SEDATION AND ANALGESIA

This study looks at whether adding lidocaine to standard sedation during radiofrequency ablation for liver cancer can reduce inflammation and lower the chance of the cancer returning. The researchers focus on a process called NETosis, which is linked to tumor growth and spread. O…

This study looks at two ways to manage sedation in COPD patients who need a breathing machine (ventilator). One group gets no sedation at all, while the other has their sedation paused every day. The goal is to see which approach helps patients spend more days off the ventilator …

This study compares two drug combinations (ketamine with propofol vs. dexmedetomidine with propofol) for sedating children aged 2-12 during a heart catheterization to close simple heart defects. The goal is to see which approach causes fewer breathing problems and provides smooth…

This study compares two sedatives—remimazolam and midazolam—in 440 critically ill patients on breathing machines. The goal is to see if remimazolam helps patients come off the ventilator faster. Participants are randomly assigned to one drug, and researchers track how long they n…

This study tests whether interventional radiologists can safely give deep sedation using ketamine, fentanyl, and midazolam for procedures that normally require general anesthesia. Up to 40 adults will participate. The main goal is to see if the procedure can be completed without …

This study tests whether giving acetaminophen (Tylenol) and ketorolac (Toradol) to children on ventilators can better control pain and reduce the need for strong opioids. About 644 children aged 2 months to 17 years with acute respiratory failure will be randomly assigned to rece…

This study looks at how painkillers and sedatives are given to patients on ECMO, a life-support machine for severe heart or lung failure. Researchers will first review current sedation practices in UK hospitals, then work with patients, families, and staff to design a safer sedat…

This study looks at how two common anesthesia drugs, propofol and alfentanil, change brain activity during a procedure called ERCP (a scope exam of the bile ducts). Researchers will monitor 20 patients' brain waves and pain signals to better understand how these drugs work togeth…

This study compares cannabis users and non-users during wisdom tooth removal under IV sedation. Researchers will measure how much sedative medication is needed and track vital signs like heart rate and blood pressure. The goal is to understand if cannabis use changes how people r…

This study looks at how often pain occurs in intensive care unit (ICU) patients who are on mechanical ventilators (breathing machines). Researchers will observe 370 adults, using special pain scales to measure pain on the second day of ventilation and when they first wake up. The…