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Gut bacteria and genes eyed as keys to predicting repeat c. diff

NCT ID NCT04801862

Diagnosis Sponsor: Hospital Universitario de Valme Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 17, 2026 · Last updated Sep 18, 2026 · Updated 1 time

Summary

Researchers are studying adults with Clostridioides difficile infection to learn why some people get a repeat infection. The trial follows 750 patients across multiple hospitals, collecting blood for genetic testing and stool samples to examine gut bacteria. The goal is to build a tool that uses clinical, genetic, and microbiological factors to predict who is most likely to have C. diff return.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If the tool works, doctors could flag patients at high risk of a repeat C. diff infection and watch them more closely. That may mean faster treatment and fewer hospital readmissions.
What could go wrong
The study observes patients rather than testing a treatment, so it cannot prove that any single factor causes recurrence. A prediction tool built from these data may not work as well in other hospitals or patient groups.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 750 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2021

Expected to finish

Dec 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adult patients diagnosed of Clostridoides difficile infection

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age older than 18 years * New episode of Clostridioides difficile infection, based on IDSA criteria. Exclusion Criteria: \- None

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Conditions

The condition(s) this trial relates to.

Clostridium difficile colitis Clostridium infectious disease nosocomial infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Clostridium difficile infection Health care associated infection Nosocomial infection

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    12 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Consorcio Hospital General de Valencia

    RECRUITING

    Valencia, Valencia, Spain

  • Hospital Clínico Universitario de Valencia

    RECRUITING

    Valencia, Valencia, Spain

  • Hospital General Universitario de Alicante

    RECRUITING

    Alicante, Spain

  • Hospital Juan Ramón Jiménez

    RECRUITING

    Huelva, Huelva, Spain

  • Hospital Marina Baixa

    RECRUITING

    Villajoyosa, Alicante, Spain

  • Hospital Politécnico Universitario La Fe de Valencia

    RECRUITING

    Valencia, Valencia, Spain

  • Hospital Regional Universitario de Málaga

    WITHDRAWN

    Málaga, Málaga, Spain

  • Hospital Universitario Reina Sofía

    TERMINATED

    Córdoba, Spain

  • Hospital Universitario San Cecilio

    RECRUITING

    Granada, Granada, Spain

  • Hospital Universitario San Juan

    RECRUITING

    Alicante, Alicante, Spain

  • Hospital Universitario Virgen Macarena

    RECRUITING

    Seville, Spain

  • Hospital Universitario Virgen de la Victoria

    RECRUITING

    Málaga, Málaga, Spain

  • Hospital Universitario de Puerto Real

    TERMINATED

    Puerto Real, Cadiz, Spain

  • Hospital Universitario de Valme

    RECRUITING

    Seville, Spain

  • Hospital Vega Baja

    RECRUITING

    Orihuela, Alicante, Spain

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