SEDATION AND ANALGESIA

This study looks at two ways to manage sedation in COPD patients who need a breathing machine. One group gets no sedation, while the other has their sedation paused each day. The goal is to see which approach helps patients spend more days breathing without the machine. The study…

This study compares two sedative drugs, remimazolam and midazolam, in critically ill patients who need a breathing machine (ventilator). The goal is to see if remimazolam helps patients come off the ventilator sooner. About 440 adults in intensive care will take part, and they wi…

This study compares two standard pain medicines, fentanyl and hydromorphone, in 300 ICU patients who need a breathing machine. The goal is to see if one leads to better outcomes, such as using less opioid medicine overall and improving recovery. Participants will receive one of t…

This study tests whether adding non-opioid pain medicines (acetaminophen/Tylenol and ketorolac/Toradol) can improve pain control and reduce the need for strong opioids in children on breathing machines. About 644 children aged 2 months to 17 years with acute respiratory failure w…

This study tests whether interventional radiologists can safely give deep sedation (using ketamine) for procedures that normally require general anesthesia. The goal is to see if this approach works well and is safe, with anesthesiologists on standby if needed. About 40 adults wi…

This study looks at people having their wisdom teeth removed under deep sedation. Researchers will compare cannabis users and non-users to see if they need different amounts of sedative drugs or have different vital signs during the procedure. The goal is to understand how cannab…

This study looks at how common pain is in intensive care unit (ICU) patients who are on breathing machines (mechanical ventilators). Researchers will use special pain scales to check pain levels and see if pain is linked to problems like breathing trouble, longer hospital stays, …

This study looks at how painkillers and sedatives are given to patients on ECMO, a life support machine for severe heart or lung failure. Researchers will collect data on current sedation use and work with patients, families, and staff to create a better sedation guide. The goal …

This study looks at how two common anesthesia drugs (propofol and alfentanil) change brain activity and pain signals during a procedure called ERCP. Researchers will record EEG (brain wave) data and pain monitor readings from 20 adults receiving general anesthesia. The goal is to…