moderate to severe hidradenitis suppurativa (HS), a painful skin condition that causes abscesses and tunnels under the skin. Participants will receive one of two doses of the drug or a placebo for 32 weeks.…

This study tests whether adding an experimental drug (CDX-1140) to a standard immunotherapy (cemiplimab) before surgery can shrink advanced head and neck cancers more than the immunotherapy alone. About 44 people with stage III-IV head and neck cancer will receive either the comb…

This study is testing whether giving lower, less frequent doses of the cancer drug atezolizumab can still keep enough drug in the blood to fight cancer. About 30 adults with certain advanced cancers (like lung cancer or melanoma) will start with standard doses, then switch to a l…

This phase II trial tests whether a combination of amivantamab and hyaluronidase works as well as cetuximab for treating skin squamous cell carcinoma that has come back or spread. The study enrolls 86 immunocompromised participants, including organ transplant recipients. The goal…

This trial is testing whether an experimental biologic called IBI3027 works as well as the approved drug dupilumab for people with moderate-to-severe atopic dermatitis (eczema). About 520 adults will be randomly assigned to receive either IBI3027 or dupilumab as a subcutaneous in…

This study looks at how safe and effective Takhzyro is for teenagers and adults with hereditary angioedema (HAE) in everyday medical care in South Korea. HAE is a rare condition that causes sudden swelling under the skin or inside the body. The study will track side effects and h…

This study tests two types of engineered immune cells (CAR T cells) in 40 adults with active pemphigus vulgaris, a painful blistering skin condition. The cells are designed to target and reduce the faulty immune cells that attack the skin. The main goal is to check safety and fin…

This phase 3 trial compares a new injectable drug, GS101, to the established treatment Dupixent for adults with moderate-to-severe atopic dermatitis (eczema). About 572 participants will receive either GS101 or Dupixent every other week for a year. The main goal is to see if GS10…

This study tests a one-time treatment called CABA-201, made from a patient's own immune cells, for people with active inflammatory muscle diseases like dermatomyositis. The therapy aims to reset the immune system by targeting and removing certain immune cells. Researchers will ch…

This study tests whether an investigational drug called tilrekimig, given as injections alongside medicated creams or ointments, can improve moderate-to-severe eczema (atopic dermatitis) in people aged 12 and older. Participants will be randomly assigned to receive either tilreki…

This phase 3 trial tests whether a cream called SD-101 can help close wounds in children with epidermolysis bullosa (EB), a condition that causes fragile, blistering skin. About 80 children aged 1 month to 12 years will apply the cream or a placebo to their whole body for 2 month…

This study tests an oral medication called remibrutinib for adults with moderate-to-severe papulopustular rosacea, a skin condition causing red bumps and pustules on the face. The drug works by blocking a protein involved in inflammation. Researchers will measure whether it reduc…

This Phase 2 study tests brivekimig, an injected drug, in 208 people with moderate to severe hidradenitis suppurativa (HS), a chronic skin condition causing painful abscesses and tunnels. Participants receive different doses of brivekimig or a placebo for up to 48 weeks. The main…

This phase II trial is testing whether the combination of cabozantinib (a targeted therapy) and nivolumab (an immunotherapy) can shrink or stabilize advanced melanoma and head and neck cancers that have stopped responding to prior immunotherapy. Researchers are also checking if t…

This study looks at whether giving immunotherapy infusions in the morning improves outcomes for people with advanced melanoma. Researchers will compare morning versus afternoon/evening dosing in 108 participants. The goal is to see if aligning treatment with the body's natural im…

This study tests a combination of two immunotherapy drugs (nivolumab and ipilimumab) along with two anti-rejection medications (sirolimus and prednisone) in kidney transplant recipients who have advanced skin cancer that cannot be surgically removed or has spread. The goal is to …

This Phase 3 trial tests whether the oral drug nerandomilast can slow disease progression in adults with systemic sclerosis (scleroderma). About 448 participants will be randomly assigned to receive either nerandomilast or a placebo twice daily for up to 4 years. Researchers will…

This early trial tests whether a single infusion of anti-CD19 CAR T-cells can improve skin thickening and other symptoms in 6 adults with severe, treatment-resistant systemic sclerosis. Participants receive chemotherapy before the infusion and are monitored for 24 months. The stu…

This trial tests an experimental drug called DDY391 in about 220 adults with moderate to severe psoriatic arthritis, a condition that causes joint pain, swelling, and skin patches. Researchers want to see whether DDY391 can reduce joint symptoms better than a placebo and at what …

This trial is testing an investigational drug called GIA632 in people with moderate-to-severe cutaneous lichen planus, a skin condition that causes itchy, purple bumps. The study aims to see if GIA632 can clear or nearly clear the skin rash and reduce itching compared to a placeb…

This Phase 1 trial tests two experimental mRNA immunotherapies, mRNA-4106 and mRNA-4200, in about 42 people with advanced solid tumors. Unlike personalized cancer vaccines made from a patient's own tumor mutations, these are off-the-shelf therapies designed to target shared antig…

This first-in-human study tests the safety of a new drug called HBM7020. It will first be given to healthy volunteers at low doses, then to people with moderate to severe autoimmune diseases like lupus, rheumatoid arthritis, scleroderma, and Sjögren's disease. The goal is to see …

This study tests the long-term safety of deucravacitinib compared to ustekinumab in about 3,040 adults with moderate-to-severe plaque psoriasis who also have heart risk factors like smoking, high blood pressure, or diabetes. Participants will receive one of the two medications an…

This 24-month study tests the long-term safety and effectiveness of abrocitinib, a liquid oral medication, in children aged 2 and older with moderate-to-severe atopic dermatitis (eczema). About 500 participants will receive the drug, with or without topical creams. The goal is to…

This study tests a cream called delgocitinib for lichen sclerosus, a skin condition that causes itching, pain, and scarring in the genital area. About 652 adults with mild to severe disease will apply the cream twice daily for up to 52 weeks. Researchers will check if the cream i…

Researchers are testing an engineered interleukin-2 drug called MDNA11 in adults with advanced solid tumors. The trial gives MDNA11 alone or with pembrolizumab, an immune checkpoint inhibitor, to see which doses are safe and how the body processes the drug. It also looks for earl…

This study tests a medicated foam called roflumilast applied daily to hidradenitis suppurativa (HS) lesions for 16 weeks. It includes adolescents and adults with mild to moderate HS (Hurley stage I or II) who have 4 to 10 painful lumps or abscesses but no draining tunnels. The ma…

This study tests an experimental drug called GIA632 in 210 adults with non-segmental vitiligo, a condition that causes white patches on the skin. The goal is to see if the drug can safely restore skin color and to find the best dose for future studies. Participants will receive e…

This study is for people with moderate-to-severe eczema who have already completed a previous APG777 trial. It aims to see if APG777 is safe and works well over a longer period. Participants will receive injections of the drug every 12 or 24 weeks and be monitored for side effect…

This phase 3 study tests the long-term safety and effectiveness of remibrutinib, an oral drug, in 710 adults with moderate to severe hidradenitis suppurativa (HS), a chronic skin condition causing painful abscesses. Participants have already completed a prior remibrutinib study. …

This trial tests whether an experimental ointment called XJH05 can improve symptoms of plaque psoriasis, the most common form of the skin condition. The study enrolls a small group of adults with mild-to-moderate plaque psoriasis who apply the ointment twice daily for four weeks.…

This study tests the drug dupilumab (Dupixent) in 18 children aged 6 months to 18 years with prurigo nodularis, a condition causing very itchy skin bumps. The main goals are to measure how the drug moves through the body and to check for side effects. Participants receive injecti…

This study is for people with high-risk melanoma who have tiny bits of tumor DNA still in their blood after surgery. It compares a two-drug immunotherapy combo against a single drug to see which better clears these hidden cancer cells. About 54 participants will be randomly assig…

Researchers are testing a treatment plan that uses two drugs, remibrutinib and omalizumab, in adults with chronic spontaneous urticaria whose hives and itching are not controlled by standard antihistamines. The study follows about 382 adults across multiple centers worldwide. The…

This study tests a new drug, [212Pb]VMT01, that delivers a tiny dose of radiation directly to melanoma cells. It is being tested alone or with the immunotherapy nivolumab in 300 people with advanced melanoma that has worsened after prior treatment. The goal is to find safe doses …

This early-stage study tests a new medicine called PF-08046033 in adults with advanced lung, esophageal, or skin cancers that have spread or can't be removed. The main goal is to check safety and find the right dose. Researchers will also look for early signs that the drug may he…

This study looks at whether getting standard immunotherapy in the morning (before 11 am) or afternoon (after 12 pm) changes how well it fights advanced or metastatic solid tumors. Researchers think the body's internal clock (circadian rhythm) might affect immune activity. About 1…

This trial is testing an investigational drug called ARV-6723, given as a pill, in people with advanced solid tumors. The drug is designed to help the immune system recognize and attack cancer cells. The study will test ARV-6723 alone and in combination with pembrolizumab, an imm…

Researchers are testing whether the immunotherapy drug cemiplimab can be combined with a short, intense radiation schedule called Quad Shot in elderly or frail patients with locally advanced skin cancer of the head and neck. The study enrolls about 25 people who have not had prio…

This phase 2 trial tests whether a topical cream containing ruxolitinib (OPZELURA) can completely heal painful ulcers in adults with pyoderma gangrenosum, a chronic inflammatory skin condition. About 12 participants will apply the cream twice daily for 24 weeks while continuing s…

This study follows 40 people who received Miltenyi CAR T cell therapy at least one year ago for cancers like melanoma, lymphoma, or leukemia. Researchers will track side effects, cancer return, and overall health for years. The goal is to understand the long-term safety and effec…

This early-stage trial tests a cream called ruxolitinib on people with hidradenitis suppurativa, a condition causing painful lumps under the skin. The study includes 24 adults and teens and focuses on safety and how much of the drug gets into the body. Participants apply the crea…

This study tests an oral drug called povorcitinib in 40 adolescents aged 12 to 17 with moderate to severe hidradenitis suppurativa (HS), a chronic skin condition causing painful boils and tunnels. Over 54 weeks, researchers will check the drug's safety, how the body processes it,…

This study tests a new drug called BNT326, given alone or with other cancer immunotherapies, in about 980 adults with advanced solid tumors that have spread or come back after prior treatment. The goal is to find the best dose and see if it is safe and effective. It is an early-s…

This study tests a gel called EscharEx, made from pineapple enzymes, to remove dead tissue from hard-to-heal leg ulcers. About 216 adults with venous leg ulcers will receive either the active gel or a placebo. The goal is to see if the gel safely and effectively cleans the wound …

This early-stage trial tests an experimental drug called INCA036873 in about 280 adults with advanced solid tumors or certain blood cancers that have worsened after standard treatments. The main goal is to check safety and find the right dose. Participants receive the drug throug…

This study tests a cream called ruxolitinib in children aged 6 to 12 with nonsegmental vitiligo, a condition that causes white patches on the skin. The cream is applied twice daily to affected areas. The goal is to see if it can safely restore skin color. About 250 children will …

This study offers children aged 2 to 11 with hereditary angioedema (HAE) continued access to garadacimab, a lab-made antibody that helps prevent sudden, painful swelling attacks. Participants must have completed a prior study and shown good response with few or no attacks. The go…

This early-stage trial tests a new drug called TEV-53408 in 38 adults with vitiligo. The main goal is to see if the drug is safe when given as a shot under the skin. Researchers will also look for early signs that it might help bring back skin color. The study lasts 84 weeks, inc…

This early-phase trial tests a new drug called PRO-203, given as a single shot under the skin. First, healthy volunteers will check safety; then, people with systemic sclerosis (a rare autoimmune disease that hardens skin and organs) will receive the drug. The main goal is to see…

This study offers continued treatment with povorcitinib for up to 600 adults with hidradenitis suppurativa who completed a prior trial and saw benefit. The main goal is to track side effects over time, with a secondary focus on reducing skin abscesses, nodules, and tunnels. Parti…

This trial is testing an experimental drug called 611 in children aged 2 to 12 with moderate-to-severe atopic dermatitis, a common skin condition that causes itchy, inflamed skin. The drug is designed to block a specific immune signal that drives the inflammation behind eczema. T…

This study tests a new drug, AZD6750, that helps the immune system fight cancer. It is for adults with advanced solid tumors like melanoma, lung, or breast cancer that have not responded to other treatments. The goal is to find the safest dose and see if it shrinks tumors when us…

This study tests an experimental drug called LY4005130 in 60 adults with non-segmental vitiligo, a condition that causes white patches on the skin. Participants receive either the drug or a placebo by IV every few weeks for 24 weeks. The goal is to see if the drug can reduce the …

This study is the first time REGN20423 is being tested in humans. It will enroll 144 adults, first healthy volunteers and then people with atopic dermatitis (eczema). The goal is to check safety, side effects, how the drug moves through the body, and whether it helps eczema sympt…

This study tests an investigational drug called barzolvolimab in 240 adults who get hives from cold temperatures or from scratching their skin, and whose symptoms are not controlled by standard allergy pills. Participants receive either the drug or a placebo injection, and doctor…

This phase 2 trial tests whether a combination of three drugs—fianlimab, cemiplimab, and ipilimumab—can safely shrink tumors in people with advanced melanoma that no longer responds to standard PD-1 therapy. The study enrolls 88 adults with locally advanced or metastatic melanoma…

This study tests whether a new combination of drugs (fianlimab and cemiplimab) works better than an already approved treatment (Opdualag) for people with advanced melanoma that cannot be removed by surgery or has spread. About 560 adults with previously untreated melanoma will re…

Researchers are testing whether denifanstat, an experimental oral drug taken once daily, can reduce acne lesions and clear skin in people aged 12 and older with moderate to severe acne. The trial compares denifanstat with a placebo pill in about 800 participants over 12 weeks. A …

This large study in Fiji tests whether a new combination of drugs (moxidectin plus two others) can safely treat three common parasitic infections: lymphatic filariasis, scabies, and strongyloidiasis. About 5,100 people will receive either the new combo or the standard treatment o…

This study tests whether adding dupilumab to standard treatment can help people with hypereosinophilic syndrome (HES) who still have symptoms despite current biologic therapy. About 30 adults will receive dupilumab injections for up to 48 weeks while continuing their usual medica…

This study tests whether adding an experimental drug (EIK1001) to standard immunotherapy (pembrolizumab) helps people with advanced melanoma live longer without their cancer growing. About 740 adults with stage 3 or 4 melanoma that cannot be removed by surgery will receive either…

This study looks at the long-term safety and effectiveness of the drug afimkibart for people with atopic dermatitis (eczema) who have already taken it in earlier studies. About 120 adults will be followed to see how well the drug controls their eczema over time and what side effe…

This early-phase trial is testing a new treatment for autoimmune disorders like lupus and scleroderma. It combines specially engineered natural killer cells (AD-PluReceptor) with a drug called tafasitamab and chemotherapy to try to control the disease. The study will enroll 47 pe…

This study tests whether adding the drug tarlatamab to standard radiation therapy is safe for people with cancers that have a protein called DLL3, including melanoma, lung cancer, and glioblastoma. About 30 adults with advanced or returning cancers will receive tarlatamab infusio…

This expanded access program provides bitopertin (DISC-1459) to patients aged 12 and older with erythropoietic protoporphyria (EPP) or X-linked protoporphyria (XLP) who have no satisfactory treatment options in the US. The goal is to offer access and gather safety information. Pa…

This Phase 3 trial is testing whether an experimental biologic called tilrekimig can reduce the severity of moderate-to-severe atopic dermatitis (eczema) in people aged 12 and older. Participants will receive either tilrekimig, an existing treatment (dupilumab), or a placebo for …

This early-phase trial is testing a new drug called IACS-6274, either alone or combined with other cancer drugs, in 54 adults with advanced solid tumors (such as melanoma, ovarian, or head and neck cancers). The main goal is to find the safest dose and understand side effects. Th…

Researchers are testing an experimental drug called BCA101 in people with advanced solid tumors that are driven by EGFR, a protein that helps cancer cells grow. BCA101 is a dual-targeting antibody designed to block both EGFR and TGF-beta, a signal that can suppress the immune sys…

This study tests an experimental treatment called OBX-115 for people with advanced melanoma or non-small cell lung cancer that has spread or stopped responding to standard therapy. OBX-115 uses a patient's own immune cells (tumor-infiltrating lymphocytes) that are modified in the…

This study tests an experimental drug called MTX-474 in 85 people with diffuse cutaneous systemic sclerosis, a condition that causes skin thickening and organ damage. Participants will receive either MTX-474 or a placebo for 24 weeks to see if the drug safely reduces skin thickne…

This study is for people who have both an autoimmune disease (like rheumatoid arthritis, lupus, or multiple sclerosis) and an advanced cancer that has spread or cannot be removed by surgery. It tests the safety and effectiveness of the immunotherapy drug nivolumab, given alone or…

This early-stage trial is testing a new form of fenretinide (a vitamin A-like drug) given by IV for people with T-cell non-Hodgkin lymphoma that has come back or stopped responding to treatment. The study has two parts: first, finding the safest dose in small groups of patients, …

This study is testing a special soft cast for people with diabetic foot ulcers. The cast is a multi-layer wrap that cushions the foot and leg to help the wound heal. Researchers want to see if it works well, is comfortable, and safe. About 100 adults with diabetic foot ulcers wil…

This study tests a gel device called Multi-Gyn FemiTotal in 80 women with bacterial vaginosis or vaginal yeast infections. Participants use the gel for 7 days, and if symptoms clear, they are followed for 4 months to see if the infection returns. The goal is to see if the gel can…

This trial is testing an experimental therapy called STX-003, which uses mRNA to produce a protein that may help the immune system fight cancer. It is given intravenously, either alone or with the immunotherapy drug pembrolizumab (Keytruda). The study involves adults with advance…

This study offers continued access to anifrolumab (Saphnelo) for people with systemic lupus erythematosus, systemic sclerosis, or myopathies who completed a prior anifrolumab trial and are still benefiting from the drug. Participants receive the same treatment as before, while re…

This study tests whether adding calcipotriene to the standard cream fluorouracil works better for people with multiple actinic keratoses (precancerous skin spots). Thirty adults will apply either fluorouracil alone for 2-3 weeks or a combination cream for just 4 days. Researchers…

This study tests a new drug called Bmab1800 to see if it works like the approved drug Keytruda in people with stage IIB, IIC, or III melanoma after their tumor has been removed by surgery. About 138 adults will get either Bmab1800 or Keytruda, and researchers will compare how the…

This early-stage trial tests an oral drug called QX-4533 in healthy volunteers and in people with moderate-to-severe atopic dermatitis, a common type of eczema. The main goal is to check the drug's safety and how the body processes it, while also looking for early signs that it m…

This early-stage trial tests a new drug called TOP-N53, applied directly to finger ulcers in people with systemic sclerosis (scleroderma). The main goal is to check safety and see if it improves pain and blood flow. Fifteen participants will receive either the drug or a placebo o…

This study tests a daily pill called upadacitinib for people with severe forms of lichen planus, a skin disease causing painful mouth sores or hair loss. About 56 adults will receive either the drug or a placebo for 16 weeks to see if it reduces symptoms. The goal is to control t…

This study tests whether special wraps made from human placental membrane can help heal diabetic foot ulcers and venous leg ulcers that won't close on their own. About 50 adults with diabetes or venous disease will receive weekly applications of one of four placental membrane pro…

This study tests whether early use of the drug bimekizumab can delay or prevent chronic inflammation in people with mild plaque psoriasis. 40 adults with recent-onset or long-standing mild psoriasis will receive either bimekizumab injections or a topical steroid cream. The goal i…

This trial tests whether a new skin graft substitute (CAMP) plus standard wound care helps wounds heal faster after Mohs surgery for skin cancer compared to standard care alone. About 160 adults who have had Mohs surgery for a skin cancer will be randomly assigned to receive eith…

This study follows 700 adults with moderate-to-severe plaque psoriasis who are already prescribed risankizumab by their doctor. Researchers will track changes in quality of life, including skin symptoms and daily impacts, over up to 2.5 years. The goal is to see how well the drug…

Researchers are testing extracorporeal photopheresis (ECP), a procedure that treats a patient's blood with light and a drug called methoxsalen, in adults with diffuse cutaneous systemic sclerosis. The trial aims to see whether ECP is feasible and safe, and whether it can improve …

This phase 2 trial is testing an experimental drug called patritumab deruxtecan (HER3-DXd) in 740 people with advanced solid tumors, including melanoma, lung, breast, and other cancers. The drug is given by IV every three weeks. The main goal is to see if the drug shrinks tumors.…

This trial tests whether a daily application of roflumilast 0.3% cream can improve both chronic plaque psoriasis and moderate-to-severe nail psoriasis. People aged 12 and older with stable disease for at least 6 months apply the cream to affected nails and plaques daily for 24 we…

This study compares giving oral isotretinoin (a strong acne medication) right away versus the usual antibiotics for moderate acne in people with darker skin (Fitzpatrick types IV-VI). The goal is to see if early use of isotretinoin reduces acne-related dark spots better than stan…

This study tests a cream called delgocitinib for people with mild to severe palmoplantar pustulosis, a skin condition causing painful pus-filled blisters on hands and feet. About 135 adults will apply the cream twice daily for 16 weeks. The main goal is to see if the cream reduce…

This phase 2 trial is investigating whether giving immunotherapy before surgery for advanced melanoma (stage IIIB to IV M1a) can maintain survival while allowing patients to skip the usual adjuvant therapy after surgery. Participants are randomly assigned to receive either two in…

This first-in-human trial evaluates BYN-001, an antibody designed to block IL-25, a protein linked to atopic dermatitis (eczema). The study first tests the drug in healthy volunteers to assess safety and how it moves through the body, then in people with moderate to severe eczema…

This early-stage trial is testing an experimental drug called KK2223 in 72 adults with T-cell lymphoma (a type of blood cancer) that has returned or not responded to prior treatments. The main goals are to check the drug's safety, find the best dose, and see how the body processe…

This study tests a drug called zasocitinib in adults with nonsegmental vitiligo, an autoimmune condition that causes white patches on the skin. About 200 participants will take either the drug or a placebo for up to a year. The main goal is to see if the drug can improve skin col…

This phase 3 study tests an intravenous C1 esterase inhibitor (C1-INH) in people with hereditary angioedema (HAE) to treat acute attacks and prevent attacks before medical procedures. About 124 participants, aged 2 and older, will receive either the drug or a placebo. The main go…

Researchers are testing whether mycophenolate mofetil can slow early lung scarring in people with systemic sclerosis, a disease that hardens skin and can damage internal organs. The trial enrolls 35 adults whose scans show mild lung fibrosis but who have not yet developed serious…

Researchers are testing a combination treatment for melanoma that has spread to the liver and stopped responding to standard therapy. Participants receive cryoablation, which freezes liver tumors, along with immunotherapy and chemotherapy delivered directly into the liver's blood…

This study tests a new drug called remibrutinib (a tablet) against a placebo in 44 adults with chronic hives (either spontaneous or triggered by things like pressure or cold). The goal is to see if it reduces symptoms like itching and burning, and how it works in the body. Partic…

This phase 2 trial tests whether sildenafil, a drug used for pulmonary hypertension, can help people with scleroderma who have mildly elevated lung pressures. Thirty participants will receive either sildenafil or a placebo for 4 months. The main goal is to see if the drug improve…

This study looks at how well guselkumab works for people with moderate to severe psoriasis who switch from ustekinumab (or its biosimilar) in a real-world setting. Researchers will track skin clearance using the PASI score at various time points over a year. The goal is to see if…

This study tests whether adding a personalized mRNA vaccine (V940) to standard immunotherapy (pembrolizumab) can stop advanced melanoma from growing or spreading. About 160 people with stage III or IV melanoma that cannot be removed by surgery will receive either the vaccine plus…

This study tests a lotion called QRX003 in people with Netherton Syndrome, a rare genetic skin condition. About 16 participants aged 4 and older will apply the lotion twice daily for 12 weeks. Researchers will check if it improves skin appearance and reduces itching.

This study watches 200 adults with moderate-to-severe plaque psoriasis who have never taken a biologic before. They are starting treatment with guselkumab, and researchers will track how many continue the drug for two years. The goal is to see how well people stick with this trea…

This Phase 1 trial tests a single oral dose of HRS-4139, an experimental drug for psoriasis, in healthy adults aged 18 to 55. Researchers measure how the body absorbs and processes the drug, and watch for any side effects. The goal is to establish a safe dose for future studies i…

This study tests whether adding a prebiotic-rich diet to standard immunotherapy before surgery can improve immune response in people with melanoma. About 35 adults with resectable melanoma will receive prebiotic snack packs and diet counseling alongside their usual treatment. The…

This study tests a combination of two drugs—pembrolizumab (an immunotherapy that helps the immune system fight cancer) and lutetium Lu 177 dotatate (a radioactive drug that kills cancer cells)—in 18 adults with Merkel cell carcinoma. The goal is to see if the combination can shri…

This study tests whether abrocitinib, a liquid medicine, can improve moderate-to-severe eczema in children aged 6 to 12. About 150 kids will be randomly assigned to receive either the drug or a placebo for 16 weeks. The goal is to see if the medicine clears the skin and reduces i…

This study tests anifrolumab, a weekly injection, for adults with moderate to severe polymyositis or dermatomyositis—rare diseases that cause muscle weakness and inflammation. About 240 participants will receive either anifrolumab or a placebo added to their usual care for 52 wee…

This Phase 3 trial is testing whether a powerful combination of two treatments works better than standard immunotherapy alone for people with advanced melanoma that has not been treated yet. The experimental approach uses lifileucel, a personalized therapy made from a patient's o…

This study tests an oral drug called NEO212 in people with specific brain tumors (astrocytoma, glioblastoma) or cancers that have spread to the brain. The goal is to find the safest dose and see if it helps control tumor growth. About 134 adults will take NEO212 alone or with sta…

This trial tests an investigational drug called ORKA-002 in adults with moderate-to-severe hidradenitis suppurativa, a chronic skin condition that causes painful lumps and tunnels under the skin. Participants receive either ORKA-002 or a placebo by injection, and researchers meas…

This study is testing the long-term safety and effectiveness of a drug called ORKA-001 for people with moderate-to-severe plaque psoriasis. It is an open-label extension, meaning everyone gets the drug, and it includes 240 adults who already completed a previous trial with ORKA-0…

This early-phase trial will test BCT301, a type of immune cell made from stem cells, in 10 people with severe autoimmune diseases like lupus and scleroderma. Participants receive a single infusion of these cells after a short course of chemotherapy. The main goal is to check safe…

This trial tests a new drug called N17350, a modified enzyme injected directly into tumors, in adults with advanced solid tumors that have not responded to standard treatments. The study aims to find the safest and most effective dose, and to see if the drug can shrink or stop tu…

Researchers are testing a new hormonal pill for moderate acne in women. The pill combines an antiandrogenic progestogen with a lower dose of estrogen. In this Phase III trial, about 530 participants will take either the experimental pill or a placebo for six months while using st…

This study tests an experimental drug called ponesimod in 300 adults with moderate-to-severe plaque psoriasis. The goal is to see if it is safe and helps control the disease. Participants take the drug and are monitored for side effects and skin improvement.

This early-phase study tests a new radioactive drug, 225Ac-ETN029, in 116 adults with advanced DLL3-positive cancers like small cell lung cancer or neuroendocrine tumors. The main goal is to check safety and find the right dose, while also seeing if the drug can shrink tumors. Pa…

Researchers are testing a topical filmogel device called URGO MICKAEL on mild to moderate toenail fungus. About 54 adults with one or two damaged big toenails apply the device daily for up to six months. The study measures whether fungal cultures from the treated nail turn negati…

This Phase 3 trial tests an oral drug called deucrictibant in adults with acquired angioedema due to C1 inhibitor deficiency, a rare condition causing sudden, painful swelling attacks. The study has three parts: one to see if a daily extended-release tablet can prevent attacks, a…

This early-phase trial tests the safety of CRD3874-SI, a drug that activates the STING pathway to boost the immune system against cancer. About 81 adults with advanced solid tumors (sarcoma, Merkel cell carcinoma, and others) will receive weekly IV infusions at increasing doses. …

This Phase 3 trial tests an oral drug called KP-001 in 150 people aged 2 and older with venous malformations, lymphatic malformations, or KTS/CLOVES syndrome. Participants receive either KP-001 or a placebo for 24 weeks, then everyone gets the drug for another 28 weeks. The goal …

Researchers compare two drugs, baricitinib and adalimumab, in people with intestinal Behçet's syndrome that has not improved with standard treatments. Participants receive one of the drugs for six months while continuing their existing steroids or immune-modulating medicines. The…

This study tests personalized phage therapy in people with serious infections that have not responded to antibiotics or surgery. Researchers will collect data before, during, and after treatment to see how safe and effective phage therapy is, and how it affects different body sit…

This early-stage trial tests whether injecting gold nanoparticles into tumors, followed by radiation and an immunotherapy drug, is safe for people with advanced melanoma. Only 6 participants will be enrolled. The goal is to check for side effects, not to see if the treatment work…

This early-stage trial tests whether a stool transplant (FMT) can help cancer patients who develop severe diarrhea or colon inflammation from immune-checkpoint inhibitor drugs. About 40 patients with various cancers will receive the transplant via colonoscopy. The main goal is to…

This early-phase trial is testing an injection called GT719 in 10 adults with moderate to severe autoimmune diseases that haven't responded to other treatments. The main goal is to check safety and find the right dose. Researchers will also look for signs that the therapy might h…

This study tests two daily doses (50 mg and 100 mg) of the medicine ritlecitinib in about 550 people aged 12 and older with severe alopecia areata, a condition causing significant hair loss on the scalp and body. The 50 mg dose is already approved, and researchers want to see if …

This study tests whether baricitinib, a drug already approved for arthritis, can help people with Kohlmeier-Degos (KD) disease that affects the brain and spine. KD causes inflammation and blood clots that damage small blood vessels, and there is currently no treatment. The trial …

This study tests a new drug called AU-007 in people with advanced solid tumors that have spread or cannot be removed by surgery. The drug is designed to help the immune system fight cancer. About 159 participants will receive AU-007 alone or with other medicines to find the safes…

This early-stage study tests a new drug called N-3C01, given alone or with an immunotherapy, in people with advanced solid tumors that have spread or cannot be removed. The main goals are to check safety, find the right dose, and see if the combination shrinks tumors. About 114 a…

This trial tests whether the drug sebetralstat can prevent swelling attacks in people with hereditary angioedema (HAE) when taken before a medical procedure. Participants aged 12 and older with HAE type I or II will take sebetralstat just before their scheduled procedure. The mai…

This study tests the immunotherapy drug atezolizumab in 200 people with advanced solid tumors (breast, lung, GI, and others). Researchers use each person's tumor DNA to see if it predicts a response. Participants get the same dose every 3 weeks. The goal is to see if DNA analysis…

This early-stage trial is testing a new drug called BL-M14D1 in about 120 people with advanced small cell lung cancer or other neuroendocrine cancers that have spread or cannot be removed. The drug works by homing in on a protein called DLL3 found on these cancer cells and delive…

This phase 3 trial tests whether injecting the drug cemiplimab directly into early-stage skin cancer tumors can work as well as surgery. About 369 people with small tumors on the head, neck, hand, or shin will be randomly assigned to get either the injections or standard surgery.…

This Phase 3 trial tests a drug called dazukibart in people with active dermatomyositis or polymyositis, rare diseases that cause muscle weakness and inflammation. About 318 adults will receive either the drug or a placebo by IV every 4 weeks for 48 weeks. The study aims to see i…

Researchers test whether halving the bleomycin dose in electrochemotherapy controls skin tumors as well as the standard dose. Electrochemotherapy gives chemotherapy followed by brief electrical pulses that help the drug enter tumor cells. Adults with cutaneous or subcutaneous can…

This study tests an experimental drug called CGT9486 (bezuclastinib) in people with advanced systemic mastocytosis, a rare and serious blood disorder. The drug aims to control the disease by blocking a key protein that drives abnormal mast cell growth. About 140 adults with aggre…

This study tests whether adding a fecal microbiota transplant called LND101 to standard immunotherapy can help stop advanced melanoma from growing or spreading. About 128 people with stage IV or unresectable melanoma will receive either immunotherapy alone or immunotherapy plus L…

This study tests whether injecting sodium thiosulfate directly into abnormal calcium deposits can shrink them and reduce pain. It includes people with three rare conditions: systemic sclerosis, dermatomyositis, and a genetic disorder called iPPSD2. Participants receive up to 11 i…

Researchers are testing an oral drug called PORT-77 in people with erythropoietic protoporphyria (EPP) and X-linked protoporphyria (XLP), rare conditions that cause severe pain after sunlight exposure. The trial enrolls about 225 adults and adolescents aged 12 and older. It compa…

This phase 2 trial compares two treatment combinations for people with BRAF-V600 mutant melanoma that has spread to the brain. One group gets a targeted therapy (encorafenib and binimetinib) plus an immunotherapy (nivolumab), while the other gets two immunotherapies (ipilimumab a…

This early-stage trial is testing an experimental drug called EVOLVE104 in people with advanced bladder cancer or several types of squamous cell carcinoma (lung, esophagus, skin, and others). The study aims to find a safe dose and see if the drug can shrink tumors. It is for pati…

This study tests a cream called ruxolitinib in 180 children with nonsegmental vitiligo, a condition that causes white patches on the skin. The goal is to see if the cream can safely bring back color, especially on the face. Participants will apply the cream daily for several mont…

This study tests an experimental drug called rezpegaldesleukin (NKTR-358) for people aged 12 and older with moderate-to-severe atopic dermatitis, a type of eczema. Participants receive either the drug or a placebo as a shot under the skin. The goal is to see if the drug can clear…

This study tests a new treatment plan for people with a rare and aggressive blood cancer called BPDCN. The plan combines two targeted drugs (tagraxofusp and venetoclax) with standard chemotherapy to kill cancer cells. The goal is to see if this combination can control the disease…

This study tests a device that moves a small piece of shinbone to improve blood flow and help heal chronic foot ulcers in people with diabetes. One hundred adults with stubborn ulcers that haven't healed after 12 weeks will be enrolled. The goal is to see if this procedure, added…

This study tests a standardized, optimized approach to cord blood transplantation for adults with high-risk blood cancers like leukemia and lymphoma. The method includes specific chemotherapy, radiation, and stem cell dosing, followed by careful monitoring. Researchers hope to im…

This study tests a new radiation method called minibeam therapy for people with skin or soft tissue tumors that have come back or spread. The treatment uses a special device to split a wide radiation beam into many tiny beams, which may reduce damage to healthy tissue. The goal i…

This study tests a new drug called mibavademab for people with generalized lipodystrophy, a rare condition where the body lacks fat tissue. The goal is to see if the drug can improve blood sugar, lower blood fats, and reduce liver fat. About 28 children and adults will take part …

This phase 3 trial is testing an experimental drug called ADX-324 in 90 adults with hereditary angioedema (HAE) types 1 or 2. HAE causes sudden, painful swelling in the body. ADX-324 uses a technology called siRNA to lower levels of a protein involved in triggering these attacks.…

This study is testing whether Botox injections can reduce inflammation in people with hidradenitis suppurativa (HS), a chronic skin condition that causes painful lumps. Researchers believe that blocking certain nerve signals may calm the immune response. The study will enroll 20 …

This early-stage study tests a new treatment called ALLO-329 for people with lupus, myositis, or scleroderma. The therapy uses specially engineered immune cells from a donor to target and calm the overactive immune system. The main goals are to check safety and see if it can impr…

This phase 2 trial tests an injection called SHR-1139 in 10 adults with ulcerative pyoderma gangrenosum, a rare skin condition that causes painful, open sores. The main goal is to see if the drug can completely close the target ulcer within 12 weeks. Researchers will also check f…

This phase 2 trial tests a drug called PTX-100 in 115 adults with relapsed or refractory cutaneous T-cell lymphoma (CTCL), a rare type of skin cancer. Participants receive PTX-100 by IV infusion over several cycles. The goal is to see if the drug can shrink or eliminate tumors an…

This phase 3 trial is testing an experimental daily capsule called TQH3906 in adults with moderate to severe plaque psoriasis. The drug works by blocking a key immune pathway involved in skin inflammation. Researchers are comparing TQH3906 against a placebo and an approved treatm…

This study tests a drug called secukinumab in Chinese adults with moderate to severe hidradenitis suppurativa, a painful skin condition that causes boils and tunnels under the skin. The goal is to see if the drug reduces skin lesions and prevents flare-ups over 16 weeks. About 36…

This study looks at the long-term safety and effectiveness of belimumab in adults with lung scarring (interstitial lung disease) caused by systemic sclerosis or other connective tissue diseases. About 514 people who completed earlier trials will receive belimumab for up to severa…

This study tests whether shining a special low-level laser on chronic leg ulcers can help them heal faster. 96 adults with venous leg ulcers will receive either real laser treatment plus standard compression, or a sham laser plus compression, twice a week for 16 weeks. The goal i…

This early-stage study tests a new drug called SAR448501 (DR-0201) in 62 adults with lupus or rheumatoid arthritis. The drug is a bispecific antibody designed to target the immune system. The main goal is to check safety and find the right dose, not yet to prove it works. Partici…

This phase 3 trial tests whether zasocitinib, an oral medication, can safely and effectively treat moderate-to-severe plaque psoriasis in children and teens aged 4 to 17. The study involves 110 participants and lasts up to 4 years. In the first part, some receive the drug and oth…

This study tests a wearable device called Tight Alright that measures pressure under compression bandages for venous leg ulcers. Standard compression therapy is effective but hard to get right without feedback. The device sends pressure data to a phone app, helping clinicians and…

This study tests whether baricitinib, a daily pill, can safely regrow hair in children aged 6 to 17 with severe alopecia areata (patchy hair loss). About 595 kids will receive either the drug or a placebo for 36 weeks, then all can get the drug for up to 2 years. The goal is to s…

This study tests whether a cream containing ruxolitinib (Opzelura) combined with corticosteroid injections or pills can improve facial vitiligo. It includes people aged 12 and older with active, non-segmental vitiligo affecting the face. Participants use the cream twice daily and…

This phase 3 trial tests an experimental drug called SHR-1819 in about 200 teenagers aged 12 to 17 with moderate-to-severe atopic dermatitis (eczema). Participants receive either the drug or a placebo injection. The study measures how well the drug clears skin rashes and reduces …

This trial tests whether combining bexmarilimab with nivolumab can help people whose cancers no longer respond to immunotherapy. It focuses on two cancers: non-small cell lung cancer and melanoma. The study first finds the safest dose of bexmarilimab to give with a fixed dose of …

This study tests an experimental drug called rezpegaldesleukin (NKTR-358) for people aged 12 and older with moderate-to-severe atopic dermatitis, a type of eczema. Participants receive either the drug or a placebo as a shot under the skin. The goal is to see if the drug can clear…

This phase 3 trial tests whether belimumab (Benlysta) can stabilize or improve lung function in adults with interstitial lung disease caused by connective tissue diseases like rheumatoid arthritis or lupus. About 440 participants will receive either belimumab injections or a plac…

This study tests whether belimumab (Benlysta), a drug already used for lupus, can improve lung function and skin thickening in adults with scleroderma-related interstitial lung disease. About 300 participants will receive either belimumab or a placebo added to their standard care…

This study tests whether specially grown donor immune cells (called cytotoxic T lymphocytes) can safely and effectively control BK and JC virus infections in people with weakened immune systems, such as those with cancer, HIV, or organ transplants. About 100 participants will rec…

This trial asks whether adding a Mediterranean diet or a low-histamine diet to standard care can reduce disease activity and improve quality of life in teens aged 12-18 with chronic spontaneous urticaria (CSU), a condition causing persistent hives. Participants are randomly assig…

This study is testing whether adding the weight-loss drug tirzepatide to the standard psoriasis medication ixekizumab helps people with moderate-to-severe plaque psoriasis who are also overweight or obese. About 200 adults will receive tirzepatide injections for up to 12 months. …

This study is testing a device called the TrueLok Elevate that uses a technique called transverse bone transport to help heal chronic lower limb ulcers. The device is attached to the leg and slowly moves a piece of bone to stimulate blood flow and tissue healing. Researchers will…

This study tests two oral drugs, AMXT 1501 and DFMO, given alongside standard treatments for people with advanced solid tumors (breast cancer or melanoma) that have worsened after prior therapies. The goal is to find a safe dose and see if the combination helps shrink tumors or s…

This study is for people with hereditary angioedema (HAE) who have already completed a previous trial of the drug ADX-324. ADX-324 is an RNA-based medicine designed to lower a protein involved in swelling attacks. The goal is to see if long-term use is safe and can reduce the num…

This study tests whether adding a Mediterranean diet (rich in olive oil, nuts, fish, and limited red meat) improves psoriasis symptoms in 36 adults who are about to start biologic therapy (Anti-IL-17 or Anti-IL-23 drugs). Participants are randomly assigned to either follow the di…

This trial tests whether a radiofrequency device can reduce inflammatory acne lesions as effectively as a standard topical gel. About 60 adults with mild-to-moderate facial acne will be randomly assigned to receive either three radiofrequency sessions or daily application of a co…

This Phase 3 trial tests YCANTH, a topical solution containing cantharidin (a substance from blister beetles), against a placebo for treating common warts. About 300 people aged 2 and older with at least one wart on their body (excluding certain areas) will receive either the act…

This study tests an experimental drug called IDP-001 in people with advanced or metastatic solid tumors, including certain lung, head and neck, and other cancers. The trial has two phases: first to check safety and find the right dose, then to see if the drug can shrink tumors. A…

This early study tests whether taking capsules containing donor fecal bacteria can change the gut and skin bacteria of people with hidradenitis suppurativa (HS), a painful skin condition. Sixteen adults with HS will receive either the bacteria capsules or a placebo for three week…

This early-phase trial is testing whether a drug called camonsertib, combined with a precise type of radiation, can help control head and neck cancers that have come back or cannot be removed by surgery. About 39 adults with these cancers will receive the drug along with focused …

This study tests a daily pill called deucravacitinib in teenagers aged 12 to 18 with moderate to severe plaque psoriasis. About 366 participants will receive either the drug or a placebo. The main goals are to see if the drug improves skin clearance by at least 75% and reduces ov…

This trial tests an investigational cell therapy called FT839 in people with active autoimmune diseases, including ANCA-associated vasculitis, inflammatory myositis, rheumatoid arthritis, lupus, and systemic sclerosis. Participants receive FT839 as two intravenous infusions, some…

This study tests a drug called donidalorsen in 20 children aged 2 to 12 with hereditary angioedema (HAE), a condition that causes sudden, painful swelling. The goal is to see if the drug is safe and how it works in young bodies. Researchers will monitor side effects and measure h…

This study tests whether spesolimab, given as an infusion, can help close skin ulcers in adults with pyoderma gangrenosum, a rare inflammatory skin condition. About 90 participants will receive either spesolimab or a placebo, along with corticosteroids. The trial lasts about 1.5 …

This trial tests a two-part approach for viral warts: applying mild heat at 44°C to the largest wart and using a 3% hydrogen peroxide solution on all warts. The idea is that heating one lesion may rally the immune system to fight the virus elsewhere, while the peroxide works dire…

This phase II trial tests whether combining a targeted antibody drug (mogamulizumab) with a procedure that treats white blood cells with light (extracorporeal photopheresis) can better control erythrodermic cutaneous T-cell lymphoma, a rare skin cancer. About 34 adults with advan…

This study tests whether a vacuum dressing (negative pressure wound therapy) reduces infection compared to standard bandages after skin graft surgery for leg tumors. About 242 adults will be randomly assigned to one of the two dressings. The main goal is to see if the vacuum dres…

This study tests whether the drug ritlecitinib can prevent keloids from returning after surgical removal. Keloids are raised, often itchy scars that grow beyond the original wound. The trial will enroll 30 adults who will take a daily pill for 36 weeks. Researchers will measure k…

This program provides compassionate use of dupilumab (Dupixent) for patients with severe type 2 inflammatory disorders who have no other treatment options. It aims to offer access to this drug outside of a clinical trial. The program is already approved for marketing.

This early-phase trial tests siplizumab, a drug given as a shot under the skin, in 12 adults with moderate-to-severe hidradenitis suppurativa (painful boils) that hasn't improved with standard treatments. The main goal is to see if the drug safely reduces the number of inflamed l…

This trial tests whether QRX003, a lotion applied to the skin, can reduce the redness, scaling, and itch caused by Netherton syndrome, a rare genetic condition. Participants apply the lotion twice daily for 3 months and visit the clinic every 4 to 6 weeks for checkups. The study …

This trial tests whether QRX003 lotion, applied to the skin, can safely reduce the severity of Netherton syndrome, a rare genetic condition causing red, scaly skin and intense itching. Researchers will enroll about 20 people aged 14 and older who have the condition. Participants …

This study tests a combination of darolutamide, hormone therapy, and a lower dose of the chemotherapy drug docetaxel in men with metastatic hormone-sensitive prostate cancer. The goal is to see if this approach can keep PSA levels very low (below 0.2 ng/mL) at 24 weeks while redu…

This trial tests whether a daily oral capsule called 2LVERU can clear common, flat, or plantar warts caused by HPV. Researchers compare the capsule against a placebo in 162 people aged 3 and older over 6 months. The main question is whether warts disappear completely by the end o…

This trial investigates whether an oral medication called brepocitinib can safely reduce skin lesions in adults with cutaneous sarcoidosis, a condition where inflammation causes bumps and rashes on the skin. Participants will receive either brepocitinib or a placebo to compare ef…

This trial tests whether giving a single dose of acoziborole to people who test positive for sleeping sickness antibodies, but show no active infection, can stop the disease from spreading in a community. Researchers will screen entire villages and treat all seropositive individu…

This trial tests whether a silicone-based or a hydrocolloid patch placed under insulin pumps or glucose monitors can prevent contact dermatitis from coming back in children aged 2-18. Participants will use different patches and attend visits for skin exams, ultrasounds, and quest…

This trial tests whether an artificial intelligence app called PRESS AI can help nurses prevent pressure injuries (bedsores) in adult intensive care patients. The app supports nurses in assessing risk, staging wounds, and planning care. Researchers will compare the rate of new pr…

This trial tests whether removing and examining the sentinel lymph node—the first node a skin cancer might spread to—can catch metastasis earlier than standard monitoring. Half of the 142 participants with high-risk cutaneous squamous cell carcinoma will receive the biopsy plus s…

This study looks at teenagers aged 12 to 17 who have severe atopic dermatitis (eczema) with intense itching but only a mild to moderate rash. They are being treated with dupilumab (Dupixent), a standard medication. The goal is to see how well dupilumab controls itching, improves …

This trial tests an experimental drug called STAR0602, which is designed to help the immune system attack cancer cells. It is being studied in people with advanced solid tumors that have not responded to standard treatments. The drug is given alone or combined with chemotherapy, …

This study tests whether a computerized training program designed to improve response inhibition — the ability to stop an automatic action — can reduce symptoms in people with obsessive-compulsive disorder, trichotillomania (hair-pulling), or skin-picking disorder. Participants a…

This study tests whether reflectance confocal microscopy (RCM), a noninvasive imaging technique, can detect structural changes in the skin of people with moderate-to-severe atopic dermatitis (eczema) who are treated with nemolizumab. Nemolizumab is an antibody that blocks IL-31, …

This early study tests a new gene therapy gel called KB111 for Hailey-Hailey disease, a rare genetic condition that causes painful blisters and skin lesions. The gel uses a modified virus to deliver a working copy of the faulty gene directly to the skin. The trial enrolls about 7…

This trial tests whether a special dressing containing tocotrienols (a form of vitamin E) helps heal stage 1 and 2 pressure ulcers (bedsores) faster than standard care. About 114 adults with pressure ulcers will be randomly assigned to receive either the tocotrienol dressing or a…

This trial investigates whether two special wound dressings—one made from donated amniotic membrane and another from a synthetic material—can help heal diabetic foot ulcers and venous leg ulcers that have not responded to standard care. Adults aged 18 and older with these hard-to…

This study investigates whether a single infusion of a patient's own genetically modified immune cells (CD19 CAR-T cells) can safely control moderate-to-severe pemphigus vulgaris that hasn't responded to standard treatments. The therapy targets and depletes B cells, which are tho…

This study looks at whether taking coenzyme Q10 and vitamin C, alone or together, can improve healing and reduce dark gum color after surgical gum depigmentation. The trial involves 20 healthy adults with dark gums who undergo a simple scalpel procedure to remove pigmented tissue…

Researchers want to know whether some patients diagnosed with acquired aplastic anemia actually have an inherited bone marrow failure syndrome that was missed. The study enrolls children and adults with these conditions and collects clinical, laboratory, immune, and genetic data.…

This study examines how teledermoscopy, where skin lesion images are sent for remote review, affects referral patterns and skin cancer detection in clinical practice. It also tests whether artificial intelligence support tools improve diagnostic accuracy for doctors assessing the…

Researchers are testing whether a non-invasive eye scan can detect differences in the tiny blood vessels of the retina in people with psoriatic arthritis. The study compares three groups: people with psoriatic arthritis, people with psoriasis but no arthritis, and healthy volunte…

This pilot study is testing whether a rapid, point-of-care blood test can help identify early signs of infection and sepsis in preterm infants. Researchers will measure inflammatory markers like IL-6, PCT, CRP, and MxA in blood samples from about 40 to 80 premature babies, compar…

Researchers are testing whether two special light-based imaging methods show more detail in vitiligo spots than standard polarized dermoscopy. Adults with vitiligo have their spots photographed during a single visit using polarized dermoscopy, sub-ultraviolet reflectance imaging,…

This Canadian study tests whether adding two questions about morning stiffness and lower back pain to a standard screening tool (PEST) can help dermatologists identify psoriatic arthritis earlier in people with moderate-to-severe plaque psoriasis. About 502 adults who are candida…

This study is testing a software tool called Belle.ai that uses artificial intelligence to help doctors diagnose common skin diseases. About 400 patients at dermatology clinics will have three photos taken of their skin condition. The AI will analyze the photos and suggest possib…

This pilot study is testing a handheld imaging device called LC-OCT to see if it can clearly show the edges of basal cell skin cancers before Mohs surgery. Researchers will enroll 60 adults who are already scheduled for Mohs surgery. The goal is to find out if the images are good…

Proton therapy sends radiation into tumors, and researchers want to see exactly where that dose lands. This study tests radioacoustic imaging, which uses ultrasound sensors on the belly to pick up faint sound signals that proton radiation makes inside the body. The team will work…

Researchers at Johns Hopkins University are studying whether neuromuscular ultrasound and MRI can serve as reliable markers of swallowing muscle problems in people with inclusion body myositis (IBM). The study compares imaging and clinical findings in 30 participants, including p…

Researchers at Sohag University Hospital want to know how many women with acne also have polyendocrine metabolic ovarian syndrome, a hormonal and metabolic condition. The study enrolls 90 women aged 15 to 49 who have been diagnosed with acne. Doctors will check each participant f…

The ORACLE study watches people who have finished treatment for early-stage solid tumors, such as lung, breast, colon, and pancreatic cancers. Researchers want to see if a blood test called Guardant Reveal can find tiny traces of tumor DNA that might signal the cancer is coming b…

This Phase 3 trial tests whether a daily imiquimod cream applied to the face for 12 weeks can prevent new basal cell carcinomas (BCC) in 1,630 veterans at high risk. Participants apply either the active cream or a placebo and are followed for up to 3 years with skin exams. The go…

This study tests a decision support tool called CAPP-FIT to help prevent pressure injuries in people with spinal cord injury. About 808 veterans from 7 VA clinics will use a survey to identify risks, and providers get a report with recommended actions. The goal is to see if the t…

Researchers test whether heat education combined with physical changes to school buildings can lower indoor temperatures and reduce heat-related illnesses among primary school children in two climate-vulnerable districts of Bangladesh. The study compares solar reflective paint on…

Organ transplant recipients take drugs that suppress their immune system, which raises their risk of skin cancer. Researchers are testing whether nicotinamide, a form of vitamin B3, can prevent new skin cancers in kidney, liver, heart, and lung transplant patients who have alread…

Researchers are testing a disposable noninvasive skin closure device that sits on top of a surgical incision and reduces tension across the skin without piercing it. Adults aged 20 to 50 having plastic surgery on the cheek, neck, trunk, or limbs will wear the device on one half o…

People with head and neck cancer who have a tracheostomy and receive at least four weeks of radiation often develop severe skin reactions under the collar. This small study tests whether a silver-nylon dressing called Silverlon, already approved for radiation dermatitis, can prev…

This study tests whether leaving the white, creamy coating (vernix caseosa) on a newborn's skin for at least 24 hours after birth can prevent eczema (atopic dermatitis) during the first year of life. Over 1,300 mother-infant pairs in Chile will be randomly assigned to either keep…

Researchers at the University of Utah are testing a mobile health app designed to help young adults protect their skin from the sun. The study enrolls 20 people aged 18 and older who have had at least one sunburn in the past year or who rarely use sun protection. For four weeks, …

Researchers are testing whether sulforaphane, a substance found in broccoli and other cruciferous vegetables, can prevent melanoma in people who have multiple atypical moles and a prior history of melanoma. Participants take sulforaphane or a placebo by mouth. The trial measures …

This trial tests whether combining three light-based treatments can improve sun-damaged facial skin and possibly help prevent skin cancer. Researchers will treat one side of each participant's face with a thulium laser, an Er:Glass laser, and intense pulsed light, while the other…

This early-stage trial tests a cream made from inactivated Akkermansia muciniphila bacteria to prevent skin injury in 40 breast or head/neck cancer patients receiving radiation. The cream is applied three times daily to the radiation area. The main goal is to see if it is safe an…

This study tests whether the oral medication venlafaxine, typically used for depression, can prevent postherpetic neuralgia—a persistent nerve pain that often follows a shingles rash. Researchers will enroll 832 adults who have had a shingles rash for less than 30 days and are ex…

This trial tests whether clopidogrel, a common blood thinner, can prevent systemic sclerosis (scleroderma) in people who have Raynaud phenomenon and specific antibodies that put them at high risk. About 47% of such individuals develop full scleroderma within five years. Participa…

This study tests whether Acceptance and Commitment Therapy (ACT), delivered through a smartphone app, can help caregivers of children with RASopathies (like Neurofibromatosis type 1 and Noonan syndrome) cope with parenting stress. The trial is fully remote and involves 70 adult c…

Researchers are testing an experimental oral drug called soquelitinib in adults with moderate-to-severe hidradenitis suppurativa, a chronic skin condition that causes painful lumps and tunnels. The trial aims to see if the drug is safe and can reduce the number of inflammatory le…

This early-stage trial tests an experimental oral drug called TVB-3567 in 128 healthy adults, some with acne. The main goal is to check safety and how the body processes the drug, not yet whether it works. Results will help decide if larger studies are warranted.

This study tests an experimental daily tablet (PF-08049820) for adults with moderate to severe eczema (atopic dermatitis). About 165 participants will take either the study drug or a placebo for 12 weeks. Researchers will check skin improvement, itching, and safety through clinic…

Researchers are observing how skin surface appearance changes in adults with acne-prone skin during a course of PRX S, a topical cosmetic product applied in office. Thirty participants receive five sessions at two-week intervals plus a prescribed home care routine. The study uses…

Researchers are testing whether progressive muscle relaxation exercises can reduce fatigue and breathlessness and improve lung function in adults with systemic sclerosis, a condition also called scleroderma. The trial compares an exercise group that adds relaxation training to st…

This trial tests whether combining foam sclerotherapy with a transdermal laser clears spider and reticular leg veins more effectively than foam alone. Researchers will enroll 70 women with these veins on both legs, treating one leg with the combination and the other with foam onl…

This early-stage trial is testing a new injectable drug called ARQ-234 in healthy volunteers and people with moderate to severe eczema. The main goals are to check safety and how the body processes the drug, while also looking for early signs that it might improve eczema symptoms…

Researchers are testing an experimental cream called ENERGI-F703EB in adults with epidermolysis bullosa, a rare genetic condition that causes fragile skin and painful blisters. The trial enrolls about 24 people in Taiwan who have simplex, junctional, or dystrophic forms of EB. Ea…

This study tests whether Xdemvy eye drops can reduce eyelash mite irritation and improve comfort for people who wear special scleral lenses. Five adult lens users with moderate to severe Demodex blepharitis will use the drops and report changes in symptoms like dryness, itching, …

This study compares the standard dose of cetirizine (10 mg daily) to a higher dose (40 mg daily) for treating acute hives in adults. Researchers want to see if the higher dose relieves symptoms faster and reduces the need for steroid rescue medication. Participants take the assig…

This study compares giving the cancer drug nivolumab (Opdivo) as a shot at home versus in a clinic for people with various advanced cancers. The goal is to see if home treatment improves patients' overall care experience and quality of life. About 50 adults will receive the drug …

This study tests a new injectable filler made from hyaluronic acid and collagen to improve wrinkles, scars, and skin looseness on the face. Forty non-smoking adults aged 18-70 will receive one treatment and be followed for 16 weeks. Researchers will check for side effects and mea…

This study tests whether a high dose of gabapentin, a non-opioid pain medicine, can prevent the need for opioid painkillers in people with head and neck cancer who develop painful mouth sores from chemotherapy and radiation. About 228 participants will be randomly assigned to rec…

This trial tests whether a hybrid fractional laser can safely and effectively reduce acne scars in people with skin of color. About 50 adults with acne scarring will receive the laser treatment and be followed for nine months. Researchers will measure changes in scar severity, pa…

An episiotomy is a surgical cut made in the perineum during childbirth to help delivery. Many women experience pain, pelvic floor problems, and sexual difficulties afterward. This trial tests whether early individual physiotherapy, starting within three days of delivery and conti…

This study tests a cream containing FS2 (kynurenic acid) to see if it can reduce scarring in burn patients who need skin grafts. About 70 people aged 12 to 65 will apply the cream or a placebo to both the graft and donor sites for 90 days. The goal is to check safety and whether …

This study compares two preservative-free eye drops, Artelac Complete MDO and VISMED MULTI, for treating moderate to severe dry eye disease. About 160 adults who have used tear substitutes for at least a month will use one of the two drops for 90 days. Researchers will measure ch…

This study compares giving cancer treatment at home versus in a clinic for 27 adults with various cancers in the Florida Panhandle. The goal is to see if home treatment is preferred and improves satisfaction, while also checking safety. Participants will receive their usual cance…

This early-stage study tests a new drug called BBT001 in healthy volunteers and adults with moderate-to-severe atopic dermatitis (eczema). The main goal is to check safety and how the drug moves through the body. About 198 participants will receive either BBT001 or a placebo, wit…

This study tests whether a mobile app that provides psychological tools can improve quality of life for people with eczema, psoriasis, or chronic hives. Participants use the app over 32 weeks to learn coping strategies and wellness tips. The goal is to see if this digital approac…

This Phase 2 trial is testing an experimental drug called GHZ339 in 224 adults with moderate to severe atopic dermatitis (eczema). Participants will receive either the drug or a placebo, and researchers will measure changes in eczema severity using the EASI score at 16 weeks. The…

This study tests whether a new oral drug called ENV-294 can safely reduce eczema severity in adults with moderate-to-severe atopic dermatitis. Sixty participants will take either ENV-294 or a placebo pill daily for 12 weeks. Researchers will measure changes in skin symptoms and t…

Researchers are testing whether high-dose vitamin D helps heal bed sores in patients admitted to intensive care units. The trial enrolls 50 critically ill adults with low vitamin D levels and grade 1 or 2 pressure ulcers. Participants receive 50,000 IU of vitamin D3 in milk daily…

Researchers are testing whether adding cellular, acellular, or matrix-like wound products to standard care helps close pressure ulcers that have not healed. The trial enrolls about 500 adults with stage 3 or 4 pressure ulcers on the trunk that have lasted at least a month. Partic…

Researchers are testing whether adding cellular, acellular, or matrix-like wound products to standard care helps close nonhealing diabetic foot and venous leg ulcers better than standard care alone. The trial enrolls about 340 adults with type 1 or type 2 diabetes or venous leg u…

This study looks at whether a natural compound from licorice root, called glycyrrhetinic acid, can help calm irritated skin and repair the skin barrier. Researchers will apply a mild irritant to the skin of 30 healthy adults, then treat the area with a cream containing the compou…

This study tests a new medication called ARS-2 for people with chronic spontaneous urticaria (long-term hives). It aims to see if ARS-2 can quickly reduce itching and hives during flare-ups. The trial involves 42 adults who will receive either ARS-2 or a placebo during separate f…

This trial tests whether a depigmenting gel cream called Blancy Pro can reduce facial hyperpigmentation, including dark spots and melasma. Forty women aged 30 to 60 will apply the product daily for 90 days. Researchers will measure skin lightening using a colorimeter and clinical…

Researchers are testing a 1550nm non-ablative fractional laser on adults with skin concerns such as acne scars, wrinkles, and dark spots. The trial enrolls about 200 people aged 18 to 70. Participants receive laser treatment, then answer questionnaires about their experience. Der…

This study tests an experimental drug called ICP-332 for people with prurigo nodularis, a skin condition causing many intensely itchy bumps. About 135 adults will receive either the drug or a placebo to see if it reduces itching and clears the bumps over 16 weeks. The goal is to …

This study compares almond oil to hydroquinone cream for treating facial pigmentation in women with darker skin tones. Researchers will also check how each treatment affects the skin's microbiome. The goal is to see if almond oil is a safer, natural alternative to the standard tr…

This study tests whether diosmin, a citrus-based supplement, can safely heal open sores on the fingers of people with scleroderma. About 45 adults with at least one active digital ulcer will take either diosmin or a placebo for 8 weeks. Researchers will track ulcer healing, pain,…

This study is testing whether a special gel called StrataCTX can help people with skin reactions from cutaneous T-cell lymphoma (CTCL) or cancer treatments use less steroid cream. Steroid creams can have side effects when used a lot, so finding an alternative is important. The st…

This pilot study tests whether quercetin, a natural antioxidant found in many plants, is safe for people with Dyskeratosis congenita or telomere biology disorders. Twelve participants will take quercetin for 24 weeks while researchers monitor side effects and how well people stic…

This study looks at whether lowering salt in your diet can make eczema less severe. Forty adults with eczema will eat a low-salt diet for 24 weeks. For 5 weeks they'll take salt pills, and for another 5 weeks they'll take placebo pills, to see the real effect of sodium. Researche…

This study compares a new emollient balm made from seawater (Relipid+) to a leading balm (Lipikar) for mild to moderate eczema in people aged 6 months to 70 years. The goal is to see if the new balm works just as well at reducing symptoms and improving skin health. Researchers wi…

This study looks at how well the drug nemolizumab works for adults with moderate-to-severe prurigo nodularis, a skin condition that causes intense itching and bumps. Researchers will track 600 participants over 6 months in real-world clinics, measuring itch severity and skin lesi…

This early-stage trial tested an experimental oral drug called BGB-16673 in 34 adults with chronic spontaneous urticaria (CSU), a condition causing persistent hives and itching. The study was double-blind and placebo-controlled, meaning neither patients nor doctors knew who got t…

This trial tests whether two simple distractions — watching a betta fish or playing with a hand puppet — can lower pain, fear, and anxiety in children aged 5 to 7 during a blood draw. One group will use the fish, another the puppet, and a third will receive standard care. Researc…

Researchers are testing an experimental ointment called IN-115314 in adults with mild to moderate atopic dermatitis, a common form of eczema. The trial compares two strengths of the ointment, 1% and 3%, against a placebo ointment. Participants apply the treatment twice daily for …

This study tests whether Radiesse (calcium hydroxylapatite) injections can restore facial volume and improve skin quality in people who lose facial fullness from GLP-1 weight loss drugs like semaglutide. 48 adults starting GLP-1 therapy will be randomly assigned to receive either…

Researchers are testing whether adding tranexamic acid to standard numbing injections reduces bleeding, swelling, and bruising during and after nasal reconstruction surgery for skin cancer. The trial enrolls about 100 adults who are having a local flap repair of a nasal defect af…

This early-stage study tests a single dose of an experimental drug called GTX-B001 in healthy people and those with chronic inducible urticaria—a condition where cold or scratching causes painful hives. The main goal is to check safety and how the body handles the drug. About 72 …

This trial tests whether regular use of a digital mindfulness meditation app can help adolescents aged 12-17 with moderate to severe atopic dermatitis (eczema) improve disease control and quality of life. Participants will use the app for 10-15 minutes, 3-4 times a week, while a …

This study tests whether a special dermocosmetic cream can reduce facial redness and visible blood vessels in people with a common type of rosacea. Fifty adults will apply the cream to one side of their face and a placebo to the other, twice daily for two months, then continue wh…

This Phase 2 study tests an experimental ointment called GX-03 in adults with moderate-to-severe eczema. About 110 to 200 participants will apply either the active ointment or a placebo for 8 weeks. Researchers will measure improvements in skin rash, itch, and patient-reported sy…

This trial tests whether zinc oxide ointment improves scar healing compared with plain petrolatum after skin surgery. Adults with a surgical cut at least 4.5 cm long on non-scalp skin will apply each ointment to half of the scar daily for a month. Researchers will compare scar ap…

This study tests whether two types of facial sunscreen (untinted and tinted) can improve dark spots caused by melasma, sun spots, or post-inflammatory hyperpigmentation. Adult participants with mild to moderate dark spots apply the sunscreen at least twice daily for 56 days. Rese…

This early-phase trial is testing whether injecting the seasonal flu vaccine directly into skin cancer tumors can boost the immune system's attack on the cancer. About 25 people with cutaneous squamous cell carcinoma will receive one injection into their tumor before standard sur…

This study aims to uncover the genetic causes of hereditary leiomyomatosis renal cell cancer (HLRCC), a condition that can lead to painful skin bumps, uterine fibroids, and kidney tumors. Researchers will study people with known or suspected HLRCC and their family members to iden…

This study tests a non-invasive imaging technique called LC-OCT for diagnosing basal cell carcinoma, the most common skin cancer. Researchers will review medical records of about 300 patients to see if LC-OCT can accurately detect cancer and guide treatment without needing a biop…

This study investigates whether certain environmental exposures—like infections, stress, or sun exposure—are more common in people with anti-synthetase syndrome, a rare autoimmune condition that causes muscle weakness and lung disease. Researchers will compare 580 participants, i…

This study collects blood, urine, bone marrow, and tumor samples from people with hairy cell leukemia and other blood cancers, as well as from healthy volunteers. Researchers will use these samples to study the diseases and develop new treatments called immunotoxins, which use an…

This study aims to understand why some people are more prone to fungal infections, especially from Candida yeast. Researchers will collect blood, saliva, urine, and tissue samples from people with immune disorders, their family members, and healthy volunteers. No treatment is giv…

This study is looking for 500 people with certain cancers (like eye or skin melanoma, kidney cancer, or mesothelioma) and their family members to understand how common BAP1 gene mutations are. Researchers will collect medical history and questionnaires to learn about cancer risks…

Researchers are studying how remibrutinib, an experimental drug that blocks an immune enzyme called Bruton's tyrosine kinase, affects skin tissue in adults with moderate to severe hidradenitis suppurativa. About 30 participants will receive either remibrutinib or a placebo for a …

This natural history study follows up to 4,000 people with inherited bone marrow failure syndromes (IBMFS) and their families to learn why they are prone to certain cancers. Researchers will track health over time, collect genetic samples, and look for clues that separate those w…

This study looks at how leishmaniasis infections progress and respond to treatment. It involves up to 289 people aged 3 to 100 with known or suspected leishmaniasis. Researchers will collect blood and tissue samples to learn more about the disease and test different treatments. T…

This study follows 950 people with idiopathic CD4+ lymphocytopenia (ICL), a rare condition where low CD4+ white blood cells raise infection risk. Researchers will track participants for up to 10 years, collecting medical history, blood samples, and infection data. The goal is to …

Researchers compare body composition in women with lipedema and women with obesity who have similar age and body mass index. They use bioelectrical impedance analysis to measure fat and muscle in the legs, arms, and trunk. The study tests whether women with lipedema have a higher…

This study aims to collect blood, nasal fluid, skin cells, urine, and medical data from 10,000 people aged 3 to 100 with allergies, asthma, eczema, or sinus issues. Participants will have up to 3 years of follow-up visits and questionnaires. The goal is to create a large reposito…

Radiation therapy for head and neck or pelvic cancers often irritates the skin, a condition called radiation-induced dermatitis. Researchers will follow 80 adults receiving radiation or combined chemotherapy and radiation, checking their skin weekly for five to seven weeks. The s…

This study is a long-term registry that collects health information from people with Fabry disease, a rare genetic disorder. It does not test any new treatments; instead, it follows up to 9,000 patients worldwide to better understand how the disease progresses and how current tre…

This study checks how well pulse oximeters measure blood oxygen during mild to severe low oxygen levels in 10,000 healthy adults aged 18-50. Researchers compare the device's reading to a precise blood test, and also look at how skin pigmentation affects accuracy. The goal is to m…

This study looks at the causes and effects of food allergies and related conditions like eczema and eosinophilic esophagitis. Researchers will collect blood, skin, and genetic samples from up to 1,800 people over many years. The goal is to find biomarkers and pathways that explai…

This study is testing whether artificial intelligence can accurately classify skin pigment, sun sensitivity (phototype), and sun damage from standard photos of the arm. Researchers will enroll 1,500 adults from diverse backgrounds, combining objective color measurements, expert a…

This study aims to learn more about Hermansky-Pudlak Syndrome (HPS), a rare inherited disease that causes light skin/eye color, bleeding problems, and often deadly lung scarring. Researchers will follow 600 people with HPS and their family members to track how the disease progres…

This study is testing a new imaging tool called OCT Vibrography that measures how stiff or flexible tissues like the cornea, skin, and gums are. About 90 healthy volunteers will have the device used on them to see if it works safely. No treatment or medication is involved—just ob…

This study looks at the tiny organisms living on our skin—like bacteria and fungi—and how they might differ in people with eczema (atopic dermatitis). Researchers will collect skin samples from healthy volunteers and patients aged 2 to 40 with moderate to severe eczema, as well a…

This observational study looks at whether time spent driving is linked to differences in skin hydration between the left and right cheeks in female drivers in Florida. In left-hand-drive cars, the left cheek gets more sun exposure through the side window. Researchers will measure…

This study aims to learn more about insulin resistance and diabetes by collecting blood and skin samples from up to 1,200 participants, including patients with severe insulin resistance and their family members. Researchers will study genetics and how insulin works in the body to…

This study aims to find how common the KIT D816V mutation is in people with suspected clonal mast cell disease. Researchers will collect blood samples from 450 participants and test them using two sensitive methods. The results may improve understanding and diagnosis of these rar…

This study is testing a new predictive model that analyzes tumor samples to forecast whether a patient with melanoma or other skin cancers will respond to immunotherapy. Researchers will compare the model's predictions with actual patient outcomes over six months. The goal is to …

This study looks at how families feel about antibiotic use and whether a Garmin smartwatch can track symptoms in children aged 4-17 with common infections like UTIs, tonsillitis, or skin infections. About 300 children from the Royal Children's Hospital Emergency Department will w…

This study is a global registry that will follow about 150 people with acute hepatic porphyria (AHP) over time. Researchers will collect information on how the disease progresses, how it is managed in real-world settings, and the safety and effectiveness of approved treatments li…

This study will measure how much of the drug TREMFYA (guselkumab) passes into breast milk of 10 nursing women who are already taking it for conditions like psoriasis, psoriatic arthritis, ulcerative colitis, or Crohn's disease. Researchers will collect milk samples to estimate th…

This study is a registry that gathers medical information from up to 100 people who have either large dark skin patches present at birth or a rare brain condition called neurocutaneous melanocytosis. The goal is to collect data on how these conditions are treated and how they pro…

This study aims to learn more about RASopathies, a group of genetic conditions that can cause developmental issues, birth defects, and increased cancer risk. Researchers will follow up to 500 people of any age who have or may have a RASopathy, along with their family members, for…

This study aims to understand how genetics and environmental factors contribute to melanoma, a serious skin cancer. Researchers will enroll up to 3,000 people with a personal or family history of melanoma or related conditions. Participants will fill out questionnaires, provide b…

Researchers are following pregnant women with psoriasis who took deucravacitinib, an oral drug for the skin condition, to see whether it affects pregnancy or infant health. The study enrolls about 900 women through a North American pregnancy registry and compares them with women …

This study aims to find the genetic causes of Ollier disease and Maffucci syndrome, rare disorders that cause cartilage tumors and increase cancer risk. Researchers will study 100 people aged 2 and older using blood tests, scans, and genetic sequencing. Participants will stay at …

This study looks at how the body processes venetoclax when the tablet is crushed and mixed into a liquid. It includes 30 children and young adults with blood cancers who already take venetoclax this way. The goal is to measure drug levels in the blood and spinal fluid to ensure t…

Researchers in Nice are studying how glucose metabolism affects dendritic cells, immune cells that help drive psoriasis. They will take skin biopsies and blood samples from people with moderate to severe psoriasis, some with type 2 diabetes and some without, and compare them with…

Researchers at Can Tho University of Medicine and Pharmacy are studying how the bacteria on the face change in people with moderate-to-severe acne while they take oral isotretinoin, a standard acne medicine. About 90 participants aged 12 to 35 will give facial skin swabs before t…

This study is a registry that will follow 1,000 adults and teens with atopic dermatitis (eczema) who are starting or switching systemic treatments. Researchers will track which treatments people use, how long they take them, and why they change or stop. The goal is to better unde…

This study follows 580 people with dystrophic or junctional epidermolysis bullosa (EB) for up to 5 years. Researchers want to see if using Filsuvez, a birch bark extract gel that helps heal blisters, changes the risk of developing skin cancer. Participants receive standard care, …

This study observes how people with psoriasis receive care in different countries. Researchers will collect data from routine doctor visits to understand treatment patterns, disease severity, and quality of life. The goal is to identify gaps in healthcare delivery and improve out…

Researchers are studying whether blood levels of a molecule called Substance P are linked to pain, itching, and quality of life in adults with chronic plaque psoriasis. The study compares three groups: people taking IL-17 inhibitor biologics, people taking older systemic drugs li…

This international study observes how people with hidradenitis suppurativa (a chronic skin condition) access healthcare, what treatments they receive, and how the disease affects their quality of life. Researchers collect data from routine medical records across multiple countrie…

This study examines how common eczema treatments, including antibiotics and bleach baths, change the types and amounts of bacteria on the skin. Researchers will compare people with eczema to healthy volunteers. The goal is to understand the skin microbiome better, not to test a n…

This study looks at how hormones and metabolism are involved in pulmonary arterial hypertension (PAH), a serious lung condition. Researchers will measure sex hormone levels, insulin resistance, and test two potential treatments—metformin and ACE-2—in small groups. The goal is to …

This study follows 5,000 people with common inflammatory skin conditions—like eczema, psoriasis, and hidradenitis suppurativa—over up to 17 years to see how their disease severity changes. Researchers will collect medical history, treatments, and symptom scores to identify factor…

This study looks at whether pulse oximeters—the clips placed on fingers to measure oxygen levels—work equally well for children with different skin tones who have congenital heart disease. Researchers will enroll 92 children under 18 undergoing heart surgery and compare the oxime…

This study aims to create a large collection of blood samples from 2,500 people with or at high risk for cancer. Researchers will use these samples to study liquid biopsies, which are blood tests that may help detect cancer, track treatment response, and spot recurrence. Particip…

This study aims to learn more about myositis, a group of diseases that cause muscle inflammation and damage. Researchers will observe up to 1,200 children and adults with myositis, along with healthy volunteers, to track changes in the immune system and other health problems over…

This study aims to collect medical information and tissue samples from 500 people with suspected or confirmed inflammatory muscle diseases, as well as healthy volunteers. Researchers will use blood, muscle, and skin samples to study what causes these diseases and how they progres…

This study tests an educational website designed to help people detect skin cancer early. About 280 participants in Singapore will use either a gain-framed or loss-framed version of the program, or no program at all. Researchers will measure how well participants can tell benign …

This study looks at whether older adults (75+) with early-stage melanoma can safely skip an extra lymph node biopsy after their main surgery. The goal is to see if the simpler surgery alone works just as well and improves overall well-being. About 428 participants will be followe…

This study follows 819 children under 2 years old who have medium to giant congenital nevi (pigmented birthmarks). Researchers will track neurological development, melanoma risk, and quality of life over time. The goal is to create better monitoring and treatment guidelines for t…

This study looks at whether using genetic markers from a child's skin tumor can help doctors decide how much surgery is needed. About 51 children and young adults up to age 25 with localized melanoma or similar growths will have their tumor tissue reviewed centrally. Based on ris…

Researchers are collecting information on pregnant women who took the antifungal medicine ibrexafungerp, which treats vaginal yeast infections. The study follows their babies from birth through the first year of life, looking for birth defects, growth problems, and developmental …

Systemic sclerosis is a rare autoimmune disease that causes thickening and scarring of the skin and internal organs. Researchers at Peking University Third Hospital are building a cohort of 150 patients in China to follow how the disease changes over time. The study measures skin…

This study aims to understand how the immune system and skin healing are connected in people with primary immunodeficiency, psoriasis, or eczema, as well as in healthy volunteers. Researchers will collect skin biopsies, blood samples, and optional skin swabs to analyze microbes a…

Researchers want to know whether a liver protein called TMPRSS6 relates to blood sugar control, lipid levels, body fat, and liver health in people with leptin receptor deficiency or genetic lipodystrophy. These rare conditions cause severe obesity, extreme hunger, or loss of body…

This study collects biological samples—like blood, skin biopsies, and swabs—from people with or at risk for skin diseases, as well as healthy volunteers. Researchers will use these samples to study the causes of skin conditions and explore potential treatments. Up to 700 particip…

Some people with severe chronic hives keep getting welts and itching even after high-dose omalizumab, a biologic shot. Researchers in France are reviewing the medical records of about 73 adults whose hives did not respond to that optimized treatment. The goal is to describe their…

This study investigates how inflammatory genes are regulated in people with hidradenitis suppurativa (HS), a chronic skin condition causing painful lumps. Researchers will compare inflammatory markers in HS patients versus healthy controls. An optional sub-study explores whether …

This study looks at how much of the drug bimekizumab passes into breast milk. Researchers will collect milk samples from 20 breastfeeding mothers with conditions like psoriasis or arthritis over several weeks. The goal is to understand potential exposure for nursing infants, not …

This study collects moles and blood samples from 50 adults to analyze the genetic mutations that cause moles to form. Researchers will compare DNA from mole tissue with normal DNA from blood to find specific changes. No treatments or interventions are given—the goal is purely to …

This study will test a new device that uses a camera and machine learning to measure foot pressure and foot area. Researchers will compare it to the current standard pressure mat in 150 healthy adults. The goal is to see if the new tool is accurate and reliable enough for future …

This study looks back at the medical records of about 140 people with a rare blood cancer called blastic plasmacytoid dendritic cell neoplasm (BPDCN) who received chemotherapy as their first treatment. The goal is to see how effective and safe different chemotherapy regimens are …

This study is testing a handheld device called Nevisense Go to see if it can predict eczema (atopic dermatitis) flares before they become visible or cause symptoms. About 450 people aged 12 to 89 with a history of eczema flares will use the device at home for 90 days. The goal is…

Researchers at Biruni University are studying whether baseline blood levels of three hormones (DHEAS, FSH, and LH) are linked to how well adult women with moderate to severe acne respond to the drug isotretinoin. The trial enrolls 64 women aged 18 and older who are starting syste…

Researchers are investigating whether wound dressings coated with dialkylcarbamoyl chloride (DACC) can bind bacteria and fungi from hard-to-heal wounds. The study enrolls 30 adults with wounds such as diabetic foot ulcers, venous leg ulcers, pressure ulcers, or arterial leg ulcer…

This study tracks 100 adults with mycosis fungoides or Sézary syndrome who are starting mogamulizumab, a standard treatment. The drug often causes a rash that can look like the cancer itself. Researchers want to help doctors tell the difference so they don't stop a working drug t…

This study follows 80 adults in Canada with moderate-to-severe psoriasis who are starting the drug tildrakizumab. Researchers want to see how the treatment affects quality of life and skin clearing over one year, especially in people with darker skin tones (Fitzpatrick type III a…

This study compares two types of visual cues during treadmill walking in 36 athletes who had ACL reconstruction. One cue is a steady beat (isochronous), the other has natural fluctuations (fractal). The goal is to see which better restores natural walking patterns and brain activ…

Acute intermittent porphyria (AIP) is an inherited disorder that can cause sudden, severe attacks, but not everyone who carries the gene gets sick. Researchers at Mount Sinai are collecting blood, saliva, and urine samples from about 150 people in AIP families, including affected…

This study is creating a registry of up to 1,000 people with rare lymphatic system disorders. Researchers will collect information from medical records and yearly surveys to understand how these diseases progress, what treatments are used, and how they affect quality of life. The…

This study looks at whether changing how much salt you eat can affect skin sodium levels and the severity of eczema or psoriasis. Fifty adults will follow a low-salt diet and take either sodium tablets or a placebo for several weeks. The goal is to see if this approach is practic…

Researchers are tracking how lebrikizumab, a treatment for atopic dermatitis, changes the community of fungi, bacteria, and Staphylococcus on the skin. The study enrolls 60 adults with eczema who are starting lebrikizumab. Skin swabs taken before treatment and at weeks 4 and 16 w…

This study tests three non-invasive imaging devices on adults with basal cell carcinoma, the most common skin cancer. Researchers measure how long each scan takes, how comfortable it feels, and how well the tools work on different body areas. Participants attend one 40-minute vis…

This study looks at 40 adults with psoriasis—some with joint pain (psoriatic arthritis) and some without—to compare immune signals in their blood and skin. Researchers want to understand why some people develop joint problems. Participants give blood and skin samples for lab anal…

This study is creating a registry for children with PTEN Hamartoma Tumor Syndrome (PHTS), a rare genetic condition that increases cancer risk. Researchers will follow 100 participants for 3 years to link genetic changes with health outcomes. The goal is to develop better monitori…

This study looks at blood and skin samples from people with mycosis fungoides and Sézary syndrome, rare types of lymphoma that affect the skin. Researchers want to find biological markers that can predict how the disease will progress and how well a patient might respond to treat…

This study aims to create a network of biobanks across Italy that collect and store biological samples and health data from people with rare diseases and their families. The goal is to standardize how samples are collected and shared, so researchers can access high-quality materi…

This study investigates whether six specific Leishmania antigens can activate T-cells in blood and tissue samples from patients with visceral and cutaneous leishmaniasis. Researchers will compare responses before and after treatment, and against healthy volunteers, to see if thes…

This study investigates whether systemic sclerosis, a rare autoimmune disease, changes the community of bacteria living in the mouth. Researchers will collect dental plaque samples from 30 participants—some with scleroderma and some without—to compare the types and functions of o…

This study aims to understand the cellular and molecular mechanisms behind systemic sclerosis (SSc), a rare autoimmune disease that causes skin and organ fibrosis. Researchers will collect skin punch biopsies and blood samples from 500 participants, including those with SSc and h…

This study follows people with SPLIS, a rare inherited metabolic condition, to map its natural history—how the disease unfolds over time. Researchers will track growth, organ function, quality of life, and survival in about 28 participants. The goal is to understand the full rang…

This study compares oxygen readings taken from the finger and the earlobe during a six-minute walk test in people with interstitial lung disease. The goal is to see if one location gives more accurate measurements of oxygen levels during exercise. The results could help doctors d…

Lichen sclerosus is a chronic skin condition that causes itching, pain, and scarring, often in the genital area, and raises the risk of skin cancer. This study aims to identify genetic variants linked to the disease by analyzing DNA from families that have multiple members with l…

This observational study investigates factors linked to sodium stored in the skin of healthy adults and people with atopic dermatitis (eczema) aged 50 and older. Researchers aim to see if diet and skin barrier function affect skin sodium levels, and whether those levels are tied …

This study looks at keloid scars—raised, overgrown scars that can be itchy or painful—to understand why they form. Researchers will compare keloid tissue with normal skin from the same person, using lab tests to spot key molecules that drive scar growth. The goal is to uncover ne…

This study observes patients with high-risk stage II melanoma to see if starting anti-PD-1 immunotherapy before surgery leads to better outcomes compared to the usual timing after surgery. Researchers will track when patients begin systemic therapy and compare results between the…

This study investigates how changes in kidney cell metabolism relate to the rate of kidney function decline in people with ANCA vasculitis and other kidney diseases. Researchers will analyze kidney biopsy samples and blood/urine tests from 146 participants over one year. The goal…

This study tests whether an artificial intelligence (AI) model can accurately classify basal cell carcinoma (a common skin cancer) as low-risk or high-risk using dermoscopic images. Researchers will also see if the AI can predict specific subtypes of the cancer. The model's perfo…

This study investigates clonal hematopoiesis (CH) — small mutations in blood cells that can arise naturally or after cancer treatment — in adults receiving chemotherapy or radiation for solid tumors like breast, lung, or colorectal cancer. Researchers will collect blood, saliva, …

This study looks at skin problems that appear during a COVID-19 infection, with a special focus on chilblains (painful red or purple bumps on fingers or toes). Researchers want to understand why these skin changes happen—whether from the virus itself, tiny blood clots, or inflamm…

This international study observes how people with atopic dermatitis (eczema) access healthcare, what treatments they receive, and how the disease affects their daily lives. Researchers will collect data from routine medical records of about 9,600 participants across multiple coun…