Acute quadriplegic myopathy
MONDO:0004969Acute quadriplegic myopathy (AQM) is a specific acquired myopathy in ICU patients. Patients with AQM are characterized by severe muscle weakness and atrophy of spinal nerve innervated limb and trunk muscles, while cranial nerve innervated craniofacial muscles, sensory and cognitive functions are spared or less affected. The muscle weakness is associated with altered muscle membrane properties and a preferential loss of the motor protein myosin and myosin-associated thick filament proteins. Prolonged mechanical ventilation, muscle unloading, postsynaptic block of neuromuscular transmission, sepsis and systemic corticosteroid hormone treatment have been suggested as important triggering factors in AQM.
15 clinical trials for this condition and its sub-types.
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Home rehab program aims to keep heart patients out of hospital
Disease control Recruiting nowThis study tests whether a 4-month structured telerehabilitation program, delivered via video calls and an app, can reduce deaths and hospital readmissions in heart patients who have Post-Intensive Care Syndrome (PICS). About 326 adults aged 30-75 who were in the ICU for at least…
Sponsor: Fondazione Don Carlo Gnocchi Onlus • Aim: Disease control
Last updated Jun 27, 2026 13:03 UTC
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New handheld scanner could replace MRI for muscle disease monitoring
Diagnosis Recruiting nowThis study is testing a handheld device called mScan that uses a tiny, painless electrical current to measure muscle health. Researchers want to see if it can give similar results to an MRI, but faster and more conveniently. The study involves 150 adults with and without muscle d…
Sponsor: Beth Israel Deaconess Medical Center • Aim: Diagnosis
Last updated Jun 27, 2026 12:03 UTC
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Robots and VR join the fight to recover from nerve and muscle diseases
Symptom relief Recruiting nowThis study compares a high-tech rehabilitation program—using robotic systems, virtual reality, and balance platforms—to standard physical therapy for people with acute neuromuscular diseases like Guillain-Barré syndrome. About 124 adults aged 18 to 80 will participate. The goal i…
Sponsor: Istituti Clinici Scientifici Maugeri SpA • Aim: Symptom relief
Last updated Jun 27, 2026 09:09 UTC
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Bed cycling may stop muscle wasting in critically ill patients
Knowledge-focused Recruiting nowThis study tests whether adding servo-assisted bed cycling to standard physical therapy can reduce muscle breakdown in critically ill patients with sepsis. Researchers will measure inflammation and muscle damage markers in 24 participants over 7 days. The goal is to understand if…
Sponsor: University of Chile • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:29 UTC
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Hidden weakness: study reveals nerve and muscle damage in Non-ICU patients
Knowledge-focused Recruiting nowThis study investigates whether serious muscle weakness, known to affect ICU patients, also occurs in people hospitalized outside the ICU. Researchers will follow about 600 adults in Italian hospitals, half with organ failure and half without, to see how often weakness develops a…
Sponsor: Istituto Clinico Humanitas • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:02 UTC
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Tiny study aims to unlock mystery of ICU muscle wasting
Knowledge-focused Recruiting nowThis pilot study is looking at why some patients in the intensive care unit (ICU) develop severe muscle weakness after surgery. Researchers will take blood and small muscle samples from 20 high-risk patients to look for chemical changes that might cause or signal this weakness. T…
Sponsor: Technical University of Munich • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:09 UTC
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Ventilator Patients' diaphragm decline measured in new study
Knowledge-focused Recruiting nowThis study tracks how quickly the diaphragm weakens in 15 ICU patients on mechanical ventilation. Researchers use advanced muscle tests and brain stimulation to measure changes in diaphragm function and control. The goal is to better understand ventilator-induced diaphragm dysfun…
Sponsor: RWTH Aachen University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:04 UTC
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Wearable tech tracks fatigue in muscle disease patients
Knowledge-focused Recruiting nowThis study aims to find better ways to measure fatigue and walking problems in people with neuromuscular diseases like muscular dystrophy and spinal muscular atrophy. Researchers will use a wearable sensor to track physical activity for one week in daily life and during a walking…
Sponsor: IRCCS Eugenio Medea • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:12 UTC
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New study aims to uncover why some ICU patients struggle to regain strength
Knowledge-focused Recruiting nowThis study follows 100 adults who needed ECMO support for severe heart or lung failure. Researchers will track muscle size, strength, and quality of life over time to understand why some patients develop lasting weakness. No new treatments are being tested; the goal is to gather …
Sponsor: Barts & The London NHS Trust • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:08 UTC