Could a common anesthetic help prevent liver cancer from coming back?
NCT ID NCT07657897
First seen Jun 27, 2026 · Last updated Jul 22, 2026 · Updated 2 times
Summary
This study looks at whether adding lidocaine to standard sedation during radiofrequency ablation for liver cancer can reduce inflammation and lower the chance of the cancer returning. The researchers focus on a process called NETosis, which is linked to tumor growth and spread. One hundred people with small liver tumors (up to 3 cm) will be randomly assigned to receive either standard sedation or sedation plus lidocaine, and their outcomes will be tracked for one year.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- lidocaine
- What this could lead to
- If lidocaine reduces NETosis and recurrence, it could offer a simple, low-cost way to improve outcomes after liver cancer ablation.
- What could go wrong
- This is a small, early-stage study (100 participants) testing a biomarker-driven idea; results may not confirm benefit, and lidocaine's effect on recurrence is unproven.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
"Prof. Dr. Octavian Fodor" Regional Institute of Gastroenterology and Hepatology, Cluj-Napoca, Romania
RECRUITINGCluj-Napoca, Cluj, 400394, Romania
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