Simple gel may prevent painful side effect of liver cancer drug

This study tests if applying a topical gel (indomethacin) to the hands before starting sorafenib can prevent or reduce hand-foot skin reactions, a common and painful side effect. About 39 adults with advanced liver cancer will use the gel twice daily for up to 12 weeks. The goal is to see if this simple approach helps patients stay on their cancer treatment with less discomfort.