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Acute quadriplegic myopathy
MONDO:0004969Acute quadriplegic myopathy (AQM) is a specific acquired myopathy in ICU patients. Patients with AQM are characterized by severe muscle weakness and atrophy of spinal nerve innervated limb and trunk muscles, while cranial nerve innervated craniofacial muscles, sensory and cognitive functions are spared or less affected. The muscle weakness is associated with altered muscle membrane properties and a preferential loss of the motor protein myosin and myosin-associated thick filament proteins. Prolonged mechanical ventilation, muscle unloading, postsynaptic block of neuromuscular transmission, sepsis and systemic corticosteroid hormone treatment have been suggested as important triggering factors in AQM.
15 clinical trials for this condition and its sub-types.
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New study aims to perfect how we measure muscle recovery in ICU survivors
Knowledge-focused OngoingThis study looks at whether a tool called the Chelsea Critical Care Physical Assessment tool (CPAx) can accurately track recovery in 120 adults who developed muscle weakness after being on a breathing machine in the ICU. The goal is to find the smallest meaningful improvement tha…
Sponsor: Insel Gruppe AG, University Hospital Bern • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:37 UTC
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ICU muscle mystery: new study aims to uncover why patients stay weak
Knowledge-focused OngoingThis study looks at why over half of ICU patients develop severe muscle weakness that can last for months or years. Researchers will use muscle biopsies, ultrasound, and strength tests on 50 critically ill adults to find better ways to diagnose and track this condition. The goal …
Sponsor: Vanderbilt University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:01 UTC
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Hidden muscle wasting in ICU: new study to reveal true toll
Knowledge-focused By invitation onlyThis study looks at how often muscle loss (sarcopenia) happens in adults who need a breathing machine in the ICU for more than 48 hours. Researchers will measure muscle health using simple tests and ultrasound. The goal is to understand how common this problem is and how it chang…
Sponsor: Hospital Mutua de Terrassa • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:06 UTC