SHOCK

This study tests whether a digital platform that monitors blood pressure and symptoms at home can improve outcomes for people with early cardiogenic shock, a serious heart condition. About 472 patients will be split into two groups: one gets standard discharge care, the other get…

This study tests four different drugs (norepinephrine, epinephrine, phenylephrine, and vasopressin) in ICU patients with shock that doesn't improve with fluids. The goal is to see which drug causes fewer dangerous heart rhythm problems and improves survival. About 836 adults will…

This study tests whether giving fluids and blood pressure medicines based on each patient's heart response can improve sepsis care. 188 adults with sepsis in the emergency department will be randomly assigned to either personalized treatment or standard care. The goal is to see i…

This study tests a new way to see if patients in shock need intravenous fluids. Doctors will use a heart ultrasound measurement (E') before and after giving fluids to see if it can predict who will respond. The goal is to make fluid decisions faster and more accurate in the emerg…

This study tests whether the Argos system, a non-invasive monitor, can reliably measure changes in cardiac output (how much blood the heart pumps) in critically ill patients with shock. Researchers will compare its readings to those from a standard invasive device during fluid in…

This study looks at why some people who survive a serious illness in the ICU develop long-lasting muscle weakness. Researchers will test 50 former ICU patients with exercise on a bike to measure heart and muscle function. The goal is to better understand this condition, not to te…

This observational study looks at how the right side of the heart adapts when critically ill patients receive fluids. Researchers will use ultrasound to measure heart function before and after fluid administration in 100 adults. The goal is to understand why some patients develop…

This study looks at whether doctors can rely on feeling a patient's pulse (in the neck, groin, or wrist) to know if their blood pressure is dangerously low during shock. Researchers will compare pulse checks with standard blood pressure readings in 5,000 critically ill adults in …

This study looks at 100 ICU patients with shock who are on a breathing machine. Doctors will use an ultrasound to measure the size of a vein and artery in the leg. They want to see if this ratio can tell whether giving fluids will help the heart pump more blood. The goal is to fi…

This study aims to find out how often a blood pressure difference between the arm and leg occurs in patients with shock. Researchers will measure blood pressure non-invasively in 180 adults receiving strong vasopressors. The goal is to understand this gap better, so doctors can a…

This study looks at whether raising blood pressure to a higher target (80-85 mmHg) improves kidney function in adults with shock and high central venous pressure. About 30 participants will be monitored. The goal is to learn if personalized blood pressure targets can protect the …

This study looks at tiny particles called extracellular vesicles in the umbilical cord blood of extremely premature babies (born before 28 weeks). Researchers want to see if these particles can help predict serious problems like brain bleeding, lung injury, or death. The goal is …

This study looks at whether using a special heart ultrasound (called TEE) during emergencies helps doctors make better decisions and improves patient outcomes. Researchers will track 1,000 critically ill adults in the ER or ICU who receive this test as part of their care. The goa…

This study compares two techniques for inserting a central venous catheter in adult emergency department patients with shock. Researchers want to see which method leads to higher first-attempt success, fewer complications, and faster completion. 160 participants will be randomly …

This study is looking at whether a protein called vasorin (Vasn) in the blood can help doctors quickly tell the difference between septic shock (caused by infection) and other types of shock (like after heart surgery). Currently, the best test for this is not always accurate. The…