Can tylenol and toradol replace opioids for ventilated kids?
NCT ID NCT06994442
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether giving acetaminophen (Tylenol) and ketorolac (Toradol) to children on ventilators can better control pain and reduce the need for strong opioids. About 644 children aged 2 months to 17 years with acute respiratory failure will be randomly assigned to receive one of four combinations of these drugs or a placebo. The goal is to see if these common pain relievers can improve comfort and safety.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Acetaminophen and ketorolac
- What this could lead to
- If it works, this could provide a safer, more effective way to manage pain in ventilated children, reducing their reliance on opioids.
- What could go wrong
- This is a Phase 3 trial, but results may not apply to all children. The medications may not significantly reduce pain or opioid use, and side effects like allergic reactions or bleeding are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Email: •••••@•••••
Locations
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Arkansas Children's Hospital
RECRUITINGLittle Rock, Arkansas, 72202, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Children's Hospital of Michigan
RECRUITINGDetroit, Michigan, 48201-2119, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Children's Hospital of Philadelphia
RECRUITINGPhiladelphia, Pennsylvania, 19104-4319, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Children's National Hospital
NOT_YET_RECRUITINGWashington D.C., District of Columbia, 20010-2916, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Duke Children's Hospital & Health Center
RECRUITINGDurham, North Carolina, 27705-4677, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Medical University of South Carolina
RECRUITINGCharleston, South Carolina, 29425, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Nationwide Children's Hospital
RECRUITINGColumbus, Ohio, 43205-2664, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Penn State Health/Hershey Medical Center
RECRUITINGHershey, Pennsylvania, 17033-0850, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Primary Children's Medical Center
RECRUITINGSalt Lake City, Utah, 84112-9023, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Rainbow Babies and Children's Hospital
RECRUITINGCleveland, Ohio, 44106-4919, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Texas Children's Hospital/Baylor College of Medicine
NOT_YET_RECRUITINGHouston, Texas, 77030-3411, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Michigan
NOT_YET_RECRUITINGAnn Arbor, Michigan, 48109-1274, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Minnesota
RECRUITINGMinneapolis, Minnesota, 55454-1450, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Pittsburgh
RECRUITINGPittsburgh, Pennsylvania, 15261-0001, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Wisconsin Children's
RECRUITINGMilwaukee, Wisconsin, 53226-3548, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Brain waves reveal hidden effects of breathing machines on injured brains
- Can High-Flow oxygen through a tracheostomy speed ventilator weaning?
- Mapping the waking brain: how ICU patients emerge from sedation
- Heart rate data may sharpen ICU nurses' decision-making
- Tweaking ventilator settings could ease breathlessness and cut PTSD risk in ICU survivors
- Hidden toll of routine ICU procedure revealed: suctioning may spike pain and stress