New drug trial hopes to thicken skin Disease's fate

NCT ID NCT07287670

Recruiting now Disease control Sponsor: Mediar Therapeutics Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 06, 2026 · Updated 2 times

Summary

This study tests an experimental drug called MTX-474 in 85 people with diffuse cutaneous systemic sclerosis, a condition that causes skin thickening and organ damage. Participants will receive either MTX-474 or a placebo for 24 weeks to see if the drug safely reduces skin thickness and improves disease-related gene activity. The goal is to control the disease, not cure it.

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Conditions

The condition(s) this trial relates to.

diffuse cutaneous systemic sclerosis diffuse scleroderma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIFFUSE CUTANEOUS SYSTEMIC SCLEROSIS

Contacts and locations

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Locations

Aotearoa Clinical Trials
RECRUITING

Auckland, 2025, New Zealand
Austin Health
RECRUITING

Heidelberg, Victoria, 3084, Australia
Baylor Scott & White Research Institute
RECRUITING

Dallas, Texas, 75246, United States
Boston Medical Center
RECRUITING

Boston, Massachusetts, 02118, United States
Brigham and Women's Hospital
RECRUITING

Boston, Massachusetts, 02115, United States
Clinical Research of West Florida
RECRUITING

Clearwater, Florida, 33765, United States
Clinical Research of West Florida
RECRUITING

Tampa, Florida, 33606, United States
EncompaSSc site in Ancona, Italy
NOT_YET_RECRUITING

Ancona, 60126, Italy
EncompaSSc site in Barcelona, Spain
NOT_YET_RECRUITING

Barcelona, 08003, Spain
EncompaSSc site in Barcelona, Spain
NOT_YET_RECRUITING

Barcelona, 08025, Spain
EncompaSSc site in Brasov, Romania
NOT_YET_RECRUITING

Brasov, 500283, Romania
EncompaSSc site in Brooklyn, NY
NOT_YET_RECRUITING

Brooklyn, New York, 11201, United States
EncompaSSc site in Bucharest, Romania
NOT_YET_RECRUITING

Bucharest, 030463, Romania
EncompaSSc site in Bucharest, Romania
NOT_YET_RECRUITING

Bucharest, 041303, Romania
EncompaSSc site in Bydgoszcz, Poland
NOT_YET_RECRUITING

Bydgoszcz, 85-168, Poland
EncompaSSc site in Catania, Italy
NOT_YET_RECRUITING

Catania, 95123, Italy
EncompaSSc site in Cleveland, OH
NOT_YET_RECRUITING

Cleveland, Ohio, 44195, United States
EncompaSSc site in Córdoba, Spain
NOT_YET_RECRUITING

Córdoba, 14004, Spain
EncompaSSc site in Genoa, Italy
NOT_YET_RECRUITING

Genoa, 16132, Italy
EncompaSSc site in Groningen, Netherlands
NOT_YET_RECRUITING

Groningen, 9713 GZ, Netherlands
EncompaSSc site in Hamilton, NZ
NOT_YET_RECRUITING

Hamilton, 3204, New Zealand
EncompaSSc site in Houston, TX
NOT_YET_RECRUITING

Houston, Texas, 77030, United States
EncompaSSc site in Kansas City, KS
NOT_YET_RECRUITING

Kansas City, Kansas, 66103, United States
EncompaSSc site in La Jolla, CA
NOT_YET_RECRUITING

La Jolla, California, 92037, United States
EncompaSSc site in La Tronche, France
NOT_YET_RECRUITING

La Tronche, 38700, France
EncompaSSc site in Liverpool, UK
NOT_YET_RECRUITING

Liverpool, L7 8XP, United Kingdom
EncompaSSc site in Loma Linda, CA
NOT_YET_RECRUITING

Loma Linda, California, 92350, United States
EncompaSSc site in London, UK
NOT_YET_RECRUITING

London, SW8 3RN, United Kingdom
EncompaSSc site in Malaga, Spain
NOT_YET_RECRUITING

Málaga, 29004, Spain
EncompaSSc site in Milan, Italy
NOT_YET_RECRUITING

Milan, 20122, Italy
EncompaSSc site in Minneapolis, MN
NOT_YET_RECRUITING

Minneapolis, Minnesota, 55455, United States
EncompaSSc site in Modena, Italy
NOT_YET_RECRUITING

Modena, 41124, Italy
EncompaSSc site in Montpellier, France
NOT_YET_RECRUITING

Montpellier, 34090, France
EncompaSSc site in Nowa Sól, Poland
NOT_YET_RECRUITING

Nowa Sól, 67-100, Poland
EncompaSSc site in Oklahoma City, OK
NOT_YET_RECRUITING

Oklahoma City, Oklahoma, 73104, United States
EncompaSSc site in Palo Alto, CA
NOT_YET_RECRUITING

Palo Alto, California, 94304, United States
EncompaSSc site in Paris, France
NOT_YET_RECRUITING

Paris, 75014, France
EncompaSSc site in Philadelphia, PA
NOT_YET_RECRUITING

Philadelphia, Pennsylvania, 19107, United States
EncompaSSc site in Phoenix, AZ
NOT_YET_RECRUITING

Phoenix, Arizona, 85054, United States
EncompaSSc site in Pittsburgh, PA
NOT_YET_RECRUITING

Pittsburgh, Pennsylvania, 15219, United States
EncompaSSc site in Roma, Italy
NOT_YET_RECRUITING

Roma, 00128, Italy
EncompaSSc site in Sarasota, FL
NOT_YET_RECRUITING

Sarasota, Florida, 34239, United States
EncompaSSc site in Southport, Australia
NOT_YET_RECRUITING

Southport, Queensland, 4222, Australia
EncompaSSc site in Strasbourg, France
NOT_YET_RECRUITING

Strasbourg, 67000, France
EncompaSSc site in Timişoara, Romania
NOT_YET_RECRUITING

Timișoara, 300133, Romania
EncompaSSc site in Toulouse, France
NOT_YET_RECRUITING

Toulouse, 31059, France
EncompaSSc site in Valencia, Spain
NOT_YET_RECRUITING

Valencia, 46026, Spain
EncompaSSc site in Vandœuvre-lès-Nancy, France
NOT_YET_RECRUITING

Vandœuvre-lès-Nancy, 54500, France
EncompaSSc site in Walsgrave Coventry, UK
NOT_YET_RECRUITING

Coventry, CV2 2DX, United Kingdom
EncompaSSc site in Warszawa, Poland
NOT_YET_RECRUITING

Warsaw, 00-874, Poland
EncompaSSc site in Warszawa, Poland
NOT_YET_RECRUITING

Warsaw, 02-507, Poland
EncompaSSc site in Westcliff-on-Sea, UK
NOT_YET_RECRUITING

Westcliff-on-Sea, SS0 0RY, United Kingdom
EncompaSSc site in Woolloongabba, Australia
NOT_YET_RECRUITING

Woolloongabba, Queensland, 4102, Australia
Johns Hopkins University
RECRUITING

Baltimore, Maryland, 21205, United States
NewportNativeMD, Inc.
RECRUITING

Newport Beach, California, 92663, United States
Stryde Research - DFW
RECRUITING

Allen, Texas, 75013, United States

Contact Email: •••••@•••••
University of California Los Angeles Scleroderma Center
RECRUITING

Los Angeles, California, 90095, United States
University of Colorado Center for Lungs/Breathing/Scleroderma Clinic
RECRUITING

Aurora, Colorado, 80045, United States

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