SHOCK

This study tests whether two drugs, phenylephrine and vasopressin, can lower the risk of dangerous heart rhythm problems in ICU patients with shock compared to standard drugs norepinephrine and epinephrine. About 836 adults with shock not improving after fluids will be randomly a…

This study tests whether giving fluids and blood-pressure medicine based on each person's heart response can improve care for sepsis patients in the emergency department. Sepsis is a life-threatening reaction to infection that can cause organ failure. The study will compare a per…

This study looks at whether a simple heart ultrasound measurement (called E' variation) can tell doctors if a patient in shock will benefit from intravenous fluids. Researchers will measure the E' wave before and after giving 500 mL of fluid to 187 emergency department patients. …

This study looks at whether a protein called vasorin can help doctors quickly tell the difference between septic shock (caused by infection) and other types of shock (like after heart surgery). Researchers will measure vasorin levels in 144 intensive care patients and compare the…

This study looks at whether using a special heart ultrasound (called transesophageal echocardiography) during emergencies helps doctors better treat critically ill patients, including those in cardiac arrest or shock. Researchers will track 1,000 adults in the ER and ICU to see i…

This study looks at why many people who survive a serious illness in the ICU develop lasting muscle weakness. Researchers will test the heart and blood flow of 50 former ICU patients during exercise. The goal is to better understand the problem, not to test a new treatment.

This study compares two techniques for placing a central venous catheter (a large IV) in emergency department patients with shock. Researchers want to see which method leads to more successful first attempts, fewer complications, and faster completion. About 160 adults who need a…

This study looks at whether increasing blood pressure can improve kidney function in people with shock who also have high pressure in a major vein near the heart. About 30 adults on strong blood-pressure medication will be monitored. Researchers will measure kidney function at tw…

This study looks at tiny particles called extracellular vesicles in the umbilical cord blood of babies born before 28 weeks. Researchers want to see if these particles can help predict serious problems like brain bleeding, lung injury, or death. The goal is to find early warning …

This study looks at whether measuring the size of the femoral vein compared to the femoral artery in the leg using ultrasound can help doctors decide if a critically ill patient in the ICU needs more fluids. It involves 100 adults on breathing machines who already have special mo…

This study looks at how often there is a meaningful difference in blood pressure measured at the arm (radial artery) versus the leg (femoral artery) in people with shock. About 180 adults on strong blood-pressure-raising medicines will be checked. The goal is to learn how common …

This study looks at two different methods to measure how much blood the heart pumps in people with shock. One method uses ultrasound (echocardiography), and the other uses a special monitor that tracks blood flow through the skin (bioreactance). The goal is to see how well these …