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Could less food help critically ill patients recover faster?

NCT ID NCT03573739

Disease control Sponsor: Nantes University Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 14, 2026 · Last updated Sep 15, 2026 · Updated 1 time

Summary

NUTRIREA-3 compares two feeding strategies for adults on ventilators with shock. One group receives low-calorie low-protein feeding for the first week, while the other receives standard-calorie standard-protein feeding. Researchers track survival and time to leave the ICU to see which approach works better.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
low-calorie low-protein feeding versus standard-calorie standard-protein feeding
What this could lead to
If low-calorie low-protein feeding works, it could change ICU feeding guidelines and help preserve muscle in critically ill patients, possibly shortening ventilation and hospital stays.
What could go wrong
This is a large trial, but critical illness is complex and results may not apply to all patients. Feeding too little could also cause malnutrition, so the balance is delicate.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

3,044 people

The number who actually took part.

Started

Jul 2018

Finished

Dec 2021

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Invasive mechanical ventilation started in the ICU within the past 24 h, or started before ICU admission with ICU admission within the past 24 h, for an expected duration of at least 48 hours after inclusion * Treatment with a vasoactive agent for shock (adrenaline, dobutamine, or noradrenaline) * Nutritional support expected to be started within 24 h after intubation or within 24 h after ICU admission when mechanical ventilation was started before ICU admission * Age older than 18 years * Patient and/or next-of-kin informed about the study and having consented to participation in the study. If the patient is unable to receive information and no next-of-kin can be contacted during screening for the study, trial inclusion will be completed as an emergency procedure by the ICU physician, in compliance with the French law. Exclusion Criteria: * Specific nutritional needs, such as pre-existing long-term home enteral or parenteral nutrition, for chronic bowel disease * Dying patient, not-to-be-resuscitated order, or other treatment limitation decision at ICU admission * Pregnancy, recent delivery, or lactation * Adult under guardianship * Department of corrections inmate

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Conditions

The condition(s) this trial relates to.

acute quadriplegic myopathy Critical Illness nosocomial infection Shock

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Critical illness Critical illness myopathy Mechanical ventilation Nosocomial infection Shock

Contacts and locations

Locations

  • C.H. de Rodez Hopital Jacques Puel

    Rodez, 12027, France

  • C.H.R. Pontchaillou

    Rennes, 35033, France

  • CH Emile Roux

    Le Puy-en-Velay, 43000, France

  • CH Pau

    Pau, 64000, France

  • CH Saint Brieuc

    Saint-Brieuc, 22000, France

  • CH Saint-Philibert

    Lomme, 59462, France

  • CH Valenciennes

    Valenciennes, 59300, France

  • CH de Bigorre

    Tarbes, 65013, France

  • CHU Angers

    Angers, 49100, France

  • CHU Cavale Blanche

    Brest, 29609, France

  • CHU DE TOURS Bretonneau

    Tours, 37044, France

  • CHU Nantes

    Nantes, 44093, France

  • CHU Paris Cochin

    Paris, 75014, France

  • CHU Pointe à Pitre - Abymes

    Pointe-à-Pitre, 97159, Guadeloupe

  • CHU de Saint Etienne

    Saint-Priest-en-Jarez, 42270, France

  • Centre Hospitalier Bretagne Atlantique - Vannes Auray

    Vannes, 56017, France

  • Centre Hospitalier D'Angouleme

    Angoulême, 16959, France

  • Centre Hospitalier D'Argenteuil

    Argenteuil, 95100, France

  • Centre Hospitalier Du Mans

    Le Mans, 72037, France

  • Centre Hospitalier Marc Jacquet

    Melun, 77011, France

  • Centre Hospitalier de Lens

    Lens, 62300, France

  • Centre Hospitalier de Montauban

    Montauban, 82013, France

  • Ch Annecy-Genevois

    Annecy, 74374, France

  • Ch Chartres Louis Pasteur

    Chartres, 28630, France

  • Ch Dieppe

    Dieppe, 76202, France

  • Ch General Delafontaine

    Saint-Denis, 93205, France

  • Chd Les Oudairies

    La Roche-sur-Yon, 85025, France

  • Chr - Hopital Roger Salengro

    Lille, 59037, France

  • Chr D'Orleans

    Orléans, 86709, France

  • Chu Amiens Picardie

    Amiens, 80054, France

  • Chu Bicetre

    Le Kremlin-Bicêtre, 94270, France

  • Chu Bocage

    Dijon, 21079, France

  • Chu Gabriel Montpied

    Clermont-Ferrand, 63003, France

  • Chu Jean Minjoz

    Besançon, 25030, France

  • Chu La Miletrie

    Poitiers, 86021, France

  • Chu de La Reunion Site Nord

    Saint-Denis, La Réunion, 97405, France

  • Chu de Nantes

    Nantes, 44000, France

  • Ctre Hosp Intercomm Andre Gregoire

    Montreuil, 93100, France

  • G.I.H. Bichat / Claude Bernard (Ap-Hp)

    Paris, 75877, France

  • Hopital Broussais

    St-Malo, 35403, France

  • Hopital Charles Nicolle Chu Rouen

    Rouen, 76038, France

  • Hopital Edouard Herriot

    Lyon, 69437, France

  • Hopital Europeen Georges Pompidou

    Paris, 75908, France

  • Hopital Foch

    Suresnes, 92150, France

  • Hopital Lariboisiere

    Paris, 75010, France

  • Hopital Louis Mourier (Ap-Hp)

    Colombes, 92701, France

  • Hopital Pellegrin Chu

    Bordeaux, 33000, France

  • Hopital Pitie Salpetriere

    Paris, 75013, France

  • Hopital Saint Antoine

    Paris, 75012, France

  • Hopital Saint Eloi

    Montpellier, 34295, France

  • Hopital de La Croix-Rousse

    Lyon, 69317, France

  • Hôpital Avicenne AP-HP

    Bobigny, 93000, France

  • Hôpital Michalon

    Grenoble, 38043, France

  • Hôpital Nord Franche Comté

    Belfort, 90015, France

  • Hôpital Raymond-Poincaré

    Garches, 92380, France

  • Hôpital Saint Louis (AP-HP)

    Paris, 75010, France

  • Hôpital de Béthune

    Béthune, 62408, France

  • Hôpital de Hautepierre CHU de Strasbourg

    Strasbourg, 67098, France

  • Hôpital du bois brulé

    Beauvais, 60000, France

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